Austin Battersea Stehelin, a Swiss professor at the School of Life Sciences, Sun Yat-sen University, and Xie Zhiping, an associate professor at the School of Life Sciences, Sun Yat-sen University, Yangcheng Evening News reporter Huang Yijun.　

Austin Battersea Stehelin was awarded the 2019 China Government Friendship Award (photo courtesy of the respondent).

　　On the afternoon of September 30th, the awarding ceremony of 2019 China Government Friendship Award was held in the Great Hall of the People. According to the news released by the Science and Technology Department of Guangdong Province, a total of seven foreign high-end experts were selected in Guangdong this time, and the number of selected experts was the highest in the past years. Among the seven experts, there is Christian Balthasar Staehelin, a full-time professor of Sun Yat-sen University, an academic leader of the State Key Laboratory of Pest Control and Resource Utilization, who is committed to studying plant genetic resources and genetic improvement.

　　Fourteen years ago, the Swiss Austin Battersea Stehelin and his wife Xie Zhiping from China traveled across the ocean to the School of Life Sciences of Sun Yat-sen University, bringing the international cutting-edge biological nitrogen fixation technology.

　　They provided more than 100 valuable rhizobia germplasm resources to China free of charge, uncovered the "language code" between these microorganisms and leguminous plants, created a "vanguard" of microorganisms and leguminous plants for soil remediation, and used green methods to make polluted mines return to green mountains.

　　Recently, the reporter interviewed the couple exclusively and listened to their stories about Professor Yang’s feelings in China.

　　A

　　Bring cutting-edge technology and valuable strains.

　　Nitrogen is one of the essential nutrients for plant growth. There is nearly 80% nitrogen in the atmosphere on the earth’s surface, but plants can’t absorb it directly from the air. At present, industrial chemical fertilizer is the most common nitrogen fixation method. However, only one-third of the nitrogen in chemical fertilizer can be absorbed by plants, and the remaining two-thirds remain in nature, causing problems such as soil hardening, water pollution, eutrophication of water bodies and increase of greenhouse gases.

　　Is there a more environmentally friendly way to make plants thrive? Austin Battersea Stehelin spent 30 years studying a group of microorganisms called rhizobia.

　　In China, this Swiss professor has a kind name — — "Old history". Walking into the plant room of the laboratory and picking up a Japanese lotus root, Lao Shi excitedly pointed to the tumors the size of rice grains between the plant roots in the culture solution and said, "Look, this is the nodule."

　　The mystery of plant growth lies in these small "rice grains".

　　When the right rhizobia meet the right plants, they can "talk" and coexist — — Rhizobia absorb nitrogen from the air and provide it to plants, and plants provide carbohydrates for rhizobia.

　　Once their "language code" is cracked, Lao Shi can accurately select rhizobia according to the needs of different plants and fix the nitrogen in the air on the roots of plants. Almost all of the nitrogen fixed by nodules will be absorbed by plants. In this way, no matter how harsh the environment is, as long as there is air, plants can thrive. This is the secret of biological nitrogen fixation.

　　It is not easy to find the right rhizobia. Lao Shi told reporters that in the current research, rhizobia can only interact with leguminous plants, and the bacteria that can successfully form nodules are even rarer. In China, this research is still very unpopular because of the high technical threshold and difficult strain screening.

　　In 2005, the old Shi Xuan and his wife Xie Zhiping, who are well-known in the international biological nitrogen fixation academic circles, both came to China to teach at Sun Yat-sen University. At the same time, he put his years of research efforts — — More than 100 rhizobia germplasm resources and effective technology for extracting nodulation factors were provided to China free of charge.

　　The broad-spectrum rhizobia 234 brought by him has been used as the "standard/control" bacteria for scientific research by many domestic research institutions, and the nodulation factor extracted has also been used as the "key" scientific research element for many scientific research institutions. He brought the latest scientific research ideas to China, which opened up a new prospect of nitrogen-fixing scientific research in China, and was recommended as the project leader of the National Key Basic Research Development Plan (973 Plan) (Molecular Mechanism of Nitrogen-fixing Nodules in Leguminosae Plants).

　　B

　　Couples work together to study soil pollution remediation.

　　Basic research is very boring. This bench has been used by Lao Shi for 30 years, and nearly half of the time has been spent in China.

　　"He likes doing scientific research and can sit still in the laboratory." Xie Zhiping, the wife of Lao Shi and an associate professor at the School of Life Sciences of Sun Yat-sen University, laughed.

　　The love story between Lao Shi and Xie Zhiping is romantic in the ordinary. Xie Zhiping is a native of Guangzhou. She studied in Guangdong Experimental Middle School in middle school and graduated from Sun Yat-sen University. She studied for a master’s degree and a doctor’s degree in university of basel, the oldest Swiss city, and got to know the old history. After graduating from Ph.D., Lao Shi went to the French National Academy of Sciences for postdoctoral research, and then returned to work at the University of Geneva.

　　In a foreign country, Xie Zhi often misses his hometown. She proposed that she wanted to return to China and her alma mater, Sun Yat-sen University. "Guangzhou is your home, that is my home, let’s go together!" Lao Shi said.

　　In 2005, "Professor Yang" really came. Xie Zhiping told reporters that at that time, there were very few western scientists introduced in China, and Lao Shi was the first full-time foreign professor introduced by Sun Yat-sen University.

　　Fourteen years ago, domestic scientific research conditions could not be compared with those in Europe at that time. At that time, Guangzhou University Town had just been completed, and the hot summer in Lingnan made it difficult for the old history who grew up in Europe to adapt. Air conditioning became his "life-saving straw".

　　Back in the lab, everything started from scratch. Mr. and Mrs. Lao Shi took the students to design their own molds for cultivating plants and build greenhouses.

　　"Before coming to China, many people told me that China was too far away. But in my research world, China’s laboratory is no different from foreign laboratories. " Lao Shi told reporters. With the support of Sun Yat-sen University, the laboratory gradually took shape, and an interdisciplinary research team including botany, microbiology, biochemistry and molecular biology was established. Lao Shi also instructed team members to publish more than 50 high-level papers in international academic journals.

　　"We like nature very much and hope to do something when we see that the environment is polluted." Lao Shi said.

　　To this end, the couple often take their students to collect soil samples in the wild, and go wherever they are "dirty". The reporter saw that there were polluted river sludge, extremely acidic polluted mineral soil, extremely salty sea sand and barren desert soil in the laboratory. They used these soils, added rhizobia, planted all kinds of leguminous plants, and explored the interaction between rhizobia and rice, corn and other crops to meet the needs of various soils and even sewage treatment.

　　C

　　Willing to contribute to environmental protection in China.

　　According to Lao Shi, every tiny nodule is a natural "garbage disposal plant" and "microbial hospital". Some rhizobia can absorb heavy metals in polluted soil; Some can fix nitrogen in nutrient-free soil to promote plant growth.

　　Three years ago, with the full support of Sun Yat-sen University and Kangtai Minsheng Environmental Science Research Institute, Lao Shi and his wife chose a 30-mu abandoned rare earth mining area in Ganzhou, Jiangxi Province to carry out soil remediation experiments. It was a devastated piece of rare earth tailings. Rare earth mining seriously damaged the original ecology of the mine, resulting in soil erosion, serious pollution of downstream rivers and lakes and groundwater, and deterioration of the ecological environment. The strong acid soaking in the process of rare earth mining almost made this land lose its vitality — — The soil desertification is serious and extremely barren, the ability of water and fertilizer conservation is poor, the organic matter and other soil essential elements are lacking, and the soil microbial diversity is seriously damaged.

　　"Almost no plants can grow in such bad soil." This is the first impression left by the field trip to the couple.

　　The local people tried to repair it. They used the most primitive "alien soil method". They transported good soil from other places to cover the polluted soil with a thickness of about 30 cm, and then planted plants. This method treats the symptoms rather than the root cause. After the restoration, the first batch of plants are planted and die soon, and then they are planted again, and so on. The cost of repairing an acre of land alone will cost tens of thousands of yuan.

　　Mr. and Mrs. Lao Shi did an experiment with biological nitrogen fixation: Stylosanthes leguminosa was planted here as a "pioneer" and supplemented with corresponding rhizobia to "cure the disease" for this soil. What is the actual effect? Three years later, Lao Shi went to see it again. Not only did Stylosanthes grow lush, but the pine trees originally planted here also survived, growing four or five meters high. "With the joint action of rhizobia and nitrogen-fixing plants, this soil has returned to health and other plants can grow well."

　　Now, Lao Shi and his team have chosen a new pilot and brought this "vanguard" to Dabaoshan Mine in Shaoguan, Guangdong Province, to pilot soil remediation. Xie Zhiping told reporters that they are still trying to purify sewage with rhizobia and leguminous plants in the laboratory. "Sewage is actually eutrophic. Leguminous plants with rhizobia can absorb nutrients and toxic molecules in sewage. Once the plants are pulled out, the water will be clearer."

　　Scientists have no borders, and scientific research never stops. Living in China for 14 years has turned Lao Shi from a foreigner who is afraid of heat into a "Guangzhou son-in-law" who can speak a few Cantonese. More and more, he found that his research is very useful for China, especially for environmental governance.

　　"The ultimate goal of scientific research is to serve the society." Lao Shi often warns students, "Do scientific research well, you can’t waste taxpayers’ money, you must give back to the society."

　　"We don’t want to just put knowledge in the laboratory. We have the responsibility and obligation to make some contributions to China and human society." He said.

　　After winning the Friendship Award this time, Lao Shi said: "It is a great honor to be awarded the Friendship Award of the China Municipal Government. I will continue to make efforts to contribute to the green mountains and green hills of China." (Yangcheng Evening News reporter Zhang Luyao)

　　Emotional kidnapping, service congestion, scheming and indulging … … In the daily scene of compulsory attention to WeChat official account after scanning the QR code, there is a logic that "you can’t XX without paying attention".

　　Pink-up has formed an industrial chain. On a variety of pink-up platforms, some weighing scale fans only need 7 cents each, and 3,000 pieces will be sold, with large quantities and discounts.

　　Compulsory attention to WeChat official account to earn traffic is only the first step, and other profitable behaviors such as taking personal information and accurately pushing advertisements will follow.

　　"Are you there? Vote for me?" Click on the link sent by relatives and friends, but I want to enter the voting channel only to find that I should pay attention to WeChat official account first; When I came to the door of the pharmacy, a small line appeared on the weighing scale, which was intended to help customers understand the basic health conditions such as height and weight: "Scan the QR code and you can use it"; I plan to drive away from the garage after shopping, but I don’t care that WeChat official account can’t continue to pay the fee … … In the scanning code again and again in daily life scenes, the list of "subscription numbers" of mobile phones becomes longer and longer.

　　Pay, add friends and get information … … With the rapid development of Internet and mobile payment, the operation of "scanning QR code" is becoming more and more popular, which brings a lot of convenience to people. However, at the moment of chasing users’ attention, it is not uncommon to force attention to WeChat official account after scanning the QR code. Stranger still, the WeChat official account may have nothing to do with the user’s ongoing activities.

　　Why can’t we "bypass" WeChat official account? The reporter’s investigation found that there is a hidden gold chain behind it.

　　Hit Xu Juntu/this magazine

　　Do everything possible just to attract attention

　　Use WIFI in public places, and use coupons for hotel bills … … There is a logic that "you can’t do XX without paying attention" in many scenes of compulsory attention to WeChat official account. The reporter combed and found that the reasons for pushing people to submit can be subdivided into three categories:

　　Emotional "kidnapping" type WeChat official account used the interpersonal network of the direct participants to "escort" with feelings, and distributed the task of paying attention to WeChat official account as an adjunct to voting and helping others.

　　White-collar Ling Lu inadvertently cleaned up WeChat and found that less than half of the "subscription numbers" were what he really wanted to pay attention to. "The most common situation is voting. You must first pay attention to WeChat official account, the sponsor of the voting." Ling Lu said that due to family ties and friendship, I can’t help but vote. Sometimes I forget to cancel my attention after voting, and I have saved so much unconsciously.

　　Service "jam" type. The public company cooperates with the merchants to take "paying attention to the public company" as a compulsory channel for users to complete services and attract traffic.

　　When Cheng Xiaoqi, a citizen of Nanchang, Jiangxi, recently parked in the underground garage of a large shopping mall, he was asked to pay attention to a WeChat official account named "Stop on time" with WeChat. When asked whether direct payment could be made without paying attention to WeChat official account, the staff said no. Cheng Xiaoqi questioned: "What can be solved by scanning a receipt code? Why do I have to pay attention to WeChat official account?"

　　Click "Stop on time", and the main body of this account is Jiangxi Yixing Intelligent Parking Management Co., Ltd. The reporter called the company’s customer service, and the other party said that the cooperation between WeChat official account and the parking lot would require the parking lot to guide users to pay fees through the platform, which was a business model, and he was concerned that WeChat official account "would not bring any losses to car owners". When the reporter further confirmed that "I don’t care if I can’t pay for leaving", the customer service first said that there is another QR code that can pay directly. After the reporter said that he didn’t see the QR code in the relevant parking lot, the customer service also called "it depends on the parking lot".

　　The "inducement" type. The public party, that is, the service provider, defaults to the platform as the "necessary carrier" for using services and offers to guide attention, which is more concealed.

　　Nowadays, when you go to a restaurant to spend money, some restaurants no longer provide paper menus. The waiter will remind customers to order through the QR code posted on the corner of the table. And many ordering QR codes ambush a "careful machine": only when you pay attention to the WeChat WeChat official account of the store can you order food; Linking attention to WeChat official account with preferential activities has become one of the means for most "no paper menu" hotels to retain guests.

　　"weighing scale fans" are 70 cents each.

　　In the Internet age, fans mean value. It is WeChat official account’s desire to "suck gold" after rising in powder, which triggered a series of operations to pay compulsory attention to WeChat official account.

　　Mr. Zhang is the head of an operation in WeChat official account, where a single tweet has been read more than 100,000 times. He revealed to reporters that the current cost of acquiring a fan through official channels is around 5 yuan to 10 yuan. Because of the high cost of obtaining customers, only WeChat official account, a capital-rich head, can afford it, and most WeChat official account can only choose unofficial channels to raise money at the initial stage.

　　Search for "WeChat official account Pink" in Baidu, and a variety of pink platforms will come into view. Industry insiders told reporters that at present, Fanfen has formed an industrial chain. The accuracy of fans, the richness of equipment channels and the professionalism of customized solutions have become the main means for platforms to compete for customers’ competitiveness, and compulsory attention has become the main means for platform offline customers.

　　The reporter investigated a powder-increasing platform that mainly helps customers realize their demand for powder-increasing through offline equipment, and found that there are many offline scenes promoted on its corporate homepage, including weighing scale, doll machine, shared charging treasure, vending machine, hospital equipment powder-increasing, karaoke powder-increasing, WIFI powder-increasing, etc. There are also differences in retention rate, age group and price among different channels.

　　For example, if the hospital equipment is powdered, users can pay attention to WeChat official account to receive environmental protection bags or medical records for free by scanning the code in the hospital. The retention rate of fans in this scene is 60% to 80% of that day, and the age group is 18 to 45 years old; The doll machine adds powder by inducing users to scan the code to pay attention to WeChat official account’s voucher collection. The retention rate of fans is 60% to 80%, and the age group is 18 to 35 years old.

　　"This company is well-known in the industry and has offline equipment all over the country. Because the equipment is laid directly offline, the customer’s cost of obtaining customers is relatively low. The cheapest weighing scale fans only need 7 cents each, and 3,000 are sold, with a large quantity and a discount. " Sales staff said that many so-called powder-increasing platforms on the Internet actually don’t have the ability to get customers offline, and most of them cooperate with first-hand customer-obtaining platforms like them to earn the middle price difference by being a "profiteer".

　　Another powder-raising platform has only three ways of powder-raising: paper towel machine, weighing scale and WIFI. The price of powder-raising package in weighing scale is: 1,000 fans 900 yuan, 4,000 yuan for 5,000 fans and 7,000 yuan for 10,000 fans. The prominent position of its homepage is also straightforward, indicating that the number of customers served has exceeded 25,000, with a cumulative increase of 90 million, and the amount of powder increased by more than 120,000 that day.

　　Seemingly voluntary, but actually compulsory.

　　Is there any infringement in WeChat official account’s behavior when he is forced to pay attention to "no consultation"? According to the experts interviewed, under the premise of consumption, it is a kind of "voluntary in form and compulsory in essence" for merchants to force consumers to pay attention to WeChat official account.

　　"You must scan the code to pay attention to WeChat official account to order food, which is suspected of infringing on consumers’ right to choose independently." Gu Zhiming, Secretary-General of Jiangxi Consumer Protection Committee, said that Article 26 of the Consumer Protection Law stipulates that operators shall not exclude or restrict consumers’ rights, reduce or exempt operators’ responsibilities, increase consumers’ responsibilities and other unfair and unreasonable provisions to consumers by means of format clauses, notices, statements and shop notices, and shall not use format clauses and technical means to force transactions. Format clauses, notices, statements, shop notices, etc. contain the contents listed in the preceding paragraph, and their contents are invalid.

　　What’s more, according to industry insiders, the ultimate goal of business promotion is to turn online traffic into offline revenue. It is only the first step to pay compulsory attention to WeChat official account to earn user traffic, and other profitable behaviors such as obtaining personal information and accurately pushing advertisements will follow.

　　Zeng Yue, a lawyer of Jiangxi Qiuzheng Ward Law Firm, said that when WeChat users pay attention to WeChat official account, they will often receive a prompt that "WeChat official account has applied for your WeChat avatar, nickname, region and gender information". If they don’t click "allow", they will not be able to pay attention and get the services provided by WeChat official account. There is also the risk of revealing personal information for WeChat users, especially the elderly who are not very likely to use mobile phones to surf the Internet.

　　"The original intention of QR code is to make life more convenient, but it is mandatory to pay attention to what WeChat official account can consume ‘ Additional terms ’ To a certain extent, it also excludes the consumption rights of non-netizen groups. " Ruan Xinyi, a lawyer of Shanghai Jintiancheng (Nanchang) Law Firm, said that in the context of Internet consumption becoming a general trend, it is the only way to win the support of consumers to advocate businesses to simplify operating procedures while providing high-quality Internet products or services, to exercise their rights to the minimum extent and to protect the rights of network users to the maximum extent. (Reporter Hu Jinwu, Yuan Huijing)

Original Jiulu Medical Digestive Liver Disease Channel was included in the collection # World Hepatitis Day 4 # Hepatitis B 3 # Hepatitis B Vaccine 1.

For medical professionals’ reference only.

Actively vaccinate against hepatitis B and eliminate hepatitis B at an early date.

China is a country with high prevalence of hepatitis B infection. It is estimated that there are about 70 million people infected with chronic hepatitis B virus (HBV), including 20-30 million patients with chronic hepatitis B.

Since hepatitis B was included in the planned immunization management in China in 2002, the survey in 2014 showed that the number of hepatitis B carriers among children under 5 years old dropped to 0.32%, which means that more than 80 million children have been protected from hepatitis B infection since the implementation of hepatitis B vaccine. So who needs hepatitis B vaccine? How long does the protection last? Do you want to replant?

On July 28th, World Hepatitis Day, the "medical community" invited Professor Jiang Yongfang, member of the Infectious Diseases Branch of the Chinese Medical Association and director of the Infectious Diseases Department of the Second Xiangya Hospital of Central South University, to make a detailed interpretation of hepatitis B vaccination according to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2019) (hereinafter referred to as the "Guidelines").

Hepatitis B vaccine is the most effective way to prevent HBV infection.

"Hepatitis B vaccine mainly reduces or avoids hepatitis B infection by producing effective hepatitis B surface antibodies after inoculation. However, with the extension of time, the protection of hepatitis B surface antibodies will also decrease. " Director Jiang introduced.

Different people are vaccinated with hepatitis B vaccine, and the precautions are different. For high-risk groups, such as medical personnel, people engaged in food processing, and people whose immediate family members are infected with hepatitis B, they should be vaccinated with hepatitis B vaccine and tested for hepatitis B surface antibodies for 3-5 years. Director Jiang said: "For patients whose titer of hepatitis B surface antibody is less than 100, they should be strengthened or re-vaccinated with hepatitis B vaccine."

For ordinary people who are vaccinated with hepatitis B vaccine, they should also be tested for hepatitis B surface antibody for 5-10 years. If the hepatitis B surface antibody decreases, they should also be strengthened or re-vaccinated with hepatitis B vaccine.

Director Jiang also mentioned, "In recent years, great changes have taken place in hepatitis B vaccine in China, from inactivated/attenuated vaccine in 1970s to gene recombination vaccines now. Compared with inactivated/attenuated vaccine, the side effects of gene recombination vaccines are relatively few, and for most people, hepatitis B vaccine has no absolute contraindication. However, patients who are allergic to vaccines during the period of cold and fever should choose not to be vaccinated with hepatitis B vaccine.

"China has a large population base and a large number of hepatitis B vaccinations. We are very experienced in the quality and efficiency of hepatitis B vaccination and have strong safety. In general, hepatitis B vaccine is a key measure to reduce hepatitis B infection. " Director Jiang stressed.

Hepatitis B vaccination targets are mainly newborns.

The sooner you get the hepatitis B vaccine, the better. The guideline suggests that the target of hepatitis B vaccination is mainly newborns, followed by infants, uninmunized people under the age of 15 and high-risk people. Hepatitis B vaccine needs to be inoculated with 3 shots in the whole process, that is, according to the procedures of 0, 1 and 6 months, after the first shot, the second and third shots are inoculated at 1 month and 6 months.

The guideline also added the first dose of hepatitis B vaccine and hepatitis B immunoglobulin as soon as possible within 12 hours of birth for premature infants and low-birth-weight infants born to mothers with unknown HBsAg. After one month of age, complete hepatitis B vaccine immunization according to the procedures of 0, 1 and 6 months.

Director Jiang emphasized: "The purpose of this is to reduce the infection risk of premature infants and low-energy infants when the mother’s infection is unknown."

Improve the success rate of mother-to-child blocking

Hepatitis B is mainly transmitted through mother-to-child, blood and sex. Before the implementation of neonatal hepatitis B vaccine immunization program in China, HBV was mainly transmitted from mother to child. Newborns with HBsAg positive mothers should be vaccinated with hepatitis B vaccine and hepatitis B immunoglobulin within 12 hours of birth for mother-to-child blocking. At present, the success rate of mother-to-child blocking has reached more than 95%, but 5% of children still fail to block mother-to-child.

Director Jiang explained: "The failure of mother-to-child blocking is mainly related to the following three points. First: the mother’s hepatitis B virus load is very high; Second, the mother is positive for HBsAg and E antigen; Third: the vaccination is not standardized, parents do not pay attention to it, and the second and third doses of hepatitis B vaccine are not vaccinated in time. "

For newborns who have failed mother-to-child vaccination, the hepatitis B vaccination should be completed again according to the procedures of 0, 1 and 6 months, and the hepatitis B surface antibody of the children should be monitored after 1-2 months. If no antibody is produced, the success rate should be improved by increasing the number and dosage of vaccination.

In addition, Director Jiang also introduced: "With the progress of the times, there are better ways to block mother and child. The’ Zero Mother-to-Child Transmission Project of Hepatitis B’ was launched in China, and even Hunan Province joined the plan. Improving the mother-to-child blocking rate can also monitor the HBV-DNA titer at the 24th week of pregnancy. When the HBV-DNA titer is greater than 105UI/mL, the pregnant mother will be given antiviral treatment, and then the newborn will be given hepatitis B vaccine and hepatitis B immunoglobulin vaccination plan. Common antiviral drugs are tenofovir, entecavir and lamivudine. Among them, tenofovir can be used not only during pregnancy, but also during lactation. "

On July 28th, World Hepatitis Day, a message to hepatitis B patients.

(Click on the video to view)

Viral hepatitis includes hepatitis A, B, C, D and E. Hepatitis C is curable, and hepatitis B is also controllable, preventable and treatable.

For the majority of patients with hepatitis B, once they find themselves infected with HBV, they should go to the hospital for regular examination and make standardized diagnosis and treatment under the guidance of doctors.

For patients with hepatitis B infection in their immediate family members, they should also go to the hospital actively to prevent aggregation transmission and get diagnosis and treatment in time.

For ordinary people, they should actively go to the hospital for examination, and actively replant or inoculate hepatitis B vaccine when there is no hepatitis B surface antibody or the hepatitis B surface antibody is low.

For medical staff, we should increase publicity, not only for patients, but also for doctors in non-infectious departments and non-hepatology departments, deepen the awareness of people with viral hepatitis and actively treat viral hepatitis.

Only with the joint efforts of all, can we achieve the goal of eliminating viral hepatitis in 2030 proposed by the World Health Organization.

Expert introduction

Director Jiang Yongfang

Director of Hunan Engineering Research Center for New Artificial Liver

Director, Department of Infectious Diseases/Department of Infectious Diseases/Liver Disease Center, Xiangya Second Hospital, Central South University

Deputy Director, Institute of Liver Diseases, Central South University

Member of Infectious Diseases Physician Branch of Chinese Medical Doctor Association.

Member of Fatty Liver and Alcoholic Liver Disease Branch of Chinese Medical Association.

Member of end-stage liver disease group of liver disease branch of Chinese Medical Association.

Member of Bacteriology and Fungology Section, Infectious Diseases Branch of Chinese Medical Association.

Young Member of the Seventh Hepatology Branch of Chinese Medical Association

Standing Committee member of liver disease professional Committee of China Research Hospital Association

Member of the Professional Committee of Liver Diseases of China Medical Education Association

Vice Chairman of Liver Disease Professional Committee of Hunan Medical Association

Vice Chairman of Infectious Diseases Professional Committee of Hunan Medical Association

Deputy Editor-in-Chief of GUT Chinese Liver Disease Special Issue.

Engaged in the diagnosis and treatment of liver and infectious diseases, as well as pathological diagnosis of difficult liver diseases.

Mainly engaged in the study of oxidative stress involved in the pathogenesis of viral hepatitis, fatty liver and liver fibrosis. He presided over 4 national-level projects such as the National Natural Science Foundation, the "Twelfth Five-Year Plan" and "Thirteenth Five-Year Plan" sub-projects. The first finisher won the second prize of Hunan Natural Science Award, the third prize of Science and Technology Progress Award and the third prize of Medical Science and Technology Award. Published 30 SCI papers including GUT and HEPATOLOGY.

References:

[1] Wang Guiqiang, Duan Zhong Ping, Wang Fusheng, et al. Guidelines for prevention and treatment of chronic hepatitis B (2019 edition) [J]. Journal of Practical Liver Diseases, 2020.

This article starts: medical digestive liver disease channel

Author: Jiu Lu

Audit of this article: Director Jiang Yongfang, Department of Infectious Diseases, Xiangya Second Hospital, Central South University.

Editor in charge: XU

More exciting content of World Hepatitis Day will be sent to the doctor’s station app first, welcome to scan the QR code to download, and the exciting content will be "fresh"!

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Original title: "Hepatitis B vaccine is not lifelong immunization, please keep this vaccination guide! | Interview with Professor Jiang Yongfang

Read the original text

Due to historical reasons, China’s automobile brands have been lagging behind foreign brands in the field of traditional fuel vehicles, and these independent brands have been on the road of catching up with foreign brands. However, regardless of the national policy or the development of the times, the era of traditional fuel vehicles is coming to an end, and history has not given China’s independent brands too much time to catch up and surpass in the field of traditional fuel vehicles, which is also a pity for many independent brands and Chinese people. Fortunately, the rise of new energy vehicles has given independent brands the opportunity to "overtake in corners", and many independent brands have seized this opportunity to surpass foreign brands. Among them, the polar fox car from Beiqi Blue Valley is an independent brand model that walks at the top of new energy vehicles and leads the industry in high-level intelligence.

The polar fox auto start is late, but the starting point is high.

Compared with other new energy brands, Extreme Fox started late, but the starting point was high. On the one hand, it is backed by Beiqi Blue Valley, and it has an excellent technical foundation since it was born. It is one of the few new energy automobile enterprises in China that have mastered the core technology of the three-electric system of pure electric vehicles and the integrated matching technology of the whole vehicle, and through the reserve of technology and talents, it has rapidly realized the positive development of motorized vehicles and autonomous driving technology. And these high-tech research and development and reserves also provide more powerful technical support for the follow-up development of Extreme Fox.

On the other hand, Extreme Fox has also cooperated with Magna Factory, which has more than 100 years of high-end automobile manufacturing experience and history, introduced a world-class manufacturing standard system, built a factory with Industry 4.0 standard from the aspects of management mechanism, quality control and cost control, and ensured that the product quality reached the world’s high-end level, all of which ensured that Extreme Fox Automobile was actually "born with a golden key" and was ahead of other domestic, joint venture and even imported competitors in terms of technology and quality.

Extremely fox automobile realizes the lead of high-order intelligent track.

The pursuit of domestic and foreign brands in the field of car-making has enabled Extreme Fox to lead the industry in terms of performance and quality. In addition, Extreme Fox has increased its research and development efforts in the mainstream intelligent field, especially the deepening cooperation with Huawei, which has brought Huawei’s cutting-edge intelligence to the ground, so that Extreme Fox automobile products can also lead the market in the intelligent field and lead new energy vehicles to a higher level of intelligence.

The new HI version of Extreme Fox Alpha S is a great achievement of cooperation between Extreme Fox Automobile and Huawei in the field of intelligence. As the world’s first production car equipped with Huawei’s HI full-stack smart car solution, the world’s first production car supporting high-order intelligent driving on urban roads, and the world’s first luxury pure electric car equipped with Huawei’s HarmonyOS OS intelligent cockpit, the new HI version of Extreme Fox Alpha S has a higher level of intelligent driving and a more advanced intelligent perception ability than other new energy vehicles on the market. Its arrival also indicates that new energy vehicles have entered a new intelligent era.

Extremely Fox Cars Create an Ecological Circle of Friends in the Smart Car Industry Chain

In addition to cooperating with Huawei, Extreme Fox Auto has an open mind, built a circle of friends covering the ecology of the smart car industry chain around the smart car industry chain on the principle of "complementary advantages and win-win cooperation", including deepening joint ventures with giants such as Daimler and Bosch, taking advantage of the technology and market advantages of both parties, constantly improving the cooperative management mechanism, strengthening product research and development, and developing new technologies, thus forming a partnership with mutual priority and a highly coordinated development model.

We have made great efforts in the field of car-building, at the same time, we have seized the opportunity of smart trends, coordinated the world’s top resources, and carried out in-depth cooperation with international giants, all of which have created the industry leader in quality, performance, intelligence and other aspects of the products of Extreme Fox Automobile. The attitude of making cars, which constantly breaks through the boundaries between products and industries, is constantly leading the innovation of new energy smart car technology, and at the same time, it also helps the new rise of China automobile industry.

　　[News] On April 9, 2006, FAW held the official launch conference of the new car in Shanghai, and announced the price. There are 8 sagitar models listed this time, with the price ranging from 173,800 to 216,800.

　　FAW-Volkswagen said that sagitar sedan will provide users with a variety of optional combinations in full accordance with the order system from the date of listing, fully meeting the multi-level personalized needs of users.

　　There are 8 sagitar cars on the market this time, including: 5-speed manual fashion/luxury, with a price of 197,800 yuan/203,800 yuan; 1.8T 6-speed automatic hand-in-one fashion/luxury, with a price of 210,800 yuan/216,800 yuan; 2.0L 5-speed manual fashion/comfort type, the price is 173,800 yuan/179,800 yuan; 2.0L 6-speed automatic manual integration is fashionable/comfortable, and the price is 186,800 yuan/192,800 yuan. And there are blue, candy white, whirlwind red, ebony black, bright silver, pearlescent laser blue, combined gray and other colors for consumers to choose from.

　　The specific price is as follows:

Sagitar car system	Price (ten thousand yuan)
2.0L manual fashion	17.38
2.0L manual comfort	17.98
2.0L automatic fashion	18.68
2.0L automatic comfort	19.28
1.8T manual fashion	19.78
1.8T Manual Deluxe	20.38
1.8T automaticfashion	21.08
1.8T automatic luxury	21.68

　　Since the nationwide booking was accepted on February 25th this year, the sagitar car market has performed well. As of April 9th, the number of orders has exceeded 9,000, and many consumers who have already booked sagitar cars can pick up their existing cars from now on.

　　As the orthodox inheritor of German genes and another masterpiece of PQ35 platform, sagitar sedan adopts the brand-new design concept of German Volkswagen, which is calm internally and fashionable in appearance. It takes "German high-performance car" as its product positioning, "being a strong person" as its brand personality, and its target users are directed at the fashion elite, aiming to become a leader in the same class.

A model of high performance and high quality!

Central control of sagitar 1.8T automatic transmission model.

Sagitar 1.8T automatic transmission engine

　　Among them, sagitar 2.0 is equipped with a 2.0-liter gasoline engine, with a maximum of 85kW/5200rpm and a peak of 170 Nm/4000 rpm; The sagitar 1.8T is equipped with a 1.8-liter engine with a maximum power of 110/5800rpm, which can continuously output a peak torque of 220Nm between 2000 and 4600 rpm.

In [Autohome Shenzhen Discount Promotion Channel], a much-talked-about model is going through a big promotion in Shenzhen. According to the latest news, consumers can enjoy a car purchase subsidy of up to 18,000 yuan, which makes the minimum starting price of Xingtu Lanyue drop to 175,900 yuan. This is a great opportunity not to be missed. Friends who want to take advantage of this discount, please be sure to click "Check Car Price" in the quotation form to get more specific preferential policies.

The exterior design of Xingtu Lanyue shows a unique sense of modernity and power. On the front face, it adopts an atmospheric family-style design, and the iconic air intake grille adopts a large area of chrome decoration, which is integrated with the LED headlight set to give the vehicle a high degree of recognition. In the overall style, the body of Lanyue is smooth and the side profile is full, highlighting the perfect combination of luxury and sports. At the same time, the exquisite craftsmanship in the details further enhances its visual appeal. No matter from which angle, Xingtu Lanyue shows a confident and elegant style, which brings a strong visual impact to the driver.

With its exquisite body proportions and smooth side lines, Xingtu Lanyue shows a unique design beauty. The body size reaches 4970mm x 1940mm x 1792mm, and the wheelbase reaches 2900mm, ensuring a spacious riding space in the car. The front and rear wheel tracks are 1644mm, reflecting good stability and handling. Its tire specification is 245/50 R20, and the combination of tires and rims not only enhances the driving performance, but also gives the vehicle an elegant appearance style.

The interior design of Xingtu Lanyue highlights the sense of luxury and technology, using exquisite leather materials to create a comfortable and high-end driving atmosphere. The steering wheel is wrapped in leather, providing a good grip, and supports manual up and down and front and rear adjustment, which is convenient for drivers to adjust according to their needs. The center console is equipped with a large 15.6-inch screen, which clearly displays multimedia information, navigation system, phone, etc., and integrates automatic speech recognition function, which greatly enhances the convenience of operation.

The technological elements of the interior don’t stop there. Xingtu Lanyue is also equipped with USB and Type-C ports. There are 2 in the front row and up to 3 in the back row, which is convenient for passengers to connect to various electronic devices. The wireless charging function of mobile phones is located in the front row, which brings more convenience to daily use. In terms of seats, the main and passenger seats support front and rear adjustment, backrest adjustment and high and low adjustment, and the front seats are also equipped with heating and ventilation functions to ensure the comfort of drivers and passengers.

In addition, the driver’s seat also has a power seat memory function, allowing the driver to quickly find the most comfortable sitting position. The second row of seats also supports front and rear adjustment and backrest adjustment, making reasonable use of space, while the seat reclining function provides a flexible space solution for loading large items. The overall interior design takes into account practicality and luxury, bringing a superior riding experience to the occupants.

Xingtu Lanyue is equipped with a powerful 2.0T turbocharged engine with a maximum output of 192 kilowatts. This L4 engine has a strong performance of 261 horsepower, providing plenty of power for the vehicle. With the 8-speed automatic transmission, the driving process is smoother and more efficient, meeting the driver’s needs for power and handling.

Summarizing the owner’s evaluation of Xingtu Lanyue, its exterior design is deeply loved by him, and he believes that the international style it shows is a perfect fit with his personal preferences. The owner appreciates the power performance of the vehicle, emphasizing the strong power and rapid acceleration of its engine, which undoubtedly meets his high requirements for vehicle performance when working on the construction site. Overall, Xingtu Lanyue not only has an atmospheric appearance, but also has excellent internal strength. It is an ideal choice for car owners in Nanchong 1562382.

accelerate brake fuel consumption second rice liter Measured fuel consumption 4.3L test FAW Toyota Corolla Dual Engine Review Editor – Zhang Ke:

We are already very familiar with the hybrid system, the driving experience is relatively smooth, and driving in urban areas is very fuel-efficient. In fact, the biggest highlight is the price. This is the first time the hybrid system has been produced in a country other than Japan, and the cost is greatly reduced, making the hybrid model not too expensive than the conventional power model, and it is easier to get back the cost! If you often drive in urban areas, it is recommended to buy

Review Editor – Li Jia:

The sales of the gasoline version of the Corolla are already quite eye-catching at this level, so I am not worried about the market performance of the Corolla Dual Engine, because it is only a little more expensive than the ordinary gasoline version of the Corolla, but it is definitely a high-value, low-cost Corolla. If you don’t pay attention to the power flow diagram on the dashboard during daily driving, you can basically drive it as an ordinary gasoline version of the Corolla.

Review Editor -:

As a family car that focuses on economy, the performance of the Corolla Duo Engine is very satisfactory. Although the power is not outstanding, it can also meet the needs of urban transportation. The key point is the super economy, which makes people impeccable. Overall performance, I think it is not too much for the Corolla Duo Engine to get nine points. But unfortunately, in most areas, the Corolla Duo Engine is not included in the scope of subsidies for new energy vehicles, which is quite a pity, because the Duo Engine power does not need to rely on charging piles, it only needs to be refueled, and it has the advantages of more fuel-efficient traffic congestion, and the technology is mature. It can only be said that it is a bit "born at the wrong time".

On September 25, 2024, the second generation was officially launched. The new car launched three models, priced from 199,900 yuan to 229,900 yuan. The second generation Haval H9 was built on a tank platform and was positioned as a medium and large hard SUV, equipped with a 2.0T engine, body, and powerful four-wheel drive capability.

The listing of Haval H9 launched a total of three models, namely the exploration version, the expansion version and the extreme version, priced at 199,900 yuan, 215,900 yuan and 229,900 yuan respectively. Compared with the pre-sale price, the price of the new car has been reduced by 6,000 yuan, showing Great Wall Motor’s sincerity to the market and feedback to consumers. In addition, the factory also provided a replacement subsidy policy. The replacement subsidy for the old H9 model is as high as 20,000 yuan, and the replacement subsidy for other models is also 15,000 yuan, which further reduces the threshold for consumers to buy cars.

As a new generation model, the second-generation Haval H9 has been greatly upgraded in appearance, interior and power performance. The new car adopts the popular "square box" design, showing a tough and retro visual effect. The front grille is composed of four thick chrome-plated trims, and the center is inlaid with the "HAVAL" letter logo. With the retro-style square headlight set and round LED daytime running lights, the overall design is both rough and exquisite. The side of the body continues the body structure, and the straight waist line runs through the whole body, showing a slender and tough posture. At the rear of the car, the new car adopts an external spare tire and a longitudinal distribution of tail light sets. The tailgate is a side-opening design, and the overall shape complements the tough style of the body.

In terms of interior, the second-generation Haval H9 has also undergone a comprehensive renovation. The interior of the new car adopts a new design, and the layout is rough without losing the sense of technology. Equipped with a new steering wheel and a 14.6-inch floating center control screen, it improves the visual effect and operation convenience in the car. The sub-dashboard position adopts the same shift lever design as other models, and there are physical buttons and knobs around it, which is convenient for the driver to operate when off-road. The seat layout is available in 5-seat and 7-seat versions for consumers to choose from, and it is equipped with a panoramic sunroof, which further enhances the comfort and sense of space in the ride.

Off-road, the new car approach angle of 31 degrees, departure angle of 26 degrees, wading depth of 800mm, ground clearance of 224mm, can climb 45 degrees slope. Equipped with 7 driving modes such as standard, sports, economy, snow, mud, sand, 4L, etc., support tank turn-around, low-speed off-road cruise, transparent chassis and other functions. Torque can be enlarged by 2.64 times in low-speed four-wheel drive mode, and torque capacity is increased from 1200N · m to 1900N · m. The application ratio of high-strength steel in the body skeleton is 83%, which ensures the torsional stiffness of the body.

In terms of power, the new car is currently equipped with a 2.0T gasoline engine with a maximum power of 165 kilowatts, a peak torque of 385 Nm, and an 8-speed automatic transmission. The powertrain not only guarantees the vehicle’s strong power output, but also provides a smoother driving experience. In the future, Great Wall Motors also plans to launch models equipped with a 2.4T diesel engine to meet the needs of different consumers.

Haval H9, as the flagship SUV model of Great Wall Motor, has won the love and recognition of consumers with its excellent off-road performance, comfortable space experience and affordable price. The second-generation Haval H9 listed this time has been fully upgraded in appearance, interior and power performance. Can Haval H9 continue its brilliance in the 200,000-level market? We will wait and see!

With the release of the new MIIT declaration information, we have also seen the figure of a new car from Geely. The new car is named Xingyuan, which is a new pure electric small car. The new car uses a new pure electric platform, and the new design also makes it look more fashionable and interesting. It is understood that Geely Xingyuan will use lithium iron phosphate batteries, and also has an independent suspension design. The new car is expected to be launched in the third and fourth quarters of this year.

From the announcement picture, Geely Xingyuan adopts a new design language, with smooth and smooth body lines. It can be said that in the field of small pure electric cars, more youthful design ideas are integrated, and the golden body ratio of the new car creates a full and tense dynamic beauty. In addition, in terms of details, the new car adopts a closed front grille, and both sides are also equipped with headlights similar to rounded polygons and double C-shaped diversion grooves on both sides, which further strengthen the sporty characteristics. The size of the new car body is 4135 × 1805 × 1570mm, and the wheelbase is 2650mm.

Looking at the side of the car, Star Wish has front and rear raised eyebrow lines, hidden door handles, low wind resistance wheels, and a two-color body design, making the overall look very young. In the rear design, the new car also uses a tail light set similar to a rounded triangle, which echoes the front of the car very well.

According to relevant information, Geely Star is built on a new pure electric platform. In terms of power, the car is equipped with a lithium iron phosphate power battery, and the electric motor has two powers, 58kW and 85kW respectively. And for further information on the new car, we will continue to pay attention.

With the opening of the central heating curtain, many places have officially entered the "heating time". China Electric Technology’s digital intelligence solutions are widely used in energy, power and other industries to provide technical support for keeping warm and supply, and to send "warm happiness" to the people.

Walking into the smart heating network dispatching command center, on one side of the large screen, the total amount of steam supply, total steam consumption, total heat supply, total heat consumption, energy consumption analysis, alarm information, etc. The on-site staff monitored the data and carefully recorded the operating indicators… This is the "smart brain" of Shiyan City’s winter heating.

"Compared with traditional heating, smart heating emphasizes the application of emerging technologies such as the Internet of Things and big data." According to technical experts from China Electric Technology, the company’s innovative "TECO Industrial Internet + Smart Heating Network" not only performs digital intelligent transformation of pipelines, equipment, meters, control and regulation equipment in the heating system, but also introduces technologies such as the Internet of Things and big data. It independently develops the DataKeeper industrial data platform and builds more than 20 models such as a network hydraulic calculation model, a heating load prediction model, and a cost accounting model, allowing the dispatching center to accurately and real-time understand every aspect of heating, and even provide services more efficiently according to the needs of each household.

Make the heating system smart. "This’source-network-station-household ‘intelligent scheduling mode makes the heating station start and stop with one click, unattended, and promotes the refined and energy-saving operation of the heating system." According to technical experts from China Electric Technology, the system meets the smart heating demand of the 860-ton/hour steam heating system, reducing the heat consumption per unit area by nearly 10%, reducing the heating network loss by 12%, and comprehensively improving the heating capacity and service level.

"The power supply of the system is normal, so we can rest assured. The weather is so cold, we dare not have any problems with heating." In the cold winter, electric heating, as an efficient and environmentally friendly heating method, is increasingly accepted by the majority of users.

In order to protect the safe conversion of each kilowatt-hour of electricity, the intelligent inspection system of power plants supported by China Electric Power Technology has realized the digital upgrade of inspection work and made full preparations for the peak heating electricity consumption in winter.

In the fuel area, the intelligent inspection system can calculate the cross-sectional volume of the coal pile on the belt before and after entering the coal drop pipe, compare the coal volume passing through the inner belt per unit time, and determine whether the phenomenon of coal blocking and coal spilling occurs. The management staff will be notified as soon as possible to deal with it. The addition of multi-dimensional sensing technologies such as video and laser allows the symptoms of belt tearing to be detected in time at the early stage. In the production area with a more difficult environment, intelligent machines, intelligent cameras, thermal imaging online temperature measurement equipment and video intelligent analysis are "stationed" 24/7, not only to achieve "visible" temperature measurement, but also to solve the annoying "running and dripping" problem with intelligent IoT technology.

Gas is ignited, electricity becomes heat, and these energy sources have "traveled" thousands of miles when they are used. In the process of electricity and gas transmission, they often pass through the transit hub – the station valve chamber. For the station valve chambers that are often built in remote areas, China Electric Technology uses digital technology to build an intelligent sensing system to solve the needs of buried pipeline leaks "not visible", gas leaks "not audible", and manual quick judgment.

"The station valve chamber plays an important role in the networking and control regulation of long-distance pipelines, but over time, there will be leaks and leaks." According to technical experts from China Electric Technology, manual inspections often encounter problems such as real-time monitoring difficulties and difficulty in judging hidden dangers. The self-developed positioning-type vibration optical fiber senses the environmental status around the pipeline in real time, and sends an early warning signal in time when there is an external force touch. The positioning-type temperature measurement optical fiber senses the temperature change of the pipeline in real time, and judges and locates the leakage of gas and liquid in the pipeline. Industrial auscultation microphones, sonographs, etc., extract mechanical voiceprints in real time, intelligently judge the status and fault type of equipment, and fully safeguard the safety of energy pipelines.

[Editor in charge: Yu Zhaojun]