On February 15th, 2023, Spring Festival travel rush officially closed. In 40 days, railways, highways, waterways and civil aviation have sent more than 1.5 billion passengers. People who packed their bags, with the blessings of their loved ones, rushed to the far and wide again, interwoven into a warm picture of China.

　　The best time on earth is early spring. As the first Spring Festival travel rush after the epidemic prevention and control entered a new stage, people have realized their dream of reunion, and are also moving forward for the new goal and new atmosphere of the new year.

　　The passenger flow is rising and the traffic is smooth, and the mobile China is full of vitality.

　　On February 14th, 2023, Spring Festival travel rush is drawing to a close, but Asia’s largest railway passenger transport hub — — Beijing Fengtai Station is still busy. Travellers from the south to the north, dragging their luggage and carrying their hometown specialties, set foot on their way back to work and school under the guidance of the station staff.

　　"This year, the passenger flow in Spring Festival travel rush has increased significantly, and our work has become more busy. However, seeing the normal flow of people in cities and stations, passengers’ faces are filled with happy smiles, and all our service guarantees are worthwhile. " Ling Chengcheng, chief of the comprehensive support section of the Beijing Fengtai Station District Management Office of the Beijing Key Station District Management Committee, said.

　　The EMU train stops at the storage line of Wuhan EMU (photo taken on January 7, photo of unmanned aerial vehicle splicing). Xinhua News Agency reporter Wu Zhizun photo

　　Compared with Spring Festival travel rush in previous years, during Spring Festival travel rush in 2023, the passenger flow of railway Spring Festival travel rush continued to rise. According to the data, since February, the national railways have sent more than 9 million passengers per day and operated more than 9,000 passenger trains, basically recovering to 90% of the same period in Spring Festival travel rush in 2019.

　　As a popular means of transportation, railway bears the responsibility of ensuring the long-distance and large-scale flow of population. As the first choice for short-distance travel, road travel is also favored by the public in this year’s Spring Festival travel rush.

　　"From Spring Festival travel rush to the fifteenth day of the first month, the service area appears almost every day ‘ Super busy ’ State, the passenger traffic in the 360 service areas under our jurisdiction increased by 2 to 4 times year-on-year, and the overall turnover also increased significantly compared with the same period of last year. " The relevant person in charge of Guangdong Tongyi Expressway Service Area Co., Ltd. said.

　　According to the data from Didi Chuxing, from January 7 to February 14, Didi’s car and taxi order calls continued to grow, and they have recovered to more than 90% in the same period in 2019. Among them, Beijing, Shanghai and Guangdong recovered over 90%, and Shenzhen recovered nearly 90%. In addition, the demand for taxis in second-and third-tier cities such as Dalian, Yancheng, Nanchang and Mianyang has also increased significantly.

　　Passengers lined up at the entrance of Shenzhen North Railway Station (photo taken on January 18). Xinhua News Agency reporter Mao Siqian photo

　　The continuous growth of passenger flow and the orderly road in the busy schedule highlight the vitality and vigor of the mobile China — —

　　After the Lantern Festival, in the Shanghai Railway Station of Shanghai Metro Line 1, people carrying big bags and small bags passed quickly and orderly under the guidance of staff and police. The bustling scene made many people feel that "the busy international city is back";

　　During the Spring Festival, Sanya Air Traffic Control Station reached a new high, with a total of 3,024 flights in seven days, an increase of 5.8% over the same period in 2019. "Now the apron is full of planes, and the number of wide-body aircraft and business jets has increased significantly";

　　In the second half of Spring Festival travel rush, the number of passengers carried by passenger ships under the jurisdiction of Shandong Weihai Maritime Safety Administration increased significantly, and the daily average number of passengers carried remained at around 20,000, an increase of 192% compared with the first half of the year & hellip; …

　　"Overall, the operation of railways, highways, waterways and civil aviation in the country has remained stable, with adequate capacity allocation, orderly services and strong emergency support, and the national security situation is generally stable." Zhou Wei, deputy director of the Emergency Office of the Ministry of Transport, said.

　　Excellent service and further upgrade will help Spring Festival travel rush to be safe and smooth.

　　When Aunt Tang, who had never flown alone, entered the T3 terminal of Shenzhen Airport, Peng Yihan, an airport worker who had been waiting for a long time, was greeted: "Aunt Tang, your son applied through the airport hotline ‘ Whole-process assistance for elderly travelers ’ Love service, I will accompany you to the boarding gate. " Accompanied by the staff all the way, Aunt Tang successfully boarded the flight back to her hometown in Xi ‘an.

　　In Spring Festival travel rush this year, "warm heart service" became one of the key words.

　　A number of airports and airlines have upgraded the "first-time passenger service" in an all-round way, providing full-process services such as check-in, security check-in and waiting for flights for first-time passengers; 12306 Continue to improve the transfer plan, train operation and information related to "food, accommodation, travel and purchase" to make it more convenient for passengers to obtain information; The service of "Smooth Train" has covered more than 3,400 emus of 18 railway bureau group companies. Passengers can check the information of the train’s delay and running position by scanning the "Smooth Train" code on the armrest of the seat … …

　　On January 30th, 531 migrant workers from Dingxi, Gansu Province took the G1904 train from Dingxi North Station and went to Fuzhou, Fujian Province, more than 2,000 kilometers away, to start a new year’s migrant journey.

　　Under the guidance of the staff of Dingxi North Station in Gansu Province, migrant workers are preparing to take the free high-speed train for returning to work to Fuzhou, Fujian Province (photo taken on January 30). Xinhua News Agency (photo by Wang Guanghui)

　　"From Dingxi to Fuzhou, the ordinary train takes more than 30 hours, and this high-speed train only takes more than 13 hours." Shi Xuexia, who works in an automobile motor factory in Fuzhou, said that when she arrived in Fuzhou, there was a special car in the factory to pick her up for work.

　　China Railway Chengdu Bureau Group Co., Ltd. took the initiative to find out the number of trips, and launched a total of 24 "point-to-point, one-stop" direct return trains, with a transportation capacity of 14,000 passengers; Yunnan has organized more than 1,460 "point-to-point" transportation services, such as "special buses for workers, special trains and charter flights", which have helped 49,300 rural laborers realize the transfer of employment … … Towards a struggle and a better life, cars, high-speed trains and planes continue to travel.

　　Cyclists returning home rest at Spring Festival travel rush Qingwen Station at the east exit of Wuzhou City, Guangxi (photo taken on January 7). Xinhua News Agency reporter Huang Xiaobang photo

　　Security is a constant theme in Spring Festival travel rush.

　　In Hami, Xinjiang, in the extremely cold weather, the law enforcement officers of the Barkun Law Enforcement Brigade of Xinjiang Transportation Comprehensive Administrative Law Enforcement Bureau waded knee-deep in snow to find trapped vehicles, and guided the trapped people to rest in the nearby service area one by one, and provided meals and accommodation; At the same time, snow removal and deicing equipment such as snow removal vehicle, sweeper and snow melting agent distributor are used to ensure smooth roads.

　　"During the period of Spring Festival travel rush, tens of thousands of cars went out of Xinjiang through the G7 Jingxin Expressway every day. What we are most worried about is the windy and snowy weather, which is likely to cause vehicle failures and frostbite." Tao Zhiliang, secretary of the Party branch of the Barkun Law Enforcement Brigade, said that the weather is getting warmer now, and the brigade will make preparations for preventing avalanches and flood control in spring.

　　The crew of China Southern Airlines carried out deicing and anti-icing operations at Longdongbao International Airport in Guiyang (photo taken on January 17). Xinhua News Agency reporter Yang Wenbin photo

　　Ensure the prosperity of materials and freight, and run forward in the new year.

　　Zhejiang, Yiwu West Railway Station, trucks enter and exit in an orderly manner, and gantry cranes load containers on the "Yixin Europe" Central European train. The "steel camel team" full of goods is ready to go, injecting strong vitality into China’s foreign trade and economic cooperation.

　　Statistics show that in January this year, "Yixin Europe" China-Europe Yiwu platform operated 240 trains and sent 20,140 TEUs, with a year-on-year increase of 172.1%.

　　“‘ Yixin Europe ’ The shipment volume of the China-Europe Yiwu platform has grown steadily, reflecting the strong resilience and great potential of China’s economy. " Bei Xudong, deputy director of Yiwu Municipal Market Development Committee, said that during Spring Festival travel rush, railways, ports and other relevant departments made scientific overall plans and coordinated in advance according to the transportation demand and supply organization of foreign trade enterprises to ensure the smooth running of trains during Spring Festival travel rush.

　　The speeding trains reflect the steady economic recovery of China; The smooth road network weaves the people’s livelihood and well-being of all households in China.

　　A Central European train loaded containers at Dulaying Station of Guiyang International Land Port (photo taken on February 9, photo of drone). Xinhua News Agency reporter Liu Xushe

　　As dawn dawned, Master Gui, a truck driver in Shenzhen, came to the warehouse area to count the goods to be sent out that day with the store. "I am really happy to see that the merchants are busy!" Master Gui said that in the past two weeks, the merchants in the market have been busy, and the passenger flow has returned to 70% to 80% of the normal level before the epidemic.

　　According to the platform data, the freight market in Shenzhen opened higher after the Spring Festival holiday. From January 31 to February 7, the freight order volume in Shenzhen increased by 117% compared with the same period of last year. On average, more than 6,000 drivers run on the road every day to take orders actively.

　　Spring is not a mistake, and autumn is not. North and south of the river, farmland is busy.

　　On the outskirts of Kunming, Yunnan Province, Taohuacun Railway Station, 6 forklifts are working continuously. Within one hour, the staff loaded all 360 tons of chemical fertilizer into the carriage. Soon, these fertilizers will be transported to Shandong, Hebei and other places to provide nutrients for crop growth.

　　In view of the obvious increase in the transportation demand of spring ploughing production materials, several railway stations in Kunming have strengthened communication and coordination with neighboring fertilizer production enterprises, helped enterprises to "tailor-made" fertilizer transportation plans, and implemented the "four priorities" service of giving priority to planning, giving priority to air distribution, giving priority to loading and giving priority to hanging.

　　Workers carry out transportation operations on the production line of Tianan Chemical Phosphate Fertilizer Manufacturing Center of Yuntianhua Group in Anning City, Kunming, Yunnan Province (photo taken on February 8). Xinhua News Agency reporter Jiang Wenyao photo

　　According to statistics, China Railway Kunming Bureau Group Co., Ltd. has transported more than 15,000 vehicles and 919,000 tons of spring ploughing materials in 2023, with a year-on-year increase of 16.6%. The cars passing through the mountains and tunnels are carrying the hope of a bumper harvest and reaching countless distant places.

　　After 40 days and nights, Spring Festival travel rush came to an end and saw beautiful spring scenery. Spring Festival travel rush is the starting point for the revival of all industries. People are full of energy, confident and calm in the season full of hope, and strive for a brighter new year.

　　Text reporters: Ye Haoming, Ruta, Wei Hongyi, Fan Xi.

　　Poster design: Excellence

　　Fans seized the subway billboard to celebrate the idol’s birthday. After the idol announced his love affair, fans ran away and cried, and even fans blocked the star’s door for several months. The star had no choice but to send Weibo to vomit … … More and more cases of crazy idolize make people realize the importance of rational idolize while being shocked.

　　Last week, a survey of 2009 people was conducted by the Social Investigation Center of China Youth Newspaper, and it was found that 80.6% of the respondents were surrounded by people who were crazy about idolize. 55.5% of the respondents believe that the biggest harm of crazy idolize is wasting a lot of time, and 52.2% of the respondents believe that rational idolize can bring positive energy to life.

　　Among the respondents, 1.4% were born after 00, 26.6% after 90, 48.6% after 80, 16.6% after 70, 4.6% after 60 and 1.6% after 50.

　　80.6% of the respondents were surrounded by crazy idolize people.

　　The elder sister of Qiu Rui (pseudonym), a senior student in a university in Beijing, is a fan of an entertainer. When the idol openly fell in love, "she cried in the room all afternoon and bought tens of thousands of cosmetics online on impulse".

　　In the survey, 80.6% of the respondents said that they were surrounded by crazy idolize people, and 12.9% of them were surrounded by many such people.

　　I will watch the movie made by my idol at the first time and buy his album and some peripheral products. For Chen Xiaoying, an employee of an Internet company, idolize means "always willing to support idols".

　　Chen Luxin, a graduate student in Beijing, is also a fan of an entertainment star. She introduced that joining a fan group is a "key step" in the process of idolize. If you can achieve a higher level in the fan group, you can even get the opportunity to chat and eat with idols.

　　Among various forms of idolize, watching variety shows, movies and TV series in which idols participate (61.2%) is the most reasonable behavior of idolize. Other behaviors are: attending concerts, meetings and other performances of idols (55.6%); Buy albums, photos and books of idols (53.8%); Pay close attention to idols on social networking sites (38.4%); Attend fan parties (22.2%); Join the fan support group (16.8%); Pick up the plane for idols (11.3%); Giving idols high-priced gifts (9.2%); Waiting at idol companies, shooting studios and other workplaces (8.6%); Travel time is consistent with idols (6.8%); Standing on the opposite side with fans of other stars (5.4%).

　　55.5% of the respondents believe that the biggest harm of crazy idolize is wasting a lot of time.

　　Chen Xiaoying thinks that some people who lack goals in life will take a star as their goal, and they are crazy about idolize.

　　Chen Luxin has been in idolize for three years. At first, she didn’t quite understand many idolize behaviors. "But after a deep understanding, I found that idol experiences and songs can give me a lot of strength, and she will gradually become dependent."

　　So, what are the reasons for the crazy idolize phenomenon? 53.1% of the interviewees think it is normal idolatry in adolescence, 48.7% think it is due to lack of emotional sustenance, 44.4% think it is due to lack of clear goals in life, and others are: out of vanity and comparison (40.4%), over-fantasizing about their close relationship with stars (30.6%) and making themselves unique through idolize (24.7).

　　"idolize should be measured. We will also resist the crazy containment and sneak shots of idols. " Chen Luxin said.

　　After experiencing the emotional breakdown of her sister idolize, Qiu Rui realized that "you can’t concentrate all your energy on idols, otherwise you will get hurt too easily". Chen Luxin believes that idolize can bring positive energy as long as it keeps a healthy mind.

　　According to the data, wasting a lot of time (55.5%), bringing economic pressure to themselves and their families (53.2%) and neglecting relatives and friends around them (43.7%) are the three major injuries that respondents think crazy idolize brings. Others include: delaying one’s future (35.8%); Interfere with the normal life of stars and infringe on their privacy (32.8%); Many things cannot be evaluated objectively and rationally (30.7%); Emotion is easy to fluctuate and more vulnerable than others (30.5%); Idolize suffered psychological trauma (26.6%) and was used and cheated by criminals because of idolize (18.7%).

　　On the evaluation of idolize’s behavior, 52.2% of the respondents think that rational idolize can bring positive energy to life, 38.9% of the respondents think that everyone has the freedom to choose his idol, and 26.8% of the respondents think that idolize’s behavior itself is understandable. In addition, 47.1% of the respondents feel that idolize should not hurt the feelings of relatives and friends around him; 41.0% of the respondents feel that crazy idolize will affect their lives and those of others and should be avoided; 22.7% of the interviewees admitted that idolize was impetuous and over-entertained.

　　43.0% of the respondents believe that fans should be in idolize within their own financial ability.

　　"My roommate in college was ‘ Idolize clan ’ She kept introducing me to the news of her idol every day. " Chen Xiaoying said frankly, "After a long time, I will feel a little bored."

　　What influence does it have on you to have idolize around you? The data shows that 34.6% of the respondents said that if they like the same idol, they can make their relationship with their friends closer. Others include: making yourself curious about a star (28.0%); Being able to meet different people makes life more diverse (24.2%); On the contrary, I feel a little disgusted with the star chased by people around me (23.8%); The other party constantly persuaded themselves to join the "fan group" (21.0%); Also began to prepare to join the idolize team (20.8%); I learned a lot of "rice circle knowledge" and expanded my knowledge. In addition, 19.6% of the respondents said that it had no impact.

　　Chen Luxin believes that rational idolize is very important. "Some fans launched a war of abuse on the Internet without a word, which seems to be defending idols, which actually caused a worse impact."

　　How to be rational, idolize? 43.0% of the respondents suggested idolize within their own financial capacity, 46.1% felt that others should not be forced to like their idols, and 38.3% felt that others should be allowed to comment on idols. Others include: leaving enough private space and privacy for idols (39.0%); Do not act excessively when seeing idols (32.6%); Do not fight "war of words" on social networking sites (32.6%); Dig out the places worth learning from idols (30.5%); Insist on caring for relatives and friends around you (26.0%); Except idolize, they have their own lives and plans (29.2%) and their own careers and jobs that they really love (23.6%).

Original Cell Press CellPress cell science

life sciences

Life science

Fibroblasts are diverse interstitial cells, which create signal niches by producing complex extracellular matrix and biophysical and biochemical clues, and participate in tissue balance and diseases. Fibroblasts have diverse lineages and a wide range of uses, but our understanding of these cells, which fill a considerable part of the human body, is still not comprehensive. Next, let’s understand the mysterious and fascinating fibroblasts from four aspects and embark on a human journey across time and space.

Definition of fibroblast

The term "fibroblast" refers to the following kinds of cells: (1) cells that secrete many macromolecules with the same structure and signal as the extracellular space of tissues; (2) Adopting the phenotype of myofibroblasts that contract instantaneously when dealing with tissue injury; (3) signal niche cells as resident stem cells; (4) As the progenitor cells of specialized differentiated interstitial cells, they are sometimes called mesenchymal stem cells (Lemos and Duffield, 2018; Pittenger et al. , 1999, 2019）。

Fibroblasts create and maintain anatomically diverse connective tissue rich in extracellular matrix (ECM) to support a wide range of basic organ functions, such as resisting blunt and sharp skin injuries, stretching and elastic retraction in the organ range of lung, etc. In addition to producing connective tissue, fibroblasts serve as the progenitor cells of specialized interstitial cell types during embryonic development, adult homeostasis, injury, repair and remodeling, such as osteoblasts forming bones or fat cells filled with lipids.

The origin and development of fibroblasts

In 1858, German pathologist Rudolf Virchow first described fibroblasts as a unique cell type, which he called "Spindelzellen des Bindegewebes"-"Spindle cells of connective tissue" (Virchow, 1858；; Fig. 2A). Ernst Ziegler first put forward the term "fibroblast" to describe cells that produce new connective tissue after healing (Ziegler, 1895；; Fig. 2B), this observation was replicated by Santiago Ramón y Cajal, who observed that "célula fusiforme" or "fibro-células" are important producers of granulation tissue in skin wound healing and scar (Cajal, 1986；; Fig. 2C). The appearance of in vitro technology developed in the 1900 s promoted the research of fibroblasts. These methods allow primary fibroblasts from embryonic chicken heart explants to be cultured, and these cells can easily propagate before other cell types after passage (Burrows and Neymann, 1917; Carrel, 1912; Ebeling, 1913; Hogue, 1919； Fig. 2D). More than 50 years later, 3T3 fibroblast cell line from mouse embryo was established (Todaro and Green, 1963; Todaro and others,1964) further promoted our understanding of the biological and genealogical potential of fibroblasts. These findings include the identification of fibroblast growth factor (FGFS) (Gospodarovicz, 1974); Multi-line differentiation of cultured fibroblasts into bone, cartilage and fat cells (Junker et al., 2010); And the key role of fibroblasts in the production, remodeling and contraction of ECM.

Although there are a lot of studies on fibroblasts in vitro, the in vivo correlation of these cells is still unclear, and the real characteristics of fibroblasts and their pedigree potential in the in vivo primary environment have only recently been deeply explored. New evidence shows that fibroblasts have promoted major changes in the tumor-related environment, which has been widely reviewed elsewhere (Sahai et al., 2020).

Organ specificity of fibroblasts

The existence of tissue-specific fibroblast function and lineage can support the development, homeostasis and repair needs of specific organs. During embryonic development, multiple cell lines coalesce to form fibroblasts, which are filled with organs from all three somatic germ layers, such as skin and breast derived from ectoderm, skeletal muscle or myocardium derived from mesoderm, and lungs derived from endoderm. When fibroblasts proliferate in specific organs, they will produce unique microstructure, biophysical and biochemical components of connective tissue.

In organs rich in epithelial cells (for example, skin and lungs), fibroblasts in the skin produce a mechanically elastic, viscous and elastic structural foundation, which supports the epithelial cells of the outward layered epidermis and its many appendages, mainly hair follicles and sweat glands. Fibroblasts and other mesenchymal cell lines in the skin have established three anatomically different layers: papillary dermis, reticular dermis and dermal white adipose tissue (dWAT) (Figure 5A). Skin epithelial cells are derived from ectoderm, which has a unique level of connectivetissue. In contrast, lung epithelium originated from endoderm, forming a highly branched tree and eventually forming an inflatable sac called alveoli. The gas exchange function of lung depends on the close physical connection between alveolar epithelium and extensive capillary network, and on the repeated and rapid expansion and contraction ability of lung. These functions require the reticular ECM of the lung, which has the best viscoelasticity, but is strong enough to withstand the change of air pressure and prevent alveolar rupture and potentially fatal air pressure trauma. With the maturity of the lung, the lung mesenchymal progenitor cells assume different spatial positions and functions, including smooth muscle cells around bronchi and blood vessels, pericytes, numerous interstitial fibroblasts, adipocytes supporting lung cells and mesothelial cells of visceral pleura (Peng et al., 2013; Fig. 5B).

In interstitial organs (such as skeletal muscle and heart), unlike skin and lung, skeletal muscle has no epithelial structure, but is composed of large, highly differentiated and multinucleated muscle fibers arranged in parallel, and its main function is to generate strength through contraction. The connective tissue in muscle has a complex layered tissue. Its innermost layer is called endocardium, which surrounds a single muscle fiber and contains a special basement membrane rich in laminin and collagen IV. Laminin acts through its transmembrane receptor, helping the mechanical force to be transmitted from the intracellular contraction device to the inner muscle layer rich in collagen I and III (Chapman et al., 2016). Muscle fiber group is called bundle, surrounded by perimuscular layer, which forms a continuum with tendon, and is rich in so-called perimuscular layer "cable", that is, thick connective tissue bundle mainly composed of closely arranged type I and type III collagen III fibers. Finally, the whole muscle is wrapped by the connective tissue layer of the adventitia (Chapman et al., 2016). Myocardium is an anatomically and physiologically complex contractile organ. Its main cell group, cardiomyocytes, are connected with each other, and an electrically coupled tissue is formed through the sandwich disc that constitutes its middle layer, which is called myocardium. The heart is also rich in fibroblasts, which produce and reshape a powerful ECM network, which is very important for conductivity and heartbeat rhythm. In addition to myocardium, fibroblasts also exist in the outermost epicardium, which contains specialized adipose tissue, and the innermost endocardium, with a layer of endothelial cells at its edge.Unlike most other organs’ fibroblasts, which originated from mesenchymal progenitor cells through gradual standardization, most cardiac fibroblasts are formed through EMT, and fibroblasts located in interventricular septum and right ventricle are products of EndMT (Gittenberger-de Groot et al., 1998; Fig. 5D).

Application of fibroblasts in diseases

At present, the approved anti-fibrosis therapy is aimed at the activation of fibroblasts in established diseases and cannot restore the structure and function of diseased tissues. Therefore, developing strategies to promote the repair of damaged tissues will greatly promote the development of this field.

Although the plasticity of fibroblasts may be problematic in the context of fibrotic diseases, it also provides opportunities for regenerative intervention. Recently, this understanding has promoted the development of in-situ reprogramming into fibroblasts by molecular strategy to restore tissue anatomy and function (including direct reprogramming). In skin wounds, the innate ability of fibroblasts to support hair follicle regeneration can be induced by transcription reprogramming.

Examples have proved that the principle of therapeutic reprogramming of fibroblasts in vivo can be realized in liver and heart, such as transferring transcription factors such as Foxa3, Gata4, Hnf1a and Hnf4a to myofibroblasts in liver through viruses, reprogramming them into hepatocyte-like cells, and reducing the signs of liver fibrosis in mouse models (Rezvani et al., 2016; Song et al., 2016). The above examples clearly emphasize the therapeutic potential of reprogramming tissue-resident fibroblasts directly into "working" cells, and suggest it as a new scar replacement strategy. However, there are still several important problems to be solved, including the efficiency of reprogramming factor delivery using non-integrated vectors and high fibroblast specificity (if not exclusiveness), in order to transform this attractive method into safe clinical application.

Conclusion and prospect

In the past decades, our understanding of fibroblast biology under different organs and conditions has made remarkable progress. New methods and techniques have made this field develop from phenotypic study of cultured cells more than a century ago to complex genetic and functional observation in vivo. These advances reveal that fibroblasts from different organs (such as skin, lung, heart and skeletal muscle) have unexpected similarities and unique characteristics, so they are currently used to treat human diseases.

While great progress has been made, many problems and opportunities still exist. For example, the ongoing efforts to adopt single-cell omics and space genomics technologies will provide key insights into the heterogeneity of fibroblasts within and between tissues, and their ability to assume multiple functional States for physiological or disease triggers. With our understanding of the basic function of fibroblasts far beyond the scope of ECM synthesis, in-situ regulation of fibroblasts can bring new therapeutic possibilities for a wide range of diseases characterized by aging, pathological remodeling and tissue fibrosis. New research fields, including cross-regulation between wound fibroblasts, immune cells and peripheral nervous system, are very important for understanding how to restore tissues to their pre-injury state. Finally, effective clinical transformation will require rigorous verification in local human tissues and human-like models, such as organotypic cultures, xenotransplantation and organs derived from pluripotent cells. These advances will make it possible to prevent, treat and even reverse fibrosis through proper and controlled repair.

Related paper information

The original paper was published in Cell, a periodical of CellPress Cell Press. Click "Read the original" to view the paper.

▌ Paper title:

Fibroblasts: Origins, definitions, and functions in health and disease

▌ Website of the paper:

https://www.cell.com/cell/fulltext/S0092-8674(21)00792-3

▌DOI：

https://doi.org/10.1016/j.cell.2021.06.024

Read the original text

　　Cctv news: On June 14th, the State Council held a press conference on the operation of the national economy in May. Fu Linghui, spokesperson of the National Bureau of Statistics, introduced the operation of the national economy in May 2019 and answered questions from reporters. It is reported that this is also the first time that Director Fu has met with reporters.

　　Fu Linghui introduced at the meeting that in May, the national economy continued to operate in a reasonable range, continuing the overall stable, steady and progressive development trend.

　　First, the service industry continued to grow, and the emerging service industry developed in depth.

　　In May, the national service industry production index increased by 7.0% year-on-year, and the growth rate dropped by 0.4 percentage points from the previous month. From January to May, the national service industry production index increased by 7.3% year-on-year, 0.1 percentage point lower than that in January-April, and the same as that in January-February. In May, information transmission, software and information technology services, leasing and business services increased by 22.2% and 8.4% respectively year-on-year, and the growth rate was faster than the national service industry production index by 15.2 and 1.4 percentage points respectively. The business activity index of service industry was 53.5%, up 0.2 percentage points from last month, and remained above threshold. The business activity indexes of railway transportation, air transportation, postal service, accommodation, telecommunications, broadcasting, television and satellite transmission services, and Internet software and information technology services are all in the higher boom zone of more than 60.0%. The expected index of service business activities is 59.5%, which is at a high level.

　　Second, industrial production has increased steadily, and high-tech manufacturing has grown rapidly.

　　In May, the added value of industrial enterprises above designated size increased by 5.0% year-on-year, and the growth rate dropped by 0.4 percentage points from last month. From January to May, the added value of industrial enterprises above designated size increased by 6.0% year-on-year, and the growth rate dropped by 0.2 percentage points from January to April. In terms of economic types, in May, the added value of state-owned holding enterprises increased by 3.7% year-on-year, joint-stock enterprises increased by 6.6%, and foreign-invested enterprises from Hong Kong, Macao and Taiwan decreased by 0.3%. In terms of three categories, the added value of mining industry increased by 3.9% year-on-year, manufacturing industry increased by 5.0%, and electricity, heat, gas and water production and supply industries increased by 5.9%. The added value of high-tech manufacturing increased by 9.4% year-on-year, 4.4 percentage points faster than that of industries above designated size; The output of new energy vehicles and solar cells increased by 16.0% and 9.9% respectively. In May, the manufacturing purchasing managers index (PMI) sub-index, the production index and supplier delivery time index were 51.7% and 50.9%, respectively, both above the critical point.

　　Third, the growth rate of market sales accelerated, and the proportion of online retail continued to increase.

　　In May, the total retail sales of social consumer goods was 3,295.6 billion yuan, up 8.6% year-on-year, and the growth rate was 1.4 percentage points higher than that of last month. According to the location of business units, the retail sales of urban consumer goods was 2,830.4 billion yuan, an increase of 8.5% year-on-year; The retail sales of rural consumer goods reached 465.2 billion yuan, up by 9.0%. According to consumption types, catering revenue was 363.1 billion yuan, an increase of 9.4%; Retail sales of commodities reached 2,932.4 billion yuan, an increase of 8.5%. The retail sales of cosmetics, beverages, daily necessities, Chinese and western medicines above designated size increased by 16.7%, 12.7%, 11.4% and 11.2% respectively, which was 8.1, 4.1, 2.8 and 2.6 percentage points faster than the total retail sales of social consumer goods respectively.

　　From January to May, the total retail sales of social consumer goods reached 16,133.2 billion yuan, up 8.1% year-on-year, and the growth rate was 0.1 percentage point faster than that in January-April. The national online retail sales reached 3,864.1 billion yuan, up 17.8% year-on-year, and the growth rate was the same as that in January-April, 2.5 percentage points faster than that in January-March. Among them, the online retail sales of physical goods was 3,041.5 billion yuan, up 21.7%, accounting for 18.9% of the total retail sales of social consumer goods, up 0.3 and 0.7 percentage points respectively from January to April and January to March, and up 2.3 percentage points from the same period of last year.

　　4. Investment maintained growth, and investment in high-tech industries grew well.

　　From January to May, the national investment in fixed assets (excluding farmers) was 21,755.5 billion yuan, up 5.6% year-on-year, and the growth rate was 0.5 percentage points lower than that in January-April. Among them, private investment was 13,082.3 billion yuan, an increase of 5.3%. In terms of industries, investment in the primary industry decreased by 2.3% year-on-year; Investment in the secondary industry increased by 3.2%, of which investment in manufacturing industry increased by 2.7%, 0.2 percentage points faster than that in January-April; Investment in the tertiary industry increased by 7.1%, of which infrastructure investment increased by 4.0%. Investment in high-tech industries grew rapidly. Investment in high-tech manufacturing and high-tech service industries increased by 10.2% and 15.6% respectively year-on-year, and the growth rate was 4.6 and 10.0 percentage points faster than the total investment. From January to May, the national investment in real estate development was 4,607.5 billion yuan, up by 11.2% year-on-year. The growth rate dropped by 0.7 percentage points from January to April and accelerated by 1.7 percentage points over the previous year. The national commercial housing sales area was 555.18 million square meters, down 1.6% year-on-year; The national sales of commercial housing reached 5,177.3 billion yuan, up 6.1% year-on-year.

　　V. The employment situation is generally stable, and the survey unemployment rate is flat.

　　From January to May, 5.97 million new jobs were created in cities and towns nationwide, accounting for 54% of the annual plan. In May, the national urban survey unemployment rate was 5.0%, the same as last month. Among them, the survey unemployment rate of the population aged 25-59 was 4.5%, which was 0.2 percentage points lower than that of the previous month and dropped for three consecutive months. The survey unemployment rate in 31 big cities and towns was 5.0%, which was the same as last month. The average weekly working hours of employees in enterprises nationwide were 46.3 hours, an increase of 0.5 hours year-on-year.

　　Six, the consumer price rose moderately, and the price increase of industrial producers fell back.

　　In May, the national consumer price rose by 2.7% year-on-year, an increase of 0.2 percentage points over the previous month, which was the same as the previous month. By category, the prices of food, tobacco and alcohol rose by 5.8%, clothing by 1.7%, housing by 1.8%, daily necessities and services by 1.0%, transportation and communication by 0.9%, education, culture and entertainment by 2.6%, medical care by 2.5% and other goods and services by 2.1%. After deducting food and energy prices, the core CPI rose by 1.6%, down 0.1 percentage point from last month. From January to May, the national consumer price rose by 2.2% year-on-year.

　　In May, the ex-factory price of industrial producers nationwide rose by 0.6% year-on-year, down by 0.3 percentage points from the previous month and up by 0.2% from the previous month. The purchase price of industrial producers nationwide rose by 0.2% year-on-year, which was flat from the previous month. From January to May, the ex-factory price and the purchase price of national industrial producers rose by 0.4% and 0.2% respectively.

　　7. Exports maintained rapid growth and the trade structure was constantly optimized.

　　In May, the total import and export volume was 2,592.5 billion yuan, a year-on-year increase of 2.9%. Among them, exports were 1,435.8 billion yuan, an increase of 7.7%; Imports reached 1,156.7 billion yuan, down 2.5%. Import and export balance, trade surplus of 279.1 billion yuan, an increase of 89.8%. From January to May, the total import and export volume was 12,104.1 billion yuan, a year-on-year increase of 4.1%. Among them, exports were 6,498.7 billion yuan, an increase of 6.1%; Imports reached 5,605.3 billion yuan, up by 1.8%. The structure of trade mode was further optimized. From January to May, the import and export of general trade increased by 6.1% year-on-year, accounting for 59.9% of the total import and export, up by 1.1 percentage points over the same period of last year. The import and export of private enterprises increased by 11.1%, accounting for 41.4% of the total import and export, an increase of 2.6 percentage points over the same period of last year. From January to May, industrial enterprises above designated size achieved a export delivery value of 4,763.4 billion yuan, a year-on-year increase of 4.4%.

　　8. Deepening structural reform on the supply side and improving the efficiency of service enterprises.

　　At the end of April, the asset-liability ratio of industrial enterprises above designated size was 56.8%, down 0.5 percentage points year-on-year. Commercial housing inventory decreased. At the end of May, the area of commercial housing for sale in China was 509.28 million square meters, down 9.1% year-on-year, down 4.53 million square meters from the end of April. The unit cost of enterprises is lower than that at the beginning of the year. Investment in the short-board sector has increased. From January to May, the investment in ecological protection, environmental management and education increased by 41.5% and 15.4% respectively, which was 35.9 and 9.8 percentage points faster than the total investment.

　　From January to April, the operating income of service enterprises above designated size increased by 9.8% year-on-year, among which the strategic emerging service industry, science and technology service industry and high-tech service industry increased by 12.1%, 11.9% and 11.9% respectively, which were 2.3, 2.1 and 2.1 percentage points faster than all service industries above designated size. The operating profit of service enterprises above designated size increased by 9.2% year-on-year, and the growth rate was 0.8 percentage points higher than that of the same period of last year. From January to April, the operating income of industrial enterprises above designated size increased by 5.1% year-on-year, and the total profit decreased by 3.4% year-on-year. From January to April, the profit rate of operating income of industrial enterprises above designated size was 5.52%, 0.21 percentage points higher than that in January-March.

　　Fu Linghui said that, on the whole, the national economy in May was generally stable, steady and progressing, and continued to operate in a reasonable range. At present, the external environment is unstable and uncertain, the problem of insufficient domestic development imbalance is still outstanding, and the foundation of sustained and healthy economic development needs to be consolidated.

On August 1st, the movie "Catch the Doll", with the excellent performances of Shen Teng and Mary, successfully broke through 2.4 billion at the box office, which injected vitality into the recently slightly deserted movie market. The success of this film is largely due to the re-engagement of the golden combination of "Shen Ma+Yan Fei Peng Damo". In the process of constructing the universe of Xihong City, directors Yan Fei and Peng Damo have already proved their strength through goodbye mr. loser and The Richest Man in Xihong City. These works are all from their hands, and they have also won a win-win situation for Mahua FunAge in word of mouth and box office. Back in 2003, Beijing Free Element Film and Television Culture Communication Co., Ltd., the predecessor of Mahua FunAge, was founded by three young people with different backgrounds, including Yu Kai of Chinese Department of Peking University, You Liang Tian of Chinese Opera, and entrepreneur Zhang Chen. At first, they tried to adapt the novel into a TV series, but it failed because of the influence of SARS. Subsequently, You Liang Tian turned to the field of drama, and released his first work, I’ll give you a twist if you want to eat it. Although it was initially challenged by the box office, it finally found its own audience in Haidian Theater with its unique style and word-of-mouth fermentation, and Mahua FunAge became famous.

The addition of actors such as Shen Teng, Allen, Wei Xiang, Song Yang and Du Xiaoyu further enriched the cast of Mahua FunAge, and many of them joined through internal recommendation, forming a stable team foundation. Mary, in particular, attracted the attention of Peng Damo for her outstanding performance in the small theater, and eventually became an indispensable member of Mahua FunAge.

The turning point of Mahua FunAge appeared on the stage of the Spring Festival Evening. The skits written and directed by Yan Fei and Peng Damo, especially the role of "Hao Jian" played by Shen Teng, gradually made the team members familiar to the national audience. Despite the enormous pressure of the Spring Festival Gala, the Mahua FunAge team boarded the Spring Festival Gala for many years with unremitting efforts and unique creativity, which not only enhanced its popularity, but also promoted the development of its members’ personal careers, and Shen Teng became an important figure in China comedy movies.

In 2015, goodbye mr. loser, the first work of Mahua FunAge’s transitional film industry, was a great success, which not only verified the feasibility of adapting drama into film, but also opened a new chapter in Mahua FunAge’s film. Subsequent works, such as The Richest Man in Xihong City, faced with speculation about the change of creative team, but Yan Fei and Peng Damo still insisted on their own creative rhythm and style and continued to introduce popular works.

Looking at the development of Mahua FunAge, from the initial exploration to becoming the backbone of comedy, it is inseparable from the tacit cooperation of the core team and the continuous exploration of comedy art. Whether it’s a stage play or a movie, Mahua FunAge always maintains the pursuit of quality and respect for the audience, and continues to bring laughter to the audience.

Welcome to the Autohome Qingdao preferential promotion channel, revealing an exciting car buying opportunity for you! At present, high-profile models are giving back to consumers with great price discounts. In the bustling city of Qingdao, Blue Electric E5 is conducting an unprecedented promotion, with the highest discount reaching an astonishing 40,100 yuan. Surprisingly, the minimum starting price has been reduced to 99,800 yuan, providing car buyers with a very attractive car purchase option. If you are interested in this model, be sure to click the quotation form below to learn more about the preferential policies, and strive to lock in this rare preferential opportunity as soon as possible to realize your car purchase dream.

The exterior design of the blue electric car series E5 shows a simple and technological style. On the front face, it adopts a unique grille design with smooth lines, which not only highlights the sense of power but also the sense of refinement. The overall shape is stable, fusing futuristic and practical, making people recognize its unique identity at a glance.

The Blue Electric E5 shows its side-facing charm with elegant body proportions. The body size is 4760mm x 1865mm x 1710mm, and the wheelbase reaches 2785mm, ensuring the comfort of the interior space. The front and rear wheelbases are 1585mm and 1580mm respectively, providing a stable driving foundation. The tire specifications are quite balanced. The 225/55 R18 tires are selected, and the delicate wheel design is matched, which not only enhances the driving performance, but also adds to the visual movement of the vehicle.

The interior design of the Blue Electric E5 shows a simple yet luxurious style. The 12.3-inch central control screen stands in front of the driver, which is clear and easy to operate. It integrates multimedia, navigation, telephone, air conditioning and sunroof control to provide convenience for the driver. The steering wheel is made of exquisite leather material, which brings a comfortable grip and supports manual up and down adjustment to adapt to the needs of different drivers. The USB/Type-C interface in the car is reasonably distributed, and there is 1 in the front and rear rows, which is convenient for passengers to connect electronic devices. In terms of seats, imitation leather material is used to provide front and rear adjustment, backrest adjustment and high and low adjustment functions. The main and passenger seats are equipped with this comfortable configuration to ensure the comfort of long-distance driving. The second row of seats also supports backrest adjustment to increase the flexibility of the ride space, while the proportional reclining rear seats provide more practical space. Overall, the interior design of the Blue Electric E5 fully considers practicality and passenger experience.

The Blue Electric E5 is equipped with a 1.5L 110 horsepower L4 engine, which can reach a maximum power of 81 kilowatts, which can meet the daily driving needs. The matching E-CVT continuously variable transmission provides a smooth shifting experience and makes the driving process smoother. The combination of this engine and transmission provides the vehicle with enough power and good fuel economy.

Summarizing the views of Autohome owners, the exterior design of the Blue Electric E5 seems to have won its approval. It is described as atmospheric and smooth, and although it is not particularly stunning, it does not fall into the cliché. This modest SUV seems to be suitable for owners who seek practical and understated beauty. Such evaluations have allowed the Blue Electric E5 to find its place in the market and provide a reliable choice for wold-be users.

1905 movie network news On the evening of July 6, the film premiered in Beijing. The director, director, and other creators interacted with the audience through an online meeting. The heroine, Ah Sa, also appeared in the previous live broadcast.

The story of "Detective Wars" revolves around Liu Qingyun’s role as "Detective Crazy". In serial murders, preview murders and other incidents, he and the "Detective Couple" composed of Ah Sa and Lin Wei engage in fierce confrontations.

The plot of the film is ups and downs and confusing, and Liu Qingyun also exchanged notes of "I am a madman" and "I am a detective" to "confuse" the audience at the scene. When it comes to the shooting of "Detective War", he bluntly said that many scenes were very impressive, but the most memorable is the war at the end. He has been tearing this important scene before shooting, and it is very difficult to complete how to control the emotions and how to bring them in. It seems that the acting skills of "Crazy Guy" are also a great test for Liu Qingyun.

Ah Sa, who is on vacation, also helped out for the new film "Detective War" through live broadcast. Gillian, who is on vacation together, also appeared in surprise to play Call for the film. Joey Yung also actively confessed to her idol Liu Qingyun, revealing that she has been a fan of Wei Jiahui and Liu Qingyun since "The Big Times". "When I debuted, I also wrote that Liu Qingyun was my idol, Prince Charming."

On July 8, "Detective War" will be officially released. As a crime suspense film, director Wei Jiahui also hopes that everyone will not spoiler and walk into the theater to experience this exciting story together.

Recently, Ah Kun has been quite emotional. The knowledge of marketing is really extensive and profound, and many manufacturers will choose to promote their products through cross-border marketing. Friends who like sports and basketball recently must have heard that Geely Crossover Basketball has held Geely Colorful China Steel Cannon Basketball Rising Star Trials. It seems that Geely has understood the cross-border marketing part. Then today’s line photo manga "Driving You to Play" is to take you to play basketball.

In the first match of Chengdu Station from June 26th to 27th, dozens of teams competed for the championship of the sub-station and the place to advance to the national finals. On the 27th, Ah Kun, who was photographed in the comics, was fortunate to have zero-distance contact with CBA star Zhu Songwei and streetball expert SOMA, and felt the scope of the game at the scene.

It is reported that this competition uses a 3 + 1 format, consisting of a 3v3 team competition and a 1v1 individual competition, which not only tests team cooperation, but also compares individual strength. In the preliminary round on June 26, in addition to 36 social teams from Chengdu, 12 car owners teams composed of Colorful Car Owners participated together. In the 3v3 confrontation, the social team Amazing team and the Fourman team finally advanced to the finals on the second day.

In the 3v3 final on June 27, just 7 seconds before the end of the game, Fourman’s Serbian player SpaicFilip staged a lore, and after two shots, he successfully leveled the score and reversed the game. In the subsequent 1v1 singles, SpaicFilip once again staged a buzzer lore, successfully leveling the score, but after the on-site referee confirmed through video replay, because Fourman’s last shot was only 0.2 seconds slower, and finally the Amazing ball won the Chengdu social team championship. The intensity of the live game is evident. The car owners team won the Chengdu championship by the Flames.

It is worth mentioning that this event also invited CBA star Zhu Songwei, streetball expert SOMA, and well-known bucklers Chen Junhao, Wan Xu, Xu Wencheng, and Xu Wenhao to the scene of the Geely Colorful China Steel Cannon Basketball Rising Stars Selection Tournament, which aroused cheers from fans at the scene, which undoubtedly heated up the atmosphere at the scene.

Finally, CBA star Zhu Songwei, as the selection officer, announced the MVP of the event – Serbian player SpaicFilip on the spot. Zhu Songwei said: I think talent is important, but hard work is more important. In Serbian player SpaicFilip, I saw the kind of never-admit-defeat struggle. This struggle is also the interpretation of the Battle spirit that Colorful has always passed on for young competition. This spirit of never giving up at any time is also what I have always believed in. In him, I saw myself. And SpaicFilip players will be selected as potential rising stars, and together with the rising stars of Chengdu, Kunming, Changsha and Hangzhou, they will form a new team and go to the Beijing finals.

Subsequently, the streetball expert SOMA also performed at the Chengdu station; the SOMA step of "my true biography" was selected to compete on the spot. Chen Junhao, Wan Xu, Xu Wencheng, and Xu Wenhao participated in the dunk contest, and SOMA, Zhu Songwei, and Geely representatives were the judges. The audience brought wonderful performances such as dunk, dunk, front dunk, reverse dunk, and fancy dunk. Finally, Xu Wenhao won the championship of the dunk contest. SOMA and Zhu Songwei made professional comments on the competition and provided valuable experience and suggestions to the dunkers.

Geely’s representative commented on the players: the original intention of the sportsmanship event that keeps fighting is very suitable. As a high-performance SUV built for young people, Colorful not only satisfies young people’s pursuit of performance with the strength of Chinese steel cannons, but also hopes that such a model with a battle spirit can truly inspire young people, allowing young people to battle and enjoy, just like perseverance and struggle on the field of love, competing for young people.

At the scene, in addition to exciting basketball games, spectators can also participate in swtich games, DIY painting, fun dunks, manicures, and Geely Colorful test drives in the interactive area, and participate in a weekend party in person.

As a global model created by Geely for young people, Geely Binyue has a stable structure with BMA modular architecture, 7.9S zero-hundred acceleration performance and sporty appearance, which has attracted some young people. This time, Geely Binyue further bundles "basketball" and "car". Through the creation of basketball IP, it encourages more people to participate in basketball, helps basketball fans chase their basketball dreams, and discovers more potential and possible young players to help the development of Chinese basketball culture. The next stop, Kunming Station, will be held on July 10-11. Friends who like battle may wish to look forward to it.

Text | Photographs, Ah Kun

　　Million Chinese stars, subversion and start again! Recently, Geely China Star Intelligent Dual Engine once again challenged the high difficulty, bravely picking the three major landmarks of Japan’s Tsukuba Circuit, Qiumingshan and Tomei Line, and achieved outstanding performance such as 7.92s 100 kilometers acceleration, 79.9km/h elk, and 4.3L 100 kilometers fuel consumption. It also set the fastest lap record of the first Chinese A-class sedan at Tsukuba Circuit with a lap time of 1:18.03, demonstrating high performance, strong control, and low fuel consumption. All-round hardcore strength. With 1.5TD four-cylinder hybrid special engine + the world’s leading three-speed intelligent frequency conversion technology + X · System intelligent control system and other innovative technologies, China Star Intelligent Dual Engine has broken the long-standing technical barriers of oil mixing, achieved energy-saving, performance and intelligent balanced development, with Chinese solutions and Chinese standards, leading the global oil mixing technology to continue to advance, and quickly entering the more advanced, smarter, safer and more comprehensive Chinese "Star" era.

　　As a classic "Holy Land of Brushing Circles" and F3 race base in Japan, Tsukuba Circuit has a unique design of 8 complex curves including short and compact, low-speed compound curve + high-speed curve + hairpin curve, which places extremely high requirements on the driver’s driving technology and the vehicle’s dynamic performance and control and other comprehensive mechanical qualities. Faced with such a difficult challenge, China Star Intelligent Dual Engine has no stage fright, with 7.92s 100 kilometers acceleration, 34.65m braking distance, 79.9km/h elk, 1 minute, 18 seconds and 03 laps, etc., leading the Japanese Dual Engine products of the same level in an all-round way.

　　China Star Intelligent Dual Engine’s leadership lies not only in its strong power performance, but also in the field of fuel economy. In the fuel consumption test project of the Dongming Line, after 1.5 hours and 104km of uninterrupted driving, the fuel consumption is only 4.3L/100km, and the actual fuel consumption measured by the refueling method is 4.46L/100km. The strength catches up with the same level of oil-mixed models.

　　Behind the outstanding results is the strong confidence and confidence given by the technological innovation of China Star Intelligent Dual Engine. Compared with the Japanese equivalent oil-mixed products, which are mainly fuel-saving self-priming engines + single-speed electric drives, China Star Intelligent Dual Engine is equipped with a 1.5TD direct injection turbocharged hybrid special four-cylinder engine with a thermal efficiency of up to 44.26% as standard, which can release 120kW maximum power and 255N · m maximum torque; then matched with the world’s leading 3-speed intelligent frequency conversion DHT, supports P1 + P2 dual motor drive, and can enter the full speed domain at a speed of more than 20km/h. The maximum wheel end output torque is 4920N · m, and the torque-to-mass ratio is 41N · m/kg. The maximum transmission efficiency is up to 97.5% in the world, with almost no energy loss. Low-speed electricity consumption, medium-speed fuel-saving, and high-speed power supply, China Star Intelligent Dual Engine’s strength subverts the inherent cognition of "hybrid only energy-saving, no performance" shaped by traditional oil-mixed products in the past, and provides users with a new generation of Chinese hybrid solutions and options that "balance performance and fuel-saving".

　　If the Tsukuba Circuit and the Tomei Line in Japan demonstrate the pinnacle of China Star Intelligent Dual Engine’s power performance and energy conservation, then the "holy land of running mountains" in the hearts of many racers, Akiyama Mountain, is the best test ground to show the powerful handling strength of China Star Intelligent Dual Engine. The mountain road of only 3 kilometers has steep twists and turns, with more than 30 corners, and an average of nearly 180 degrees every 100 meters. The road down the mountain is thrilling and exciting, which greatly tests the vehicle’s handling performance and the mechanical quality of the vehicle.

　　Relying on the natural good foundation given by the world-class CMA architecture, L Intelligent Engine is supported by the world’s leading wire-controlled chassis technology, McPherson front suspension, multi-link independent rear frame, ZF DP-EPS steering power system, and the longest suspension stroke design of the same level. With strong grip and excellent corner handling, it can quickly respond to the driver’s intention and accurately feed back road condition information. Whether it is entering a corner, bending, or exiting a corner, the whole vehicle body posture is very beautiful and smooth, bringing a driving texture that combines driving comfort and sports control. Especially under the inherent advantages brought by the 29000N · m/deg torsional stiffness comparable to millions of luxury cars, the dynamic roll stiffness of 3.65deg/g, and the negative camber design of the only racing car in the same class, Xingrui L Intelligent Engine still performs well in the famous five-star autumn famous mountain hairpin bend, which not only accurately locks the wheel track, ensures the accuracy and flexibility of the vehicle, but also enhances the vehicle’s cornering grip and agility, bringing excellent driving confidence and racing-like attacking and cornering experience.

　　No frequency conversion does not save energy, and no performance does not subvert. From the dynamic performance test of Tsukuba Circuit, to the 104km fuel consumption test of Dongming Line, and then to the control test of Qiumingshan, China Star Intelligent Dual Engine has fully confirmed that China Hybrid has the strong strength to subvert the hybrid pattern and redefine the new standard of global hybrid value with excellent performance and leading technical confidence.

　　It is with this kind of product confidence and strong technical confidence that has been rooted in the bones of "not trying is not better than not selling" since its birth, China Star has always insisted on creating high value, constantly breaking through and subverting along the way, running out of China’s "Star" speed, becoming the first high-end series in China’s A-class fuel vehicle market to break through 1 million sales; among them, Xingrui and Xingyue L have entered the hinterland of the A-class mainstream fuel vehicle market, and in April they ranked No. 1 in China’s fuel SUV and sedan sales, leading the new pattern of China’s fuel vehicle market.

　　The next million-dollar era has begun! China Star, China Auto, has never been afraid of head-on competition, dared to show the sword, and let the world see the confident rise and powerful power of Chinese manufacturing.

Feature: Picture Channel

Topic: The devastating earthquake in Wenchuan, Sichuan

Feature: Fighting the Earthquake: The Cutest Soldiers

　　On the 19th, Jackie Chan and young players Wang Wenjie and Liu Fengchao showcased their fists at Cannes

　　On May 19, local time in Cannes, Jackie Chan appeared in Cannes to promote the kung fu film "Wushu Youth", which he was the producer of. Although the original intention of the producer of the film was to cultivate and recommend kung fu newcomers, due to the earthquake in China, Jackie Chan also shifted the focus of the topic to focus on the disaster situation, saying that he would temporarily put aside other work at hand to concentrate on setting up a special fund for disaster relief and planning large-scale disaster relief performances.

　　Working on establishing a fund for disaster areas

　　Jackie Chan revealed that when he learned of the earthquake in the country, he was considering how to give some help to Myanmar, but he heard the news before the plan was discussed. Before coming to Cannes, Jackie Chan had been busy with disaster relief, and he would leave immediately after the event to continue the relief work.

　　"After the earthquake, every Chinese person is contributing money, but the reconstruction work after the disaster is the most important, so I won’t go anywhere now, put aside other work at hand for the time being, and focus on doing something for the disaster relief." Jackie Chan said that the disaster will not pass in a day or two, and may take up to seven or eight years to rebuild. "I am busy setting up a special fund for disaster relief, so that I can give some help to the disaster area every year. Now how to appease those children and help their spiritual health is the most important thing."

　　"We have a strong cohesion."

　　Jackie Chan had previously donated 10 million yuan to the disaster area with Emperor boss Yang Shoucheng, and he himself went to the disaster area in Sichuan. Speaking of his feelings at the time, Jackie Chan said: "My car was driven by a police car, but the cars on both sides were delivering supplies on one side, and the other was empty cars coming back. There were also many people riding bicycles to send supplies. The touching deeds of the frontline personnel made me cry dry."

　　Jackie Chan’s influence in the world film industry has attracted a large number of overseas media. He said publicly at the press conference: "Money is not a problem in China now, we have too much money. What I feel the most about this is that I see the strong cohesion of our Chinese people."

　　In addition, when asked by overseas media about some negative reports about the Beijing Olympics, Jackie Chan replied: "Many reports are untrue and there are too many misinterpretations. I love sports, I believe everyone loves sports, and the Olympic Games are not only the Olympic Games in China, but also the Olympic Games in the world."

Editor in charge: Zhang Tuoya