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Fibroblasts are diverse interstitial cells, which create signal niches by producing complex extracellular matrix and biophysical and biochemical clues, and participate in tissue balance and diseases. Fibroblasts have diverse lineages and a wide range of uses, but our understanding of these cells, which fill a considerable part of the human body, is still not comprehensive. Next, let’s understand the mysterious and fascinating fibroblasts from four aspects and embark on a human journey across time and space.

Definition of fibroblast

The term "fibroblast" refers to the following kinds of cells: (1) cells that secrete many macromolecules with the same structure and signal as the extracellular space of tissues; (2) Adopting the phenotype of myofibroblasts that contract instantaneously when dealing with tissue injury; (3) signal niche cells as resident stem cells; (4) As the progenitor cells of specialized differentiated interstitial cells, they are sometimes called mesenchymal stem cells (Lemos and Duffield, 2018; Pittenger et al. , 1999, 2019）。

Fibroblasts create and maintain anatomically diverse connective tissue rich in extracellular matrix (ECM) to support a wide range of basic organ functions, such as resisting blunt and sharp skin injuries, stretching and elastic retraction in the organ range of lung, etc. In addition to producing connective tissue, fibroblasts serve as the progenitor cells of specialized interstitial cell types during embryonic development, adult homeostasis, injury, repair and remodeling, such as osteoblasts forming bones or fat cells filled with lipids.

The origin and development of fibroblasts

In 1858, German pathologist Rudolf Virchow first described fibroblasts as a unique cell type, which he called "Spindelzellen des Bindegewebes"-"Spindle cells of connective tissue" (Virchow, 1858；; Fig. 2A). Ernst Ziegler first put forward the term "fibroblast" to describe cells that produce new connective tissue after healing (Ziegler, 1895；; Fig. 2B), this observation was replicated by Santiago Ramón y Cajal, who observed that "célula fusiforme" or "fibro-células" are important producers of granulation tissue in skin wound healing and scar (Cajal, 1986；; Fig. 2C). The appearance of in vitro technology developed in the 1900 s promoted the research of fibroblasts. These methods allow primary fibroblasts from embryonic chicken heart explants to be cultured, and these cells can easily propagate before other cell types after passage (Burrows and Neymann, 1917; Carrel, 1912; Ebeling, 1913; Hogue, 1919； Fig. 2D). More than 50 years later, 3T3 fibroblast cell line from mouse embryo was established (Todaro and Green, 1963; Todaro and others,1964) further promoted our understanding of the biological and genealogical potential of fibroblasts. These findings include the identification of fibroblast growth factor (FGFS) (Gospodarovicz, 1974); Multi-line differentiation of cultured fibroblasts into bone, cartilage and fat cells (Junker et al., 2010); And the key role of fibroblasts in the production, remodeling and contraction of ECM.

Although there are a lot of studies on fibroblasts in vitro, the in vivo correlation of these cells is still unclear, and the real characteristics of fibroblasts and their pedigree potential in the in vivo primary environment have only recently been deeply explored. New evidence shows that fibroblasts have promoted major changes in the tumor-related environment, which has been widely reviewed elsewhere (Sahai et al., 2020).

Organ specificity of fibroblasts

The existence of tissue-specific fibroblast function and lineage can support the development, homeostasis and repair needs of specific organs. During embryonic development, multiple cell lines coalesce to form fibroblasts, which are filled with organs from all three somatic germ layers, such as skin and breast derived from ectoderm, skeletal muscle or myocardium derived from mesoderm, and lungs derived from endoderm. When fibroblasts proliferate in specific organs, they will produce unique microstructure, biophysical and biochemical components of connective tissue.

In organs rich in epithelial cells (for example, skin and lungs), fibroblasts in the skin produce a mechanically elastic, viscous and elastic structural foundation, which supports the epithelial cells of the outward layered epidermis and its many appendages, mainly hair follicles and sweat glands. Fibroblasts and other mesenchymal cell lines in the skin have established three anatomically different layers: papillary dermis, reticular dermis and dermal white adipose tissue (dWAT) (Figure 5A). Skin epithelial cells are derived from ectoderm, which has a unique level of connectivetissue. In contrast, lung epithelium originated from endoderm, forming a highly branched tree and eventually forming an inflatable sac called alveoli. The gas exchange function of lung depends on the close physical connection between alveolar epithelium and extensive capillary network, and on the repeated and rapid expansion and contraction ability of lung. These functions require the reticular ECM of the lung, which has the best viscoelasticity, but is strong enough to withstand the change of air pressure and prevent alveolar rupture and potentially fatal air pressure trauma. With the maturity of the lung, the lung mesenchymal progenitor cells assume different spatial positions and functions, including smooth muscle cells around bronchi and blood vessels, pericytes, numerous interstitial fibroblasts, adipocytes supporting lung cells and mesothelial cells of visceral pleura (Peng et al., 2013; Fig. 5B).

In interstitial organs (such as skeletal muscle and heart), unlike skin and lung, skeletal muscle has no epithelial structure, but is composed of large, highly differentiated and multinucleated muscle fibers arranged in parallel, and its main function is to generate strength through contraction. The connective tissue in muscle has a complex layered tissue. Its innermost layer is called endocardium, which surrounds a single muscle fiber and contains a special basement membrane rich in laminin and collagen IV. Laminin acts through its transmembrane receptor, helping the mechanical force to be transmitted from the intracellular contraction device to the inner muscle layer rich in collagen I and III (Chapman et al., 2016). Muscle fiber group is called bundle, surrounded by perimuscular layer, which forms a continuum with tendon, and is rich in so-called perimuscular layer "cable", that is, thick connective tissue bundle mainly composed of closely arranged type I and type III collagen III fibers. Finally, the whole muscle is wrapped by the connective tissue layer of the adventitia (Chapman et al., 2016). Myocardium is an anatomically and physiologically complex contractile organ. Its main cell group, cardiomyocytes, are connected with each other, and an electrically coupled tissue is formed through the sandwich disc that constitutes its middle layer, which is called myocardium. The heart is also rich in fibroblasts, which produce and reshape a powerful ECM network, which is very important for conductivity and heartbeat rhythm. In addition to myocardium, fibroblasts also exist in the outermost epicardium, which contains specialized adipose tissue, and the innermost endocardium, with a layer of endothelial cells at its edge.Unlike most other organs’ fibroblasts, which originated from mesenchymal progenitor cells through gradual standardization, most cardiac fibroblasts are formed through EMT, and fibroblasts located in interventricular septum and right ventricle are products of EndMT (Gittenberger-de Groot et al., 1998; Fig. 5D).

Application of fibroblasts in diseases

At present, the approved anti-fibrosis therapy is aimed at the activation of fibroblasts in established diseases and cannot restore the structure and function of diseased tissues. Therefore, developing strategies to promote the repair of damaged tissues will greatly promote the development of this field.

Although the plasticity of fibroblasts may be problematic in the context of fibrotic diseases, it also provides opportunities for regenerative intervention. Recently, this understanding has promoted the development of in-situ reprogramming into fibroblasts by molecular strategy to restore tissue anatomy and function (including direct reprogramming). In skin wounds, the innate ability of fibroblasts to support hair follicle regeneration can be induced by transcription reprogramming.

Examples have proved that the principle of therapeutic reprogramming of fibroblasts in vivo can be realized in liver and heart, such as transferring transcription factors such as Foxa3, Gata4, Hnf1a and Hnf4a to myofibroblasts in liver through viruses, reprogramming them into hepatocyte-like cells, and reducing the signs of liver fibrosis in mouse models (Rezvani et al., 2016; Song et al., 2016). The above examples clearly emphasize the therapeutic potential of reprogramming tissue-resident fibroblasts directly into "working" cells, and suggest it as a new scar replacement strategy. However, there are still several important problems to be solved, including the efficiency of reprogramming factor delivery using non-integrated vectors and high fibroblast specificity (if not exclusiveness), in order to transform this attractive method into safe clinical application.

Conclusion and prospect

In the past decades, our understanding of fibroblast biology under different organs and conditions has made remarkable progress. New methods and techniques have made this field develop from phenotypic study of cultured cells more than a century ago to complex genetic and functional observation in vivo. These advances reveal that fibroblasts from different organs (such as skin, lung, heart and skeletal muscle) have unexpected similarities and unique characteristics, so they are currently used to treat human diseases.

While great progress has been made, many problems and opportunities still exist. For example, the ongoing efforts to adopt single-cell omics and space genomics technologies will provide key insights into the heterogeneity of fibroblasts within and between tissues, and their ability to assume multiple functional States for physiological or disease triggers. With our understanding of the basic function of fibroblasts far beyond the scope of ECM synthesis, in-situ regulation of fibroblasts can bring new therapeutic possibilities for a wide range of diseases characterized by aging, pathological remodeling and tissue fibrosis. New research fields, including cross-regulation between wound fibroblasts, immune cells and peripheral nervous system, are very important for understanding how to restore tissues to their pre-injury state. Finally, effective clinical transformation will require rigorous verification in local human tissues and human-like models, such as organotypic cultures, xenotransplantation and organs derived from pluripotent cells. These advances will make it possible to prevent, treat and even reverse fibrosis through proper and controlled repair.

Related paper information

The original paper was published in Cell, a periodical of CellPress Cell Press. Click "Read the original" to view the paper.

▌ Paper title:

Fibroblasts: Origins, definitions, and functions in health and disease

▌ Website of the paper:

https://www.cell.com/cell/fulltext/S0092-8674(21)00792-3

▌DOI：

https://doi.org/10.1016/j.cell.2021.06.024

Read the original text

　　Cctv news: On June 14th, the State Council held a press conference on the operation of the national economy in May. Fu Linghui, spokesperson of the National Bureau of Statistics, introduced the operation of the national economy in May 2019 and answered questions from reporters. It is reported that this is also the first time that Director Fu has met with reporters.

　　Fu Linghui introduced at the meeting that in May, the national economy continued to operate in a reasonable range, continuing the overall stable, steady and progressive development trend.

　　First, the service industry continued to grow, and the emerging service industry developed in depth.

　　In May, the national service industry production index increased by 7.0% year-on-year, and the growth rate dropped by 0.4 percentage points from the previous month. From January to May, the national service industry production index increased by 7.3% year-on-year, 0.1 percentage point lower than that in January-April, and the same as that in January-February. In May, information transmission, software and information technology services, leasing and business services increased by 22.2% and 8.4% respectively year-on-year, and the growth rate was faster than the national service industry production index by 15.2 and 1.4 percentage points respectively. The business activity index of service industry was 53.5%, up 0.2 percentage points from last month, and remained above threshold. The business activity indexes of railway transportation, air transportation, postal service, accommodation, telecommunications, broadcasting, television and satellite transmission services, and Internet software and information technology services are all in the higher boom zone of more than 60.0%. The expected index of service business activities is 59.5%, which is at a high level.

　　Second, industrial production has increased steadily, and high-tech manufacturing has grown rapidly.

　　In May, the added value of industrial enterprises above designated size increased by 5.0% year-on-year, and the growth rate dropped by 0.4 percentage points from last month. From January to May, the added value of industrial enterprises above designated size increased by 6.0% year-on-year, and the growth rate dropped by 0.2 percentage points from January to April. In terms of economic types, in May, the added value of state-owned holding enterprises increased by 3.7% year-on-year, joint-stock enterprises increased by 6.6%, and foreign-invested enterprises from Hong Kong, Macao and Taiwan decreased by 0.3%. In terms of three categories, the added value of mining industry increased by 3.9% year-on-year, manufacturing industry increased by 5.0%, and electricity, heat, gas and water production and supply industries increased by 5.9%. The added value of high-tech manufacturing increased by 9.4% year-on-year, 4.4 percentage points faster than that of industries above designated size; The output of new energy vehicles and solar cells increased by 16.0% and 9.9% respectively. In May, the manufacturing purchasing managers index (PMI) sub-index, the production index and supplier delivery time index were 51.7% and 50.9%, respectively, both above the critical point.

　　Third, the growth rate of market sales accelerated, and the proportion of online retail continued to increase.

　　In May, the total retail sales of social consumer goods was 3,295.6 billion yuan, up 8.6% year-on-year, and the growth rate was 1.4 percentage points higher than that of last month. According to the location of business units, the retail sales of urban consumer goods was 2,830.4 billion yuan, an increase of 8.5% year-on-year; The retail sales of rural consumer goods reached 465.2 billion yuan, up by 9.0%. According to consumption types, catering revenue was 363.1 billion yuan, an increase of 9.4%; Retail sales of commodities reached 2,932.4 billion yuan, an increase of 8.5%. The retail sales of cosmetics, beverages, daily necessities, Chinese and western medicines above designated size increased by 16.7%, 12.7%, 11.4% and 11.2% respectively, which was 8.1, 4.1, 2.8 and 2.6 percentage points faster than the total retail sales of social consumer goods respectively.

　　From January to May, the total retail sales of social consumer goods reached 16,133.2 billion yuan, up 8.1% year-on-year, and the growth rate was 0.1 percentage point faster than that in January-April. The national online retail sales reached 3,864.1 billion yuan, up 17.8% year-on-year, and the growth rate was the same as that in January-April, 2.5 percentage points faster than that in January-March. Among them, the online retail sales of physical goods was 3,041.5 billion yuan, up 21.7%, accounting for 18.9% of the total retail sales of social consumer goods, up 0.3 and 0.7 percentage points respectively from January to April and January to March, and up 2.3 percentage points from the same period of last year.

　　4. Investment maintained growth, and investment in high-tech industries grew well.

　　From January to May, the national investment in fixed assets (excluding farmers) was 21,755.5 billion yuan, up 5.6% year-on-year, and the growth rate was 0.5 percentage points lower than that in January-April. Among them, private investment was 13,082.3 billion yuan, an increase of 5.3%. In terms of industries, investment in the primary industry decreased by 2.3% year-on-year; Investment in the secondary industry increased by 3.2%, of which investment in manufacturing industry increased by 2.7%, 0.2 percentage points faster than that in January-April; Investment in the tertiary industry increased by 7.1%, of which infrastructure investment increased by 4.0%. Investment in high-tech industries grew rapidly. Investment in high-tech manufacturing and high-tech service industries increased by 10.2% and 15.6% respectively year-on-year, and the growth rate was 4.6 and 10.0 percentage points faster than the total investment. From January to May, the national investment in real estate development was 4,607.5 billion yuan, up by 11.2% year-on-year. The growth rate dropped by 0.7 percentage points from January to April and accelerated by 1.7 percentage points over the previous year. The national commercial housing sales area was 555.18 million square meters, down 1.6% year-on-year; The national sales of commercial housing reached 5,177.3 billion yuan, up 6.1% year-on-year.

　　V. The employment situation is generally stable, and the survey unemployment rate is flat.

　　From January to May, 5.97 million new jobs were created in cities and towns nationwide, accounting for 54% of the annual plan. In May, the national urban survey unemployment rate was 5.0%, the same as last month. Among them, the survey unemployment rate of the population aged 25-59 was 4.5%, which was 0.2 percentage points lower than that of the previous month and dropped for three consecutive months. The survey unemployment rate in 31 big cities and towns was 5.0%, which was the same as last month. The average weekly working hours of employees in enterprises nationwide were 46.3 hours, an increase of 0.5 hours year-on-year.

　　Six, the consumer price rose moderately, and the price increase of industrial producers fell back.

　　In May, the national consumer price rose by 2.7% year-on-year, an increase of 0.2 percentage points over the previous month, which was the same as the previous month. By category, the prices of food, tobacco and alcohol rose by 5.8%, clothing by 1.7%, housing by 1.8%, daily necessities and services by 1.0%, transportation and communication by 0.9%, education, culture and entertainment by 2.6%, medical care by 2.5% and other goods and services by 2.1%. After deducting food and energy prices, the core CPI rose by 1.6%, down 0.1 percentage point from last month. From January to May, the national consumer price rose by 2.2% year-on-year.

　　In May, the ex-factory price of industrial producers nationwide rose by 0.6% year-on-year, down by 0.3 percentage points from the previous month and up by 0.2% from the previous month. The purchase price of industrial producers nationwide rose by 0.2% year-on-year, which was flat from the previous month. From January to May, the ex-factory price and the purchase price of national industrial producers rose by 0.4% and 0.2% respectively.

　　7. Exports maintained rapid growth and the trade structure was constantly optimized.

　　In May, the total import and export volume was 2,592.5 billion yuan, a year-on-year increase of 2.9%. Among them, exports were 1,435.8 billion yuan, an increase of 7.7%; Imports reached 1,156.7 billion yuan, down 2.5%. Import and export balance, trade surplus of 279.1 billion yuan, an increase of 89.8%. From January to May, the total import and export volume was 12,104.1 billion yuan, a year-on-year increase of 4.1%. Among them, exports were 6,498.7 billion yuan, an increase of 6.1%; Imports reached 5,605.3 billion yuan, up by 1.8%. The structure of trade mode was further optimized. From January to May, the import and export of general trade increased by 6.1% year-on-year, accounting for 59.9% of the total import and export, up by 1.1 percentage points over the same period of last year. The import and export of private enterprises increased by 11.1%, accounting for 41.4% of the total import and export, an increase of 2.6 percentage points over the same period of last year. From January to May, industrial enterprises above designated size achieved a export delivery value of 4,763.4 billion yuan, a year-on-year increase of 4.4%.

　　8. Deepening structural reform on the supply side and improving the efficiency of service enterprises.

　　At the end of April, the asset-liability ratio of industrial enterprises above designated size was 56.8%, down 0.5 percentage points year-on-year. Commercial housing inventory decreased. At the end of May, the area of commercial housing for sale in China was 509.28 million square meters, down 9.1% year-on-year, down 4.53 million square meters from the end of April. The unit cost of enterprises is lower than that at the beginning of the year. Investment in the short-board sector has increased. From January to May, the investment in ecological protection, environmental management and education increased by 41.5% and 15.4% respectively, which was 35.9 and 9.8 percentage points faster than the total investment.

　　From January to April, the operating income of service enterprises above designated size increased by 9.8% year-on-year, among which the strategic emerging service industry, science and technology service industry and high-tech service industry increased by 12.1%, 11.9% and 11.9% respectively, which were 2.3, 2.1 and 2.1 percentage points faster than all service industries above designated size. The operating profit of service enterprises above designated size increased by 9.2% year-on-year, and the growth rate was 0.8 percentage points higher than that of the same period of last year. From January to April, the operating income of industrial enterprises above designated size increased by 5.1% year-on-year, and the total profit decreased by 3.4% year-on-year. From January to April, the profit rate of operating income of industrial enterprises above designated size was 5.52%, 0.21 percentage points higher than that in January-March.

　　Fu Linghui said that, on the whole, the national economy in May was generally stable, steady and progressing, and continued to operate in a reasonable range. At present, the external environment is unstable and uncertain, the problem of insufficient domestic development imbalance is still outstanding, and the foundation of sustained and healthy economic development needs to be consolidated.

On August 1st, the movie "Catch the Doll", with the excellent performances of Shen Teng and Mary, successfully broke through 2.4 billion at the box office, which injected vitality into the recently slightly deserted movie market. The success of this film is largely due to the re-engagement of the golden combination of "Shen Ma+Yan Fei Peng Damo". In the process of constructing the universe of Xihong City, directors Yan Fei and Peng Damo have already proved their strength through goodbye mr. loser and The Richest Man in Xihong City. These works are all from their hands, and they have also won a win-win situation for Mahua FunAge in word of mouth and box office. Back in 2003, Beijing Free Element Film and Television Culture Communication Co., Ltd., the predecessor of Mahua FunAge, was founded by three young people with different backgrounds, including Yu Kai of Chinese Department of Peking University, You Liang Tian of Chinese Opera, and entrepreneur Zhang Chen. At first, they tried to adapt the novel into a TV series, but it failed because of the influence of SARS. Subsequently, You Liang Tian turned to the field of drama, and released his first work, I’ll give you a twist if you want to eat it. Although it was initially challenged by the box office, it finally found its own audience in Haidian Theater with its unique style and word-of-mouth fermentation, and Mahua FunAge became famous.

The addition of actors such as Shen Teng, Allen, Wei Xiang, Song Yang and Du Xiaoyu further enriched the cast of Mahua FunAge, and many of them joined through internal recommendation, forming a stable team foundation. Mary, in particular, attracted the attention of Peng Damo for her outstanding performance in the small theater, and eventually became an indispensable member of Mahua FunAge.

The turning point of Mahua FunAge appeared on the stage of the Spring Festival Evening. The skits written and directed by Yan Fei and Peng Damo, especially the role of "Hao Jian" played by Shen Teng, gradually made the team members familiar to the national audience. Despite the enormous pressure of the Spring Festival Gala, the Mahua FunAge team boarded the Spring Festival Gala for many years with unremitting efforts and unique creativity, which not only enhanced its popularity, but also promoted the development of its members’ personal careers, and Shen Teng became an important figure in China comedy movies.

In 2015, goodbye mr. loser, the first work of Mahua FunAge’s transitional film industry, was a great success, which not only verified the feasibility of adapting drama into film, but also opened a new chapter in Mahua FunAge’s film. Subsequent works, such as The Richest Man in Xihong City, faced with speculation about the change of creative team, but Yan Fei and Peng Damo still insisted on their own creative rhythm and style and continued to introduce popular works.

Looking at the development of Mahua FunAge, from the initial exploration to becoming the backbone of comedy, it is inseparable from the tacit cooperation of the core team and the continuous exploration of comedy art. Whether it’s a stage play or a movie, Mahua FunAge always maintains the pursuit of quality and respect for the audience, and continues to bring laughter to the audience.

Welcome to the Autohome Qingdao preferential promotion channel, revealing an exciting car buying opportunity for you! At present, high-profile models are giving back to consumers with great price discounts. In the bustling city of Qingdao, Blue Electric E5 is conducting an unprecedented promotion, with the highest discount reaching an astonishing 40,100 yuan. Surprisingly, the minimum starting price has been reduced to 99,800 yuan, providing car buyers with a very attractive car purchase option. If you are interested in this model, be sure to click the quotation form below to learn more about the preferential policies, and strive to lock in this rare preferential opportunity as soon as possible to realize your car purchase dream.

The exterior design of the blue electric car series E5 shows a simple and technological style. On the front face, it adopts a unique grille design with smooth lines, which not only highlights the sense of power but also the sense of refinement. The overall shape is stable, fusing futuristic and practical, making people recognize its unique identity at a glance.

The Blue Electric E5 shows its side-facing charm with elegant body proportions. The body size is 4760mm x 1865mm x 1710mm, and the wheelbase reaches 2785mm, ensuring the comfort of the interior space. The front and rear wheelbases are 1585mm and 1580mm respectively, providing a stable driving foundation. The tire specifications are quite balanced. The 225/55 R18 tires are selected, and the delicate wheel design is matched, which not only enhances the driving performance, but also adds to the visual movement of the vehicle.

The interior design of the Blue Electric E5 shows a simple yet luxurious style. The 12.3-inch central control screen stands in front of the driver, which is clear and easy to operate. It integrates multimedia, navigation, telephone, air conditioning and sunroof control to provide convenience for the driver. The steering wheel is made of exquisite leather material, which brings a comfortable grip and supports manual up and down adjustment to adapt to the needs of different drivers. The USB/Type-C interface in the car is reasonably distributed, and there is 1 in the front and rear rows, which is convenient for passengers to connect electronic devices. In terms of seats, imitation leather material is used to provide front and rear adjustment, backrest adjustment and high and low adjustment functions. The main and passenger seats are equipped with this comfortable configuration to ensure the comfort of long-distance driving. The second row of seats also supports backrest adjustment to increase the flexibility of the ride space, while the proportional reclining rear seats provide more practical space. Overall, the interior design of the Blue Electric E5 fully considers practicality and passenger experience.

The Blue Electric E5 is equipped with a 1.5L 110 horsepower L4 engine, which can reach a maximum power of 81 kilowatts, which can meet the daily driving needs. The matching E-CVT continuously variable transmission provides a smooth shifting experience and makes the driving process smoother. The combination of this engine and transmission provides the vehicle with enough power and good fuel economy.

Summarizing the views of Autohome owners, the exterior design of the Blue Electric E5 seems to have won its approval. It is described as atmospheric and smooth, and although it is not particularly stunning, it does not fall into the cliché. This modest SUV seems to be suitable for owners who seek practical and understated beauty. Such evaluations have allowed the Blue Electric E5 to find its place in the market and provide a reliable choice for wold-be users.

1905 movie network news On the evening of July 6, the film premiered in Beijing. The director, director, and other creators interacted with the audience through an online meeting. The heroine, Ah Sa, also appeared in the previous live broadcast.

The story of "Detective Wars" revolves around Liu Qingyun’s role as "Detective Crazy". In serial murders, preview murders and other incidents, he and the "Detective Couple" composed of Ah Sa and Lin Wei engage in fierce confrontations.

The plot of the film is ups and downs and confusing, and Liu Qingyun also exchanged notes of "I am a madman" and "I am a detective" to "confuse" the audience at the scene. When it comes to the shooting of "Detective War", he bluntly said that many scenes were very impressive, but the most memorable is the war at the end. He has been tearing this important scene before shooting, and it is very difficult to complete how to control the emotions and how to bring them in. It seems that the acting skills of "Crazy Guy" are also a great test for Liu Qingyun.

Ah Sa, who is on vacation, also helped out for the new film "Detective War" through live broadcast. Gillian, who is on vacation together, also appeared in surprise to play Call for the film. Joey Yung also actively confessed to her idol Liu Qingyun, revealing that she has been a fan of Wei Jiahui and Liu Qingyun since "The Big Times". "When I debuted, I also wrote that Liu Qingyun was my idol, Prince Charming."

On July 8, "Detective War" will be officially released. As a crime suspense film, director Wei Jiahui also hopes that everyone will not spoiler and walk into the theater to experience this exciting story together.

Recently, Ah Kun has been quite emotional. The knowledge of marketing is really extensive and profound, and many manufacturers will choose to promote their products through cross-border marketing. Friends who like sports and basketball recently must have heard that Geely Crossover Basketball has held Geely Colorful China Steel Cannon Basketball Rising Star Trials. It seems that Geely has understood the cross-border marketing part. Then today’s line photo manga "Driving You to Play" is to take you to play basketball.

In the first match of Chengdu Station from June 26th to 27th, dozens of teams competed for the championship of the sub-station and the place to advance to the national finals. On the 27th, Ah Kun, who was photographed in the comics, was fortunate to have zero-distance contact with CBA star Zhu Songwei and streetball expert SOMA, and felt the scope of the game at the scene.

It is reported that this competition uses a 3 + 1 format, consisting of a 3v3 team competition and a 1v1 individual competition, which not only tests team cooperation, but also compares individual strength. In the preliminary round on June 26, in addition to 36 social teams from Chengdu, 12 car owners teams composed of Colorful Car Owners participated together. In the 3v3 confrontation, the social team Amazing team and the Fourman team finally advanced to the finals on the second day.

In the 3v3 final on June 27, just 7 seconds before the end of the game, Fourman’s Serbian player SpaicFilip staged a lore, and after two shots, he successfully leveled the score and reversed the game. In the subsequent 1v1 singles, SpaicFilip once again staged a buzzer lore, successfully leveling the score, but after the on-site referee confirmed through video replay, because Fourman’s last shot was only 0.2 seconds slower, and finally the Amazing ball won the Chengdu social team championship. The intensity of the live game is evident. The car owners team won the Chengdu championship by the Flames.

It is worth mentioning that this event also invited CBA star Zhu Songwei, streetball expert SOMA, and well-known bucklers Chen Junhao, Wan Xu, Xu Wencheng, and Xu Wenhao to the scene of the Geely Colorful China Steel Cannon Basketball Rising Stars Selection Tournament, which aroused cheers from fans at the scene, which undoubtedly heated up the atmosphere at the scene.

Finally, CBA star Zhu Songwei, as the selection officer, announced the MVP of the event – Serbian player SpaicFilip on the spot. Zhu Songwei said: I think talent is important, but hard work is more important. In Serbian player SpaicFilip, I saw the kind of never-admit-defeat struggle. This struggle is also the interpretation of the Battle spirit that Colorful has always passed on for young competition. This spirit of never giving up at any time is also what I have always believed in. In him, I saw myself. And SpaicFilip players will be selected as potential rising stars, and together with the rising stars of Chengdu, Kunming, Changsha and Hangzhou, they will form a new team and go to the Beijing finals.

Subsequently, the streetball expert SOMA also performed at the Chengdu station; the SOMA step of "my true biography" was selected to compete on the spot. Chen Junhao, Wan Xu, Xu Wencheng, and Xu Wenhao participated in the dunk contest, and SOMA, Zhu Songwei, and Geely representatives were the judges. The audience brought wonderful performances such as dunk, dunk, front dunk, reverse dunk, and fancy dunk. Finally, Xu Wenhao won the championship of the dunk contest. SOMA and Zhu Songwei made professional comments on the competition and provided valuable experience and suggestions to the dunkers.

Geely’s representative commented on the players: the original intention of the sportsmanship event that keeps fighting is very suitable. As a high-performance SUV built for young people, Colorful not only satisfies young people’s pursuit of performance with the strength of Chinese steel cannons, but also hopes that such a model with a battle spirit can truly inspire young people, allowing young people to battle and enjoy, just like perseverance and struggle on the field of love, competing for young people.

At the scene, in addition to exciting basketball games, spectators can also participate in swtich games, DIY painting, fun dunks, manicures, and Geely Colorful test drives in the interactive area, and participate in a weekend party in person.

As a global model created by Geely for young people, Geely Binyue has a stable structure with BMA modular architecture, 7.9S zero-hundred acceleration performance and sporty appearance, which has attracted some young people. This time, Geely Binyue further bundles "basketball" and "car". Through the creation of basketball IP, it encourages more people to participate in basketball, helps basketball fans chase their basketball dreams, and discovers more potential and possible young players to help the development of Chinese basketball culture. The next stop, Kunming Station, will be held on July 10-11. Friends who like battle may wish to look forward to it.

Text | Photographs, Ah Kun

　　Million Chinese stars, subversion and start again! Recently, Geely China Star Intelligent Dual Engine once again challenged the high difficulty, bravely picking the three major landmarks of Japan’s Tsukuba Circuit, Qiumingshan and Tomei Line, and achieved outstanding performance such as 7.92s 100 kilometers acceleration, 79.9km/h elk, and 4.3L 100 kilometers fuel consumption. It also set the fastest lap record of the first Chinese A-class sedan at Tsukuba Circuit with a lap time of 1:18.03, demonstrating high performance, strong control, and low fuel consumption. All-round hardcore strength. With 1.5TD four-cylinder hybrid special engine + the world’s leading three-speed intelligent frequency conversion technology + X · System intelligent control system and other innovative technologies, China Star Intelligent Dual Engine has broken the long-standing technical barriers of oil mixing, achieved energy-saving, performance and intelligent balanced development, with Chinese solutions and Chinese standards, leading the global oil mixing technology to continue to advance, and quickly entering the more advanced, smarter, safer and more comprehensive Chinese "Star" era.

　　As a classic "Holy Land of Brushing Circles" and F3 race base in Japan, Tsukuba Circuit has a unique design of 8 complex curves including short and compact, low-speed compound curve + high-speed curve + hairpin curve, which places extremely high requirements on the driver’s driving technology and the vehicle’s dynamic performance and control and other comprehensive mechanical qualities. Faced with such a difficult challenge, China Star Intelligent Dual Engine has no stage fright, with 7.92s 100 kilometers acceleration, 34.65m braking distance, 79.9km/h elk, 1 minute, 18 seconds and 03 laps, etc., leading the Japanese Dual Engine products of the same level in an all-round way.

　　China Star Intelligent Dual Engine’s leadership lies not only in its strong power performance, but also in the field of fuel economy. In the fuel consumption test project of the Dongming Line, after 1.5 hours and 104km of uninterrupted driving, the fuel consumption is only 4.3L/100km, and the actual fuel consumption measured by the refueling method is 4.46L/100km. The strength catches up with the same level of oil-mixed models.

　　Behind the outstanding results is the strong confidence and confidence given by the technological innovation of China Star Intelligent Dual Engine. Compared with the Japanese equivalent oil-mixed products, which are mainly fuel-saving self-priming engines + single-speed electric drives, China Star Intelligent Dual Engine is equipped with a 1.5TD direct injection turbocharged hybrid special four-cylinder engine with a thermal efficiency of up to 44.26% as standard, which can release 120kW maximum power and 255N · m maximum torque; then matched with the world’s leading 3-speed intelligent frequency conversion DHT, supports P1 + P2 dual motor drive, and can enter the full speed domain at a speed of more than 20km/h. The maximum wheel end output torque is 4920N · m, and the torque-to-mass ratio is 41N · m/kg. The maximum transmission efficiency is up to 97.5% in the world, with almost no energy loss. Low-speed electricity consumption, medium-speed fuel-saving, and high-speed power supply, China Star Intelligent Dual Engine’s strength subverts the inherent cognition of "hybrid only energy-saving, no performance" shaped by traditional oil-mixed products in the past, and provides users with a new generation of Chinese hybrid solutions and options that "balance performance and fuel-saving".

　　If the Tsukuba Circuit and the Tomei Line in Japan demonstrate the pinnacle of China Star Intelligent Dual Engine’s power performance and energy conservation, then the "holy land of running mountains" in the hearts of many racers, Akiyama Mountain, is the best test ground to show the powerful handling strength of China Star Intelligent Dual Engine. The mountain road of only 3 kilometers has steep twists and turns, with more than 30 corners, and an average of nearly 180 degrees every 100 meters. The road down the mountain is thrilling and exciting, which greatly tests the vehicle’s handling performance and the mechanical quality of the vehicle.

　　Relying on the natural good foundation given by the world-class CMA architecture, L Intelligent Engine is supported by the world’s leading wire-controlled chassis technology, McPherson front suspension, multi-link independent rear frame, ZF DP-EPS steering power system, and the longest suspension stroke design of the same level. With strong grip and excellent corner handling, it can quickly respond to the driver’s intention and accurately feed back road condition information. Whether it is entering a corner, bending, or exiting a corner, the whole vehicle body posture is very beautiful and smooth, bringing a driving texture that combines driving comfort and sports control. Especially under the inherent advantages brought by the 29000N · m/deg torsional stiffness comparable to millions of luxury cars, the dynamic roll stiffness of 3.65deg/g, and the negative camber design of the only racing car in the same class, Xingrui L Intelligent Engine still performs well in the famous five-star autumn famous mountain hairpin bend, which not only accurately locks the wheel track, ensures the accuracy and flexibility of the vehicle, but also enhances the vehicle’s cornering grip and agility, bringing excellent driving confidence and racing-like attacking and cornering experience.

　　No frequency conversion does not save energy, and no performance does not subvert. From the dynamic performance test of Tsukuba Circuit, to the 104km fuel consumption test of Dongming Line, and then to the control test of Qiumingshan, China Star Intelligent Dual Engine has fully confirmed that China Hybrid has the strong strength to subvert the hybrid pattern and redefine the new standard of global hybrid value with excellent performance and leading technical confidence.

　　It is with this kind of product confidence and strong technical confidence that has been rooted in the bones of "not trying is not better than not selling" since its birth, China Star has always insisted on creating high value, constantly breaking through and subverting along the way, running out of China’s "Star" speed, becoming the first high-end series in China’s A-class fuel vehicle market to break through 1 million sales; among them, Xingrui and Xingyue L have entered the hinterland of the A-class mainstream fuel vehicle market, and in April they ranked No. 1 in China’s fuel SUV and sedan sales, leading the new pattern of China’s fuel vehicle market.

　　The next million-dollar era has begun! China Star, China Auto, has never been afraid of head-on competition, dared to show the sword, and let the world see the confident rise and powerful power of Chinese manufacturing.

Feature: Picture Channel

Topic: The devastating earthquake in Wenchuan, Sichuan

Feature: Fighting the Earthquake: The Cutest Soldiers

　　On the 19th, Jackie Chan and young players Wang Wenjie and Liu Fengchao showcased their fists at Cannes

　　On May 19, local time in Cannes, Jackie Chan appeared in Cannes to promote the kung fu film "Wushu Youth", which he was the producer of. Although the original intention of the producer of the film was to cultivate and recommend kung fu newcomers, due to the earthquake in China, Jackie Chan also shifted the focus of the topic to focus on the disaster situation, saying that he would temporarily put aside other work at hand to concentrate on setting up a special fund for disaster relief and planning large-scale disaster relief performances.

　　Working on establishing a fund for disaster areas

　　Jackie Chan revealed that when he learned of the earthquake in the country, he was considering how to give some help to Myanmar, but he heard the news before the plan was discussed. Before coming to Cannes, Jackie Chan had been busy with disaster relief, and he would leave immediately after the event to continue the relief work.

　　"After the earthquake, every Chinese person is contributing money, but the reconstruction work after the disaster is the most important, so I won’t go anywhere now, put aside other work at hand for the time being, and focus on doing something for the disaster relief." Jackie Chan said that the disaster will not pass in a day or two, and may take up to seven or eight years to rebuild. "I am busy setting up a special fund for disaster relief, so that I can give some help to the disaster area every year. Now how to appease those children and help their spiritual health is the most important thing."

　　"We have a strong cohesion."

　　Jackie Chan had previously donated 10 million yuan to the disaster area with Emperor boss Yang Shoucheng, and he himself went to the disaster area in Sichuan. Speaking of his feelings at the time, Jackie Chan said: "My car was driven by a police car, but the cars on both sides were delivering supplies on one side, and the other was empty cars coming back. There were also many people riding bicycles to send supplies. The touching deeds of the frontline personnel made me cry dry."

　　Jackie Chan’s influence in the world film industry has attracted a large number of overseas media. He said publicly at the press conference: "Money is not a problem in China now, we have too much money. What I feel the most about this is that I see the strong cohesion of our Chinese people."

　　In addition, when asked by overseas media about some negative reports about the Beijing Olympics, Jackie Chan replied: "Many reports are untrue and there are too many misinterpretations. I love sports, I believe everyone loves sports, and the Olympic Games are not only the Olympic Games in China, but also the Olympic Games in the world."

Editor in charge: Zhang Tuoya

IT House reported on April 18th that according to the feedback from users of IT House, Xiaomi 14 Ultra mobile phone has been internally updated to support 5G-A(5.5G), the version number is 1.0.9.0.UNACNXM, and the installation package size is 527 MB.

IT House with main updates:

Add convenient satellite communication and Tiantong business entrance to enjoy the satellite experience;

Add 5G-A capabilities and experience the extreme rate of 5G (the actual state depends on the local operator’s network and business deployment);

Incorporate the April 2024 security patch to enhance system security.

The official of China Mobile has previously measured the 5G-A of Xiaomi 14 Ultra, and the downlink rate has exceeded 5Gbps, reaching 5132.34 Mbps. Xiaomi Company also expressed its congratulations to China Mobile Group for its first commercial deployment of 5G-A in the world. Xiaomi 14 Ultra will jointly introduce more new features of 5G-A with China Mobile, hoping to achieve new heights in time delay and speed.

For other vendors, OPPO Find X7 Ultra has pushed the 5.5G network upgrade package. Vivo X Fold3 series and iQOO 12 series also confirmed their support for 5.5G networks. Glory Jiang Hairong said that Magic6 has supported 5.5G networks, but there is no 5G-A logo.

　　On July 1st and September 1st this year, the State Bureau for Letters and Calls successively opened a "channel" for letters and visits on mobile phones — — The mobile phone petition platform and WeChat WeChat official account will further broaden the channels for expressing people’s demands. These new channels for letters and visits have been in operation for nearly half a year. What is the effect now?

　　What about the new channels of letters and visits such as mobile phone platform and WeChat?

　　By the end of November, there were over 60,000 registered users and 80,000 letters and visits.

　　"It’s great, you don’t have to go out and move your fingers, and the problems reflected will be solved!" Not long ago, Wang of Huai ‘an City, Jiangsu Province reported the inconvenience caused by the renovation of dangerous bridges in the village through the online petition platform. The next day, she inquired that the Jiangsu Provincial Bureau for Letters and Calls had accepted it. On the fourth day, the local government began to solve the problem.

　　On January 1, 2015, the State Bureau for Letters and Calls established and operated the National Information System for Letters and Calls, realizing the nationwide "One Netcom" with vertical connectivity to towns and streets and horizontal coverage of relevant responsible departments.

　　On this basis, on July 1st and September 1st this year, the State Bureau for Letters and Calls successively launched the mobile phone petition platform and WeChat WeChat official account, making it more convenient and efficient. The process and results of the petitions handled by the masses through the mobile phone petition platform can be inquired, tracked, supervised and evaluated. The reporter saw on the WeChat WeChat official account of the State Bureau for Letters and Calls that WeChat official account currently has three functions: information on letters and visits, guide to letters and visits and online letters and visits. By paying attention to this micro-signal, you can submit a complaint request or make suggestions in the online letters and visits channel, and you can also inquire about the handling of letters and visits and evaluate your satisfaction.

　　By the end of November, more than 60,000 users had registered through the mobile phone petition platform of the State Bureau for Letters and Calls and WeChat WeChat official account, and the number of petitions reached 80,000. At the same time, all parts of the country have followed suit. 14 provinces including Anhui, Hunan and Xinjiang have set up mobile phone letters and visits, and 21 provinces including Hebei, Inner Mongolia, Guizhou and Gansu have opened WeChat letters and visits. Online letters and visits have gradually become the main channel for mass letters and visits.

　　How to make online letters and visits efficient and transparent?

　　The process, methods and results are all open online, so that the masses can become "supervisors" and "referees" of letters and visits.

　　"This platform can see every step of the specific process, just like online shopping can see whether the seller has delivered the goods and where it has gone. It is really convenient." Bao, from Haiyang City, Shandong Province, reported the damage of the road in front of his house through online letters and visits, and received a reply on the same day.

　　On July 1 this year, the State Bureau for Letters and Calls promulgated and implemented the Measures for Simple Handling of Letters and Visits (Trial), which requires that opinions should be given within 10 working days after accepting the letters and visits that can be handled simply, so as to accept and handle the letters and visits more conveniently and quickly.

　　At the same time, according to the "Regulations on Letters and Visits" and the "Working Rules for Online Handling of Letters and Visits (Trial)" of the State Bureau for Letters and Calls, all localities have standardized the letters and visits business, so that there are rules to follow. Twenty-four provinces, including Shanxi, Jilin and Ningxia, have formulated rules for handling online letters and visits, further optimizing business processes and putting standardization requirements throughout the whole process.

　　"Relying on the national petition information system, the handling process, handling methods and handling results of petitions can be made public online, and petitioners can inquire about the handling process and results at any time, avoiding going back and forth." In addition, the State Bureau for Letters and Calls also said that it is also the focus of online letters and visits to let the masses evaluate the solution of the letters and visits, let the masses become "supervisors" and "referees" in the work of letters and visits, and actively guide the petitioners to evaluate their satisfaction. At present, the State Bureau for Letters and Calls has revised and improved the satisfaction evaluation method, and promoted all localities to improve the participation rate of the masses and the satisfaction rate of the masses.

　　How do large and small systems break through the "barriers"?

　　Integrate the scattered "small windows" of letters and visits, and "one netcom" allows the masses to travel less and benefit more.

　　At present, the State Bureau for Letters and Calls has realized the interconnection with 31 provinces (autonomous regions and municipalities) and the provincial, municipal and county-level letters and visits working institutions of Xinjiang Production and Construction Corps, more than 80,000 functional departments and towns (streets), and 33 central and state organs and ministries.

　　At the same time, all localities are also stepping up efforts to promote the integration of resources on the online petition platform at the same level. Tianjin, Zhejiang and other places have connected the leadership mailbox with the petition information system, and integrated the scattered online petition "small windows" into an online complaint hall to reduce repeated complaints from the masses and repeated referrals from departments, thus realizing "one netcom". Jiangxi, Shandong, Hubei and other places have established self-service facilities for online letters and visits in counties and townships to better facilitate the masses. From January to November this year, the number of online letters and visits nationwide was 971,000, up 102% year-on-year, which effectively reduced the cost of letters and visits by the masses and realized that the masses traveled less and benefited more.

　　The relevant person in charge of the State Bureau of Letters and Calls said that in recent years, various localities have made great efforts to solve problems, and a number of letters and visits have been effectively resolved. However, in some places, problems were not handled in time and were not solved in place, which led to repeated online complaints; In some places, the previous "handling opinions" are used as the handling results of the backlog report, but the problem of letters and visits has not been substantially solved, and there is a problem of "doing without finishing", so it is necessary to continue to intensify efforts to resolve it.

　　According to the introduction of the State Bureau for Letters and Calls, after continuous adaptation and improvement, the national information system for letters and calls has been running smoothly on the whole. Next, efforts should be made to improve the application and optimize the functions. At present, the coverage of the national petition information system has basically achieved the "vertical to the end" of the five-level petition work institutions at the national, provincial, municipal, county and township (street) levels, but there is still a problem of incomplete coverage of functional departments in most places horizontally. The next step will focus on promoting the full coverage of the application of the petition information system by functional departments.