Zhang Hanyu plays Zhang Liang and pats the play for the first time.

　　The historical masterpiece "The Hongmen Banquet" will be released nationwide on November 29th. As the soul of this historical dinner in the film, Zhang Hanyu presented his first performance in the Qin Dynasty for Zhang Liang, the "first counselor", and even refused body double from beginning to end. In the bloody stills exposed today, Zhang Hanyu, who has always been gentle and gentle, raised a knife and charged to kill. Director Li Rengang commented that his play was "killing and yelling, which was very infectious". After that, Zhang Hanyu laughed and said that as a sage, "You don’t have to bring a knife if you walk in the rivers and lakes with wisdom."

History Zhang Liang is proficient in fencing.

　　It is reported that Zhang Hanyu first received an invitation from The Hongmen Banquet and thought he would play Liu Bang. When he learned that he was going to play Zhang Liang, his first reaction was that he couldn’t play it at all. It turns out that Zhang Liang in Zhang Hanyu’s mind is a calm white-flour scholar. I didn’t expect this sage in the play to be proficient in fencing, and he also took soldiers to practice swords every day. "In fact, Zhang Liang is really a man with both civil and military skills in history," Zhang Hanyu told reporters. Zhang Liang is a descendant of Korean aristocrats. After Qin destroyed Korea, he assembled 200 soldiers to practice martial arts and decided to fight against Qin and restore Korea. "So he is the leader of the underground anti-Qin organization and belongs to the leader of the Jianghu resistance group. His martial arts are prepared for the rejuvenation of the country. "

I was so tired that I refused to use martial arts.

　　Zhang Hanyu’s play in person is about Zhang Liang’s troops ambushing in the pass of Qin Shihuang, ready to assassinate him. Zhang Liang wanted to kill him and cut him on the chariot with a big knife. For 47-year-old Zhang Hanyu, Zhang Liang’s profundity and resourcefulness are not difficult to control, but when it comes to acting, it’s hard to break the emperor who has never filmed martial arts. The weather was hot on the day of the official shooting. From noon to six o’clock in the afternoon, he was photographed in a thick white robe and was close to collapse. His clothes were soaked through several sets. "I didn’t pick up a lot of dramas before. This time it is for the plot. "

　　Specific to the action of playing opera, Zhang Hanyu revealed that there won’t be too many fancy styles, but mainly swing and chop. "I don’t really like that kind of play. It’s fake and the audience is tired of it. It’s better to actually punch the meat. That mainly depends on the state of the characters and the atmosphere! " For this screen maiden fight, "I practiced my back for several days."　

People can leave the knife when floating in rivers and lakes.

　　Three people stabbed Qin three times in history, one was Jing Ke, the other was Gao Jianli, and the other was Zhang Liang. Zhang Liang also went into exile because of the failure to assassinate Qin Shihuang. Although it is recorded in historical records that Zhang Liang stabbed Qin with a 120-pound sledgehammer. However, in The Hongmen Banquet, the director deliberately created a sword-like weapon to show Zhang Liang’s martial arts. "The long handle, with both hands, is more like a broadsword." When the reporter asked how many scenes used this weapon, Zhang Hanyu smiled humorously: "I stabbed Qin once, but never appeared in the middle. I (referring to Zhang Liang) am a person who walks the rivers and lakes by wisdom, and then I don’t need a knife. "　

More wonderful pictures on the next page

　　A friend of mine bought a car last year, and his goal was the urban SUV model. The requirement was to save fuel and worry. I accompanied him to many 4S shops and finally chose Toyota Willanda. I had supper with him the other night, and I drove a Toyota Willanda for a year. He felt that the car was good in all aspects. So today I want to talk about Toyota Willanda, so let’s take a look at this car.

　　My friend bought the 2020 Verlanda 2.0L four-wheel drive technology version, and the official guide price of this car was 225,800 yuan. He bought it when it was just listed last year, so the discount was not strong. At that time, the discount price for naked cars in Wuhan was 222,700 yuan, the purchase tax was 19,198.28 yuan, the license fee was 500 yuan, the vehicle and vessel use tax was 480 yuan, and the traffic insurance was 950 yuan, so the commercial insurance was 6,416.14 yuan, so the landing cost was 2,400 yuan. Of course, this is the price he bought last year. If he buys it now, it should be a few thousand dollars cheaper, but buy the car early and enjoy it as long as you like it.

　　

　　

　　The shape of Willanda still continues the Toyota family design concept. From the head of the car, the outline is full, the lines are rounded, and the headlights are slightly sharp. The slender front grille is connected with the headlights on both sides and integrated with the logo in the middle. The lower grille is wider and adopts trapezoidal polygon style, and the lower part and the front lip of the car form a whole, extending further to both sides. The front of the car is widened visually, which has a big mouth effect and looks more visual tension.

　　

　　The side of the four-wheel drive technology version looks really technical, and the blackened roof is particularly fashionable. The wide wheel eyebrows are geometric shapes with sharp edges and corners. The shape of the hub is unique, with a five-pointed star inside and hot wheels outside. The lines on the head of the car are more rounded, the tail is angular and angular, and the sense of strength is more sufficient. 4665x1855x1680 mm in length, width and height, and 2690 mm in wheelbase, it is a compact SUV, and its parameters are in the upper-middle level compared with those of its class.

　　

　　

　　The shape of the rear of the car is simple, narrow at the top and wide at the bottom, surrounded by a thick black bottom, and decorated with silver decorative strips. There are also silver horizontal decorative strips in the middle of the taillights, which makes the upper and lower parts more unified and coordinated, and the circular double-outlet exhaust pipes are full of sports style.

　　

　　

　　When I came to the interior of the car, the design of the interior was quite satisfactory. The suspended central control LCD screen had a thick frame and a slightly insufficient sense of science and technology. The upper level of the center console is rich, with a large area of leather wrap. The buttons below are arranged neatly, which actually gives a good damping feeling, and the workmanship is also exquisite, and the smell of the new car is small, and the materials used are quite particular.

　　

　　

　　The ride in the car is comfortable, and the padding inside the seat is moderate in hardness, strong in wrapping and good in support. The riding space is relatively spacious. I am 1.75 meters tall. I sit in the main driver’s seat with more than one punch in the head. I sit in the second row. I adjust the front seat to a suitable position, with two punches in my legs and four fingers in my head. Compared with other cars of the same class, I am in the upper-middle level. There are some bumps in the middle of the floor, which have some influence on the ride comfort.

　　

　　The trunk is not particularly large, but it has no problem as a daily household, with a volume of 580 liters. From the parameter point of view, it is in the upper-middle level of the same class, and the trunk is relatively regular, with good horizontal and vertical space. Usually, when you go to the supermarket for shopping, this trunk is definitely enough. When you go out to go on road trip, you can put a lot of luggage.

　　

　　In terms of power, the 2.0L four-cylinder naturally aspirated engine has a maximum power of 171 HP, matching the CVT gearbox. Abundant power reserve, good linear acceleration performance, easy overtaking, quick throttle response and very flexible starting when commuting in the city. There is no feeling of frustration when CVT gearbox drives at low speed, the power output is also very smooth, the steering wheel steering is also very accurate, and the car is quite easy to drive.

　　The fuel consumption of the four-wheel drive version is higher than that of the two-wheel drive version. The comprehensive fuel consumption of the Ministry of Industry and Information Technology is 6.4L Because the car is mainly used for commuting, the road conditions are not very good when using the car at ordinary times, and there are frequent traffic jams. My friend’s car drives 12,000 kilometers a year, almost 2,000 kilometers at high speed, and the rest are running in the city. At present, the comprehensive fuel consumption is 9.8L Thanks to the technology of VVT-i intelligent variable valve timing electronic control system, the fuel consumption performance is quite satisfactory.

　　

　　McPherson independent suspension+double wishbone independent suspension, timely four-wheel drive, good vibration filtering performance of the chassis, which is more suitable for urban roads. After passing through some small gravel roads, you can hardly feel any vibration when sitting in the car, and it is quite quiet and very comfortable.

　　

　　In terms of off-road capability, the approach angle of the car is 17.8 degrees, the passing angle is 14.4 degrees, the minimum ground clearance is 170 mm, and the departure angle is 20.1 degrees. This car can handle all kinds of roads, national roads, county roads, township roads and Panshan roads, even some muddy unpaved roads, and there is not much problem. Compared with the city SUV of the same level, the passability is good, but it is really not an off-road vehicle, so don’t drive it to a bad place, you may not be able to get out of trouble.

　　Generally speaking, the product strength of Toyota Willanda is quite good, the performance of the car on the road is quite excellent, and the off-road genes are not very sufficient, that is, it is a home city SUV that is comfortable to drive and quite fuel-efficient, but don’t toss it as an off-road vehicle.

Compared with the price of similar anti-cancer drugs, a box of "life-saving drugs" as long as 290 yuan is included in medical insurance is particularly warm.

This medicine, namely tretinoin capsules, also called retinoic acid capsules, is specially used for the treatment of acute promyelocytic leukemia. It greatly improves the survival rate of patients with leukemia and becomes the first tumor that can be cured in the history of human tumors.

This specific medicine comes from Wang Zhenyi, an expert in internal medicine and hematology in China.

At the beginning of the successful development of tretinoin capsules, Wang Zhenyi had two choices: one was to apply for a patent for this specific drug. After the application is approved, such drugs will be as expensive as similar "specific drugs". As long as you hold the patent, you can eat and drink; The second is to give up patent application, so that such drugs can be included in medical insurance at a low price and help more patients.

At that time, Wang Zhenyi hardly hesitated and firmly chose the latter.

Let the tumor "turn over a new leaf"

The development of tretinoin capsules originated from Wang Zhenyi’s research on acute promyelocytic leukemia.

This is a special type of acute myeloid leukemia (AML), which is classified as M3 type by FAB collaboration group. Once the disease occurs, a large number of leukemia cells in the patient’s bone marrow and other hematopoietic tissues will proliferate indefinitely and enter the peripheral blood, greatly inhibiting the production of normal blood cells.

The most typical characteristics of this type of leukemia are unclear etiology, acute onset, dangerous condition and rapid deterioration. Without timely and effective treatment, many patients will die within six months.

Academician Wang Zhenyi

At that time, Wang Zhenyi learned from sporadic overseas research progress that some foreign doctors were trying an all-trans retinoic acid therapy. Generally speaking, the idea of this therapy is to induce the problematic M3 cells to differentiate into normal cells. This new therapy immediately attracted the attention of Wang Zhenyi, and quickly launched the relevant research.

In 1986, Wang Zhenyi met a 5-year-old patient who was dying of acute promyelocytic leukemia. After analyzing the little girl’s condition, he carefully discussed with the patient’s family whether he would like to try this new drug.

With the consent of his family, Wang Zhenyi never imagined that the biggest resistance actually came from "one of his own".

At that time, Wang Zhenyi was 62 years old and was an expert in related fields in China. Therefore, when I heard that he was going to try this new drug on patients, many people came to persuade him: you have made a success, so don’t toss about. If the treatment doesn’t go well, it will ruin the reputation accumulated for many years, and the loss will outweigh the gain.

But Wang Zhenyi was firm: I did it for the patients. And we have experimental basis, and I believe in science.

In this way, the little patient ate tretinoin capsules. In just one week, her condition turned for the better, and the situation got better and better, and she was finally cured and discharged.

This case has also become the first successful case that the globally recognized theory of induced differentiation has made cancer cells "correct evil".

I decided to give up the patent.

The success of this case greatly increased Wang Zhenyi’s confidence in the research content.

After that, he and his students Chen Zhu and Chen Saijuan creatively proposed the treatment method of all-trans retinoic acid combined with arsenic trioxide. After the birth of this method, it was once regarded as the most dangerous acute promyelocytic leukemia and became the first leukemia that can be cured in the world. This treatment method has also been praised as "Shanghai Plan" by overseas media and listed as "Eight Contributions of New China to World Medicine" with the invention of artemisinin.

What is opposite to the extremely high evaluation of the outside world is the almost "low" price of this specific drug.

This sharp contrast is precisely because Wang Zhenyi chose to "give up the patent".

Academician Wang Zhenyi

When asked why he made such a choice, Wang Zhenyi took out his school motto when he graduated from the Medical College of Aurora University in 1948. Two of them were specially marked by him, which read: The rest of the sick should be treated carefully, not discriminated against because of the rich and the poor, and should do their best to study with its evolution in order to benefit the crowd; I will never accept ill-gotten gains in addition to proper medical treatment.

Wang Zhenyi said frankly that one of the reasons why he chose not to apply for a patent was that he didn’t have a clear patent consciousness at that time, but more importantly, he was always thinking about treating patients quickly. The examination time for applying for a patent is not short. Compared with the other, he hardly hesitated and chose to give up.

In 2020, Wang Zhenyi won the 2020 Future Science Award for Life Science with a prize of $1 million for her outstanding achievements in the treatment of acute promyelocytic leukemia.

Wang Zhenyi once said: "The doctor is to solve the patient’s problem."

This award is the greatest affirmation and respect for his research achievements and medical spirit over the years.

Read the original text

　　On February 15th, 2023, Spring Festival travel rush officially closed. In 40 days, railways, highways, waterways and civil aviation have sent more than 1.5 billion passengers. People who packed their bags, with the blessings of their loved ones, rushed to the far and wide again, interwoven into a warm picture of China.

　　The best time on earth is early spring. As the first Spring Festival travel rush after the epidemic prevention and control entered a new stage, people have realized their dream of reunion, and are also moving forward for the new goal and new atmosphere of the new year.

　　The passenger flow is rising and the traffic is smooth, and the mobile China is full of vitality.

　　On February 14th, 2023, Spring Festival travel rush is drawing to a close, but Asia’s largest railway passenger transport hub — — Beijing Fengtai Station is still busy. Travellers from the south to the north, dragging their luggage and carrying their hometown specialties, set foot on their way back to work and school under the guidance of the station staff.

　　"This year, the passenger flow in Spring Festival travel rush has increased significantly, and our work has become more busy. However, seeing the normal flow of people in cities and stations, passengers’ faces are filled with happy smiles, and all our service guarantees are worthwhile. " Ling Chengcheng, chief of the comprehensive support section of the Beijing Fengtai Station District Management Office of the Beijing Key Station District Management Committee, said.

　　The EMU train stops at the storage line of Wuhan EMU (photo taken on January 7, photo of unmanned aerial vehicle splicing). Xinhua News Agency reporter Wu Zhizun photo

　　Compared with Spring Festival travel rush in previous years, during Spring Festival travel rush in 2023, the passenger flow of railway Spring Festival travel rush continued to rise. According to the data, since February, the national railways have sent more than 9 million passengers per day and operated more than 9,000 passenger trains, basically recovering to 90% of the same period in Spring Festival travel rush in 2019.

　　As a popular means of transportation, railway bears the responsibility of ensuring the long-distance and large-scale flow of population. As the first choice for short-distance travel, road travel is also favored by the public in this year’s Spring Festival travel rush.

　　"From Spring Festival travel rush to the fifteenth day of the first month, the service area appears almost every day ‘ Super busy ’ State, the passenger traffic in the 360 service areas under our jurisdiction increased by 2 to 4 times year-on-year, and the overall turnover also increased significantly compared with the same period of last year. " The relevant person in charge of Guangdong Tongyi Expressway Service Area Co., Ltd. said.

　　According to the data from Didi Chuxing, from January 7 to February 14, Didi’s car and taxi order calls continued to grow, and they have recovered to more than 90% in the same period in 2019. Among them, Beijing, Shanghai and Guangdong recovered over 90%, and Shenzhen recovered nearly 90%. In addition, the demand for taxis in second-and third-tier cities such as Dalian, Yancheng, Nanchang and Mianyang has also increased significantly.

　　Passengers lined up at the entrance of Shenzhen North Railway Station (photo taken on January 18). Xinhua News Agency reporter Mao Siqian photo

　　The continuous growth of passenger flow and the orderly road in the busy schedule highlight the vitality and vigor of the mobile China — —

　　After the Lantern Festival, in the Shanghai Railway Station of Shanghai Metro Line 1, people carrying big bags and small bags passed quickly and orderly under the guidance of staff and police. The bustling scene made many people feel that "the busy international city is back";

　　During the Spring Festival, Sanya Air Traffic Control Station reached a new high, with a total of 3,024 flights in seven days, an increase of 5.8% over the same period in 2019. "Now the apron is full of planes, and the number of wide-body aircraft and business jets has increased significantly";

　　In the second half of Spring Festival travel rush, the number of passengers carried by passenger ships under the jurisdiction of Shandong Weihai Maritime Safety Administration increased significantly, and the daily average number of passengers carried remained at around 20,000, an increase of 192% compared with the first half of the year & hellip; …

　　"Overall, the operation of railways, highways, waterways and civil aviation in the country has remained stable, with adequate capacity allocation, orderly services and strong emergency support, and the national security situation is generally stable." Zhou Wei, deputy director of the Emergency Office of the Ministry of Transport, said.

　　Excellent service and further upgrade will help Spring Festival travel rush to be safe and smooth.

　　When Aunt Tang, who had never flown alone, entered the T3 terminal of Shenzhen Airport, Peng Yihan, an airport worker who had been waiting for a long time, was greeted: "Aunt Tang, your son applied through the airport hotline ‘ Whole-process assistance for elderly travelers ’ Love service, I will accompany you to the boarding gate. " Accompanied by the staff all the way, Aunt Tang successfully boarded the flight back to her hometown in Xi ‘an.

　　In Spring Festival travel rush this year, "warm heart service" became one of the key words.

　　A number of airports and airlines have upgraded the "first-time passenger service" in an all-round way, providing full-process services such as check-in, security check-in and waiting for flights for first-time passengers; 12306 Continue to improve the transfer plan, train operation and information related to "food, accommodation, travel and purchase" to make it more convenient for passengers to obtain information; The service of "Smooth Train" has covered more than 3,400 emus of 18 railway bureau group companies. Passengers can check the information of the train’s delay and running position by scanning the "Smooth Train" code on the armrest of the seat … …

　　On January 30th, 531 migrant workers from Dingxi, Gansu Province took the G1904 train from Dingxi North Station and went to Fuzhou, Fujian Province, more than 2,000 kilometers away, to start a new year’s migrant journey.

　　Under the guidance of the staff of Dingxi North Station in Gansu Province, migrant workers are preparing to take the free high-speed train for returning to work to Fuzhou, Fujian Province (photo taken on January 30). Xinhua News Agency (photo by Wang Guanghui)

　　"From Dingxi to Fuzhou, the ordinary train takes more than 30 hours, and this high-speed train only takes more than 13 hours." Shi Xuexia, who works in an automobile motor factory in Fuzhou, said that when she arrived in Fuzhou, there was a special car in the factory to pick her up for work.

　　China Railway Chengdu Bureau Group Co., Ltd. took the initiative to find out the number of trips, and launched a total of 24 "point-to-point, one-stop" direct return trains, with a transportation capacity of 14,000 passengers; Yunnan has organized more than 1,460 "point-to-point" transportation services, such as "special buses for workers, special trains and charter flights", which have helped 49,300 rural laborers realize the transfer of employment … … Towards a struggle and a better life, cars, high-speed trains and planes continue to travel.

　　Cyclists returning home rest at Spring Festival travel rush Qingwen Station at the east exit of Wuzhou City, Guangxi (photo taken on January 7). Xinhua News Agency reporter Huang Xiaobang photo

　　Security is a constant theme in Spring Festival travel rush.

　　In Hami, Xinjiang, in the extremely cold weather, the law enforcement officers of the Barkun Law Enforcement Brigade of Xinjiang Transportation Comprehensive Administrative Law Enforcement Bureau waded knee-deep in snow to find trapped vehicles, and guided the trapped people to rest in the nearby service area one by one, and provided meals and accommodation; At the same time, snow removal and deicing equipment such as snow removal vehicle, sweeper and snow melting agent distributor are used to ensure smooth roads.

　　"During the period of Spring Festival travel rush, tens of thousands of cars went out of Xinjiang through the G7 Jingxin Expressway every day. What we are most worried about is the windy and snowy weather, which is likely to cause vehicle failures and frostbite." Tao Zhiliang, secretary of the Party branch of the Barkun Law Enforcement Brigade, said that the weather is getting warmer now, and the brigade will make preparations for preventing avalanches and flood control in spring.

　　The crew of China Southern Airlines carried out deicing and anti-icing operations at Longdongbao International Airport in Guiyang (photo taken on January 17). Xinhua News Agency reporter Yang Wenbin photo

　　Ensure the prosperity of materials and freight, and run forward in the new year.

　　Zhejiang, Yiwu West Railway Station, trucks enter and exit in an orderly manner, and gantry cranes load containers on the "Yixin Europe" Central European train. The "steel camel team" full of goods is ready to go, injecting strong vitality into China’s foreign trade and economic cooperation.

　　Statistics show that in January this year, "Yixin Europe" China-Europe Yiwu platform operated 240 trains and sent 20,140 TEUs, with a year-on-year increase of 172.1%.

　　“‘ Yixin Europe ’ The shipment volume of the China-Europe Yiwu platform has grown steadily, reflecting the strong resilience and great potential of China’s economy. " Bei Xudong, deputy director of Yiwu Municipal Market Development Committee, said that during Spring Festival travel rush, railways, ports and other relevant departments made scientific overall plans and coordinated in advance according to the transportation demand and supply organization of foreign trade enterprises to ensure the smooth running of trains during Spring Festival travel rush.

　　The speeding trains reflect the steady economic recovery of China; The smooth road network weaves the people’s livelihood and well-being of all households in China.

　　A Central European train loaded containers at Dulaying Station of Guiyang International Land Port (photo taken on February 9, photo of drone). Xinhua News Agency reporter Liu Xushe

　　As dawn dawned, Master Gui, a truck driver in Shenzhen, came to the warehouse area to count the goods to be sent out that day with the store. "I am really happy to see that the merchants are busy!" Master Gui said that in the past two weeks, the merchants in the market have been busy, and the passenger flow has returned to 70% to 80% of the normal level before the epidemic.

　　According to the platform data, the freight market in Shenzhen opened higher after the Spring Festival holiday. From January 31 to February 7, the freight order volume in Shenzhen increased by 117% compared with the same period of last year. On average, more than 6,000 drivers run on the road every day to take orders actively.

　　Spring is not a mistake, and autumn is not. North and south of the river, farmland is busy.

　　On the outskirts of Kunming, Yunnan Province, Taohuacun Railway Station, 6 forklifts are working continuously. Within one hour, the staff loaded all 360 tons of chemical fertilizer into the carriage. Soon, these fertilizers will be transported to Shandong, Hebei and other places to provide nutrients for crop growth.

　　In view of the obvious increase in the transportation demand of spring ploughing production materials, several railway stations in Kunming have strengthened communication and coordination with neighboring fertilizer production enterprises, helped enterprises to "tailor-made" fertilizer transportation plans, and implemented the "four priorities" service of giving priority to planning, giving priority to air distribution, giving priority to loading and giving priority to hanging.

　　Workers carry out transportation operations on the production line of Tianan Chemical Phosphate Fertilizer Manufacturing Center of Yuntianhua Group in Anning City, Kunming, Yunnan Province (photo taken on February 8). Xinhua News Agency reporter Jiang Wenyao photo

　　According to statistics, China Railway Kunming Bureau Group Co., Ltd. has transported more than 15,000 vehicles and 919,000 tons of spring ploughing materials in 2023, with a year-on-year increase of 16.6%. The cars passing through the mountains and tunnels are carrying the hope of a bumper harvest and reaching countless distant places.

　　After 40 days and nights, Spring Festival travel rush came to an end and saw beautiful spring scenery. Spring Festival travel rush is the starting point for the revival of all industries. People are full of energy, confident and calm in the season full of hope, and strive for a brighter new year.

　　Text reporters: Ye Haoming, Ruta, Wei Hongyi, Fan Xi.

　　Poster design: Excellence

　　Fans seized the subway billboard to celebrate the idol’s birthday. After the idol announced his love affair, fans ran away and cried, and even fans blocked the star’s door for several months. The star had no choice but to send Weibo to vomit … … More and more cases of crazy idolize make people realize the importance of rational idolize while being shocked.

　　Last week, a survey of 2009 people was conducted by the Social Investigation Center of China Youth Newspaper, and it was found that 80.6% of the respondents were surrounded by people who were crazy about idolize. 55.5% of the respondents believe that the biggest harm of crazy idolize is wasting a lot of time, and 52.2% of the respondents believe that rational idolize can bring positive energy to life.

　　Among the respondents, 1.4% were born after 00, 26.6% after 90, 48.6% after 80, 16.6% after 70, 4.6% after 60 and 1.6% after 50.

　　80.6% of the respondents were surrounded by crazy idolize people.

　　The elder sister of Qiu Rui (pseudonym), a senior student in a university in Beijing, is a fan of an entertainer. When the idol openly fell in love, "she cried in the room all afternoon and bought tens of thousands of cosmetics online on impulse".

　　In the survey, 80.6% of the respondents said that they were surrounded by crazy idolize people, and 12.9% of them were surrounded by many such people.

　　I will watch the movie made by my idol at the first time and buy his album and some peripheral products. For Chen Xiaoying, an employee of an Internet company, idolize means "always willing to support idols".

　　Chen Luxin, a graduate student in Beijing, is also a fan of an entertainment star. She introduced that joining a fan group is a "key step" in the process of idolize. If you can achieve a higher level in the fan group, you can even get the opportunity to chat and eat with idols.

　　Among various forms of idolize, watching variety shows, movies and TV series in which idols participate (61.2%) is the most reasonable behavior of idolize. Other behaviors are: attending concerts, meetings and other performances of idols (55.6%); Buy albums, photos and books of idols (53.8%); Pay close attention to idols on social networking sites (38.4%); Attend fan parties (22.2%); Join the fan support group (16.8%); Pick up the plane for idols (11.3%); Giving idols high-priced gifts (9.2%); Waiting at idol companies, shooting studios and other workplaces (8.6%); Travel time is consistent with idols (6.8%); Standing on the opposite side with fans of other stars (5.4%).

　　55.5% of the respondents believe that the biggest harm of crazy idolize is wasting a lot of time.

　　Chen Xiaoying thinks that some people who lack goals in life will take a star as their goal, and they are crazy about idolize.

　　Chen Luxin has been in idolize for three years. At first, she didn’t quite understand many idolize behaviors. "But after a deep understanding, I found that idol experiences and songs can give me a lot of strength, and she will gradually become dependent."

　　So, what are the reasons for the crazy idolize phenomenon? 53.1% of the interviewees think it is normal idolatry in adolescence, 48.7% think it is due to lack of emotional sustenance, 44.4% think it is due to lack of clear goals in life, and others are: out of vanity and comparison (40.4%), over-fantasizing about their close relationship with stars (30.6%) and making themselves unique through idolize (24.7).

　　"idolize should be measured. We will also resist the crazy containment and sneak shots of idols. " Chen Luxin said.

　　After experiencing the emotional breakdown of her sister idolize, Qiu Rui realized that "you can’t concentrate all your energy on idols, otherwise you will get hurt too easily". Chen Luxin believes that idolize can bring positive energy as long as it keeps a healthy mind.

　　According to the data, wasting a lot of time (55.5%), bringing economic pressure to themselves and their families (53.2%) and neglecting relatives and friends around them (43.7%) are the three major injuries that respondents think crazy idolize brings. Others include: delaying one’s future (35.8%); Interfere with the normal life of stars and infringe on their privacy (32.8%); Many things cannot be evaluated objectively and rationally (30.7%); Emotion is easy to fluctuate and more vulnerable than others (30.5%); Idolize suffered psychological trauma (26.6%) and was used and cheated by criminals because of idolize (18.7%).

　　On the evaluation of idolize’s behavior, 52.2% of the respondents think that rational idolize can bring positive energy to life, 38.9% of the respondents think that everyone has the freedom to choose his idol, and 26.8% of the respondents think that idolize’s behavior itself is understandable. In addition, 47.1% of the respondents feel that idolize should not hurt the feelings of relatives and friends around him; 41.0% of the respondents feel that crazy idolize will affect their lives and those of others and should be avoided; 22.7% of the interviewees admitted that idolize was impetuous and over-entertained.

　　43.0% of the respondents believe that fans should be in idolize within their own financial ability.

　　"My roommate in college was ‘ Idolize clan ’ She kept introducing me to the news of her idol every day. " Chen Xiaoying said frankly, "After a long time, I will feel a little bored."

　　What influence does it have on you to have idolize around you? The data shows that 34.6% of the respondents said that if they like the same idol, they can make their relationship with their friends closer. Others include: making yourself curious about a star (28.0%); Being able to meet different people makes life more diverse (24.2%); On the contrary, I feel a little disgusted with the star chased by people around me (23.8%); The other party constantly persuaded themselves to join the "fan group" (21.0%); Also began to prepare to join the idolize team (20.8%); I learned a lot of "rice circle knowledge" and expanded my knowledge. In addition, 19.6% of the respondents said that it had no impact.

　　Chen Luxin believes that rational idolize is very important. "Some fans launched a war of abuse on the Internet without a word, which seems to be defending idols, which actually caused a worse impact."

　　How to be rational, idolize? 43.0% of the respondents suggested idolize within their own financial capacity, 46.1% felt that others should not be forced to like their idols, and 38.3% felt that others should be allowed to comment on idols. Others include: leaving enough private space and privacy for idols (39.0%); Do not act excessively when seeing idols (32.6%); Do not fight "war of words" on social networking sites (32.6%); Dig out the places worth learning from idols (30.5%); Insist on caring for relatives and friends around you (26.0%); Except idolize, they have their own lives and plans (29.2%) and their own careers and jobs that they really love (23.6%).

Original Cell Press CellPress cell science

life sciences

Life science

Fibroblasts are diverse interstitial cells, which create signal niches by producing complex extracellular matrix and biophysical and biochemical clues, and participate in tissue balance and diseases. Fibroblasts have diverse lineages and a wide range of uses, but our understanding of these cells, which fill a considerable part of the human body, is still not comprehensive. Next, let’s understand the mysterious and fascinating fibroblasts from four aspects and embark on a human journey across time and space.

Definition of fibroblast

The term "fibroblast" refers to the following kinds of cells: (1) cells that secrete many macromolecules with the same structure and signal as the extracellular space of tissues; (2) Adopting the phenotype of myofibroblasts that contract instantaneously when dealing with tissue injury; (3) signal niche cells as resident stem cells; (4) As the progenitor cells of specialized differentiated interstitial cells, they are sometimes called mesenchymal stem cells (Lemos and Duffield, 2018; Pittenger et al. , 1999, 2019）。

Fibroblasts create and maintain anatomically diverse connective tissue rich in extracellular matrix (ECM) to support a wide range of basic organ functions, such as resisting blunt and sharp skin injuries, stretching and elastic retraction in the organ range of lung, etc. In addition to producing connective tissue, fibroblasts serve as the progenitor cells of specialized interstitial cell types during embryonic development, adult homeostasis, injury, repair and remodeling, such as osteoblasts forming bones or fat cells filled with lipids.

The origin and development of fibroblasts

In 1858, German pathologist Rudolf Virchow first described fibroblasts as a unique cell type, which he called "Spindelzellen des Bindegewebes"-"Spindle cells of connective tissue" (Virchow, 1858；; Fig. 2A). Ernst Ziegler first put forward the term "fibroblast" to describe cells that produce new connective tissue after healing (Ziegler, 1895；; Fig. 2B), this observation was replicated by Santiago Ramón y Cajal, who observed that "célula fusiforme" or "fibro-células" are important producers of granulation tissue in skin wound healing and scar (Cajal, 1986；; Fig. 2C). The appearance of in vitro technology developed in the 1900 s promoted the research of fibroblasts. These methods allow primary fibroblasts from embryonic chicken heart explants to be cultured, and these cells can easily propagate before other cell types after passage (Burrows and Neymann, 1917; Carrel, 1912; Ebeling, 1913; Hogue, 1919； Fig. 2D). More than 50 years later, 3T3 fibroblast cell line from mouse embryo was established (Todaro and Green, 1963; Todaro and others,1964) further promoted our understanding of the biological and genealogical potential of fibroblasts. These findings include the identification of fibroblast growth factor (FGFS) (Gospodarovicz, 1974); Multi-line differentiation of cultured fibroblasts into bone, cartilage and fat cells (Junker et al., 2010); And the key role of fibroblasts in the production, remodeling and contraction of ECM.

Although there are a lot of studies on fibroblasts in vitro, the in vivo correlation of these cells is still unclear, and the real characteristics of fibroblasts and their pedigree potential in the in vivo primary environment have only recently been deeply explored. New evidence shows that fibroblasts have promoted major changes in the tumor-related environment, which has been widely reviewed elsewhere (Sahai et al., 2020).

Organ specificity of fibroblasts

The existence of tissue-specific fibroblast function and lineage can support the development, homeostasis and repair needs of specific organs. During embryonic development, multiple cell lines coalesce to form fibroblasts, which are filled with organs from all three somatic germ layers, such as skin and breast derived from ectoderm, skeletal muscle or myocardium derived from mesoderm, and lungs derived from endoderm. When fibroblasts proliferate in specific organs, they will produce unique microstructure, biophysical and biochemical components of connective tissue.

In organs rich in epithelial cells (for example, skin and lungs), fibroblasts in the skin produce a mechanically elastic, viscous and elastic structural foundation, which supports the epithelial cells of the outward layered epidermis and its many appendages, mainly hair follicles and sweat glands. Fibroblasts and other mesenchymal cell lines in the skin have established three anatomically different layers: papillary dermis, reticular dermis and dermal white adipose tissue (dWAT) (Figure 5A). Skin epithelial cells are derived from ectoderm, which has a unique level of connectivetissue. In contrast, lung epithelium originated from endoderm, forming a highly branched tree and eventually forming an inflatable sac called alveoli. The gas exchange function of lung depends on the close physical connection between alveolar epithelium and extensive capillary network, and on the repeated and rapid expansion and contraction ability of lung. These functions require the reticular ECM of the lung, which has the best viscoelasticity, but is strong enough to withstand the change of air pressure and prevent alveolar rupture and potentially fatal air pressure trauma. With the maturity of the lung, the lung mesenchymal progenitor cells assume different spatial positions and functions, including smooth muscle cells around bronchi and blood vessels, pericytes, numerous interstitial fibroblasts, adipocytes supporting lung cells and mesothelial cells of visceral pleura (Peng et al., 2013; Fig. 5B).

In interstitial organs (such as skeletal muscle and heart), unlike skin and lung, skeletal muscle has no epithelial structure, but is composed of large, highly differentiated and multinucleated muscle fibers arranged in parallel, and its main function is to generate strength through contraction. The connective tissue in muscle has a complex layered tissue. Its innermost layer is called endocardium, which surrounds a single muscle fiber and contains a special basement membrane rich in laminin and collagen IV. Laminin acts through its transmembrane receptor, helping the mechanical force to be transmitted from the intracellular contraction device to the inner muscle layer rich in collagen I and III (Chapman et al., 2016). Muscle fiber group is called bundle, surrounded by perimuscular layer, which forms a continuum with tendon, and is rich in so-called perimuscular layer "cable", that is, thick connective tissue bundle mainly composed of closely arranged type I and type III collagen III fibers. Finally, the whole muscle is wrapped by the connective tissue layer of the adventitia (Chapman et al., 2016). Myocardium is an anatomically and physiologically complex contractile organ. Its main cell group, cardiomyocytes, are connected with each other, and an electrically coupled tissue is formed through the sandwich disc that constitutes its middle layer, which is called myocardium. The heart is also rich in fibroblasts, which produce and reshape a powerful ECM network, which is very important for conductivity and heartbeat rhythm. In addition to myocardium, fibroblasts also exist in the outermost epicardium, which contains specialized adipose tissue, and the innermost endocardium, with a layer of endothelial cells at its edge.Unlike most other organs’ fibroblasts, which originated from mesenchymal progenitor cells through gradual standardization, most cardiac fibroblasts are formed through EMT, and fibroblasts located in interventricular septum and right ventricle are products of EndMT (Gittenberger-de Groot et al., 1998; Fig. 5D).

Application of fibroblasts in diseases

At present, the approved anti-fibrosis therapy is aimed at the activation of fibroblasts in established diseases and cannot restore the structure and function of diseased tissues. Therefore, developing strategies to promote the repair of damaged tissues will greatly promote the development of this field.

Although the plasticity of fibroblasts may be problematic in the context of fibrotic diseases, it also provides opportunities for regenerative intervention. Recently, this understanding has promoted the development of in-situ reprogramming into fibroblasts by molecular strategy to restore tissue anatomy and function (including direct reprogramming). In skin wounds, the innate ability of fibroblasts to support hair follicle regeneration can be induced by transcription reprogramming.

Examples have proved that the principle of therapeutic reprogramming of fibroblasts in vivo can be realized in liver and heart, such as transferring transcription factors such as Foxa3, Gata4, Hnf1a and Hnf4a to myofibroblasts in liver through viruses, reprogramming them into hepatocyte-like cells, and reducing the signs of liver fibrosis in mouse models (Rezvani et al., 2016; Song et al., 2016). The above examples clearly emphasize the therapeutic potential of reprogramming tissue-resident fibroblasts directly into "working" cells, and suggest it as a new scar replacement strategy. However, there are still several important problems to be solved, including the efficiency of reprogramming factor delivery using non-integrated vectors and high fibroblast specificity (if not exclusiveness), in order to transform this attractive method into safe clinical application.

Conclusion and prospect

In the past decades, our understanding of fibroblast biology under different organs and conditions has made remarkable progress. New methods and techniques have made this field develop from phenotypic study of cultured cells more than a century ago to complex genetic and functional observation in vivo. These advances reveal that fibroblasts from different organs (such as skin, lung, heart and skeletal muscle) have unexpected similarities and unique characteristics, so they are currently used to treat human diseases.

While great progress has been made, many problems and opportunities still exist. For example, the ongoing efforts to adopt single-cell omics and space genomics technologies will provide key insights into the heterogeneity of fibroblasts within and between tissues, and their ability to assume multiple functional States for physiological or disease triggers. With our understanding of the basic function of fibroblasts far beyond the scope of ECM synthesis, in-situ regulation of fibroblasts can bring new therapeutic possibilities for a wide range of diseases characterized by aging, pathological remodeling and tissue fibrosis. New research fields, including cross-regulation between wound fibroblasts, immune cells and peripheral nervous system, are very important for understanding how to restore tissues to their pre-injury state. Finally, effective clinical transformation will require rigorous verification in local human tissues and human-like models, such as organotypic cultures, xenotransplantation and organs derived from pluripotent cells. These advances will make it possible to prevent, treat and even reverse fibrosis through proper and controlled repair.

Related paper information

The original paper was published in Cell, a periodical of CellPress Cell Press. Click "Read the original" to view the paper.

▌ Paper title:

Fibroblasts: Origins, definitions, and functions in health and disease

▌ Website of the paper:

https://www.cell.com/cell/fulltext/S0092-8674(21)00792-3

▌DOI：

https://doi.org/10.1016/j.cell.2021.06.024

Read the original text

　　Cctv news: On June 14th, the State Council held a press conference on the operation of the national economy in May. Fu Linghui, spokesperson of the National Bureau of Statistics, introduced the operation of the national economy in May 2019 and answered questions from reporters. It is reported that this is also the first time that Director Fu has met with reporters.

　　Fu Linghui introduced at the meeting that in May, the national economy continued to operate in a reasonable range, continuing the overall stable, steady and progressive development trend.

　　First, the service industry continued to grow, and the emerging service industry developed in depth.

　　In May, the national service industry production index increased by 7.0% year-on-year, and the growth rate dropped by 0.4 percentage points from the previous month. From January to May, the national service industry production index increased by 7.3% year-on-year, 0.1 percentage point lower than that in January-April, and the same as that in January-February. In May, information transmission, software and information technology services, leasing and business services increased by 22.2% and 8.4% respectively year-on-year, and the growth rate was faster than the national service industry production index by 15.2 and 1.4 percentage points respectively. The business activity index of service industry was 53.5%, up 0.2 percentage points from last month, and remained above threshold. The business activity indexes of railway transportation, air transportation, postal service, accommodation, telecommunications, broadcasting, television and satellite transmission services, and Internet software and information technology services are all in the higher boom zone of more than 60.0%. The expected index of service business activities is 59.5%, which is at a high level.

　　Second, industrial production has increased steadily, and high-tech manufacturing has grown rapidly.

　　In May, the added value of industrial enterprises above designated size increased by 5.0% year-on-year, and the growth rate dropped by 0.4 percentage points from last month. From January to May, the added value of industrial enterprises above designated size increased by 6.0% year-on-year, and the growth rate dropped by 0.2 percentage points from January to April. In terms of economic types, in May, the added value of state-owned holding enterprises increased by 3.7% year-on-year, joint-stock enterprises increased by 6.6%, and foreign-invested enterprises from Hong Kong, Macao and Taiwan decreased by 0.3%. In terms of three categories, the added value of mining industry increased by 3.9% year-on-year, manufacturing industry increased by 5.0%, and electricity, heat, gas and water production and supply industries increased by 5.9%. The added value of high-tech manufacturing increased by 9.4% year-on-year, 4.4 percentage points faster than that of industries above designated size; The output of new energy vehicles and solar cells increased by 16.0% and 9.9% respectively. In May, the manufacturing purchasing managers index (PMI) sub-index, the production index and supplier delivery time index were 51.7% and 50.9%, respectively, both above the critical point.

　　Third, the growth rate of market sales accelerated, and the proportion of online retail continued to increase.

　　In May, the total retail sales of social consumer goods was 3,295.6 billion yuan, up 8.6% year-on-year, and the growth rate was 1.4 percentage points higher than that of last month. According to the location of business units, the retail sales of urban consumer goods was 2,830.4 billion yuan, an increase of 8.5% year-on-year; The retail sales of rural consumer goods reached 465.2 billion yuan, up by 9.0%. According to consumption types, catering revenue was 363.1 billion yuan, an increase of 9.4%; Retail sales of commodities reached 2,932.4 billion yuan, an increase of 8.5%. The retail sales of cosmetics, beverages, daily necessities, Chinese and western medicines above designated size increased by 16.7%, 12.7%, 11.4% and 11.2% respectively, which was 8.1, 4.1, 2.8 and 2.6 percentage points faster than the total retail sales of social consumer goods respectively.

　　From January to May, the total retail sales of social consumer goods reached 16,133.2 billion yuan, up 8.1% year-on-year, and the growth rate was 0.1 percentage point faster than that in January-April. The national online retail sales reached 3,864.1 billion yuan, up 17.8% year-on-year, and the growth rate was the same as that in January-April, 2.5 percentage points faster than that in January-March. Among them, the online retail sales of physical goods was 3,041.5 billion yuan, up 21.7%, accounting for 18.9% of the total retail sales of social consumer goods, up 0.3 and 0.7 percentage points respectively from January to April and January to March, and up 2.3 percentage points from the same period of last year.

　　4. Investment maintained growth, and investment in high-tech industries grew well.

　　From January to May, the national investment in fixed assets (excluding farmers) was 21,755.5 billion yuan, up 5.6% year-on-year, and the growth rate was 0.5 percentage points lower than that in January-April. Among them, private investment was 13,082.3 billion yuan, an increase of 5.3%. In terms of industries, investment in the primary industry decreased by 2.3% year-on-year; Investment in the secondary industry increased by 3.2%, of which investment in manufacturing industry increased by 2.7%, 0.2 percentage points faster than that in January-April; Investment in the tertiary industry increased by 7.1%, of which infrastructure investment increased by 4.0%. Investment in high-tech industries grew rapidly. Investment in high-tech manufacturing and high-tech service industries increased by 10.2% and 15.6% respectively year-on-year, and the growth rate was 4.6 and 10.0 percentage points faster than the total investment. From January to May, the national investment in real estate development was 4,607.5 billion yuan, up by 11.2% year-on-year. The growth rate dropped by 0.7 percentage points from January to April and accelerated by 1.7 percentage points over the previous year. The national commercial housing sales area was 555.18 million square meters, down 1.6% year-on-year; The national sales of commercial housing reached 5,177.3 billion yuan, up 6.1% year-on-year.

　　V. The employment situation is generally stable, and the survey unemployment rate is flat.

　　From January to May, 5.97 million new jobs were created in cities and towns nationwide, accounting for 54% of the annual plan. In May, the national urban survey unemployment rate was 5.0%, the same as last month. Among them, the survey unemployment rate of the population aged 25-59 was 4.5%, which was 0.2 percentage points lower than that of the previous month and dropped for three consecutive months. The survey unemployment rate in 31 big cities and towns was 5.0%, which was the same as last month. The average weekly working hours of employees in enterprises nationwide were 46.3 hours, an increase of 0.5 hours year-on-year.

　　Six, the consumer price rose moderately, and the price increase of industrial producers fell back.

　　In May, the national consumer price rose by 2.7% year-on-year, an increase of 0.2 percentage points over the previous month, which was the same as the previous month. By category, the prices of food, tobacco and alcohol rose by 5.8%, clothing by 1.7%, housing by 1.8%, daily necessities and services by 1.0%, transportation and communication by 0.9%, education, culture and entertainment by 2.6%, medical care by 2.5% and other goods and services by 2.1%. After deducting food and energy prices, the core CPI rose by 1.6%, down 0.1 percentage point from last month. From January to May, the national consumer price rose by 2.2% year-on-year.

　　In May, the ex-factory price of industrial producers nationwide rose by 0.6% year-on-year, down by 0.3 percentage points from the previous month and up by 0.2% from the previous month. The purchase price of industrial producers nationwide rose by 0.2% year-on-year, which was flat from the previous month. From January to May, the ex-factory price and the purchase price of national industrial producers rose by 0.4% and 0.2% respectively.

　　7. Exports maintained rapid growth and the trade structure was constantly optimized.

　　In May, the total import and export volume was 2,592.5 billion yuan, a year-on-year increase of 2.9%. Among them, exports were 1,435.8 billion yuan, an increase of 7.7%; Imports reached 1,156.7 billion yuan, down 2.5%. Import and export balance, trade surplus of 279.1 billion yuan, an increase of 89.8%. From January to May, the total import and export volume was 12,104.1 billion yuan, a year-on-year increase of 4.1%. Among them, exports were 6,498.7 billion yuan, an increase of 6.1%; Imports reached 5,605.3 billion yuan, up by 1.8%. The structure of trade mode was further optimized. From January to May, the import and export of general trade increased by 6.1% year-on-year, accounting for 59.9% of the total import and export, up by 1.1 percentage points over the same period of last year. The import and export of private enterprises increased by 11.1%, accounting for 41.4% of the total import and export, an increase of 2.6 percentage points over the same period of last year. From January to May, industrial enterprises above designated size achieved a export delivery value of 4,763.4 billion yuan, a year-on-year increase of 4.4%.

　　8. Deepening structural reform on the supply side and improving the efficiency of service enterprises.

　　At the end of April, the asset-liability ratio of industrial enterprises above designated size was 56.8%, down 0.5 percentage points year-on-year. Commercial housing inventory decreased. At the end of May, the area of commercial housing for sale in China was 509.28 million square meters, down 9.1% year-on-year, down 4.53 million square meters from the end of April. The unit cost of enterprises is lower than that at the beginning of the year. Investment in the short-board sector has increased. From January to May, the investment in ecological protection, environmental management and education increased by 41.5% and 15.4% respectively, which was 35.9 and 9.8 percentage points faster than the total investment.

　　From January to April, the operating income of service enterprises above designated size increased by 9.8% year-on-year, among which the strategic emerging service industry, science and technology service industry and high-tech service industry increased by 12.1%, 11.9% and 11.9% respectively, which were 2.3, 2.1 and 2.1 percentage points faster than all service industries above designated size. The operating profit of service enterprises above designated size increased by 9.2% year-on-year, and the growth rate was 0.8 percentage points higher than that of the same period of last year. From January to April, the operating income of industrial enterprises above designated size increased by 5.1% year-on-year, and the total profit decreased by 3.4% year-on-year. From January to April, the profit rate of operating income of industrial enterprises above designated size was 5.52%, 0.21 percentage points higher than that in January-March.

　　Fu Linghui said that, on the whole, the national economy in May was generally stable, steady and progressing, and continued to operate in a reasonable range. At present, the external environment is unstable and uncertain, the problem of insufficient domestic development imbalance is still outstanding, and the foundation of sustained and healthy economic development needs to be consolidated.

On August 1st, the movie "Catch the Doll", with the excellent performances of Shen Teng and Mary, successfully broke through 2.4 billion at the box office, which injected vitality into the recently slightly deserted movie market. The success of this film is largely due to the re-engagement of the golden combination of "Shen Ma+Yan Fei Peng Damo". In the process of constructing the universe of Xihong City, directors Yan Fei and Peng Damo have already proved their strength through goodbye mr. loser and The Richest Man in Xihong City. These works are all from their hands, and they have also won a win-win situation for Mahua FunAge in word of mouth and box office. Back in 2003, Beijing Free Element Film and Television Culture Communication Co., Ltd., the predecessor of Mahua FunAge, was founded by three young people with different backgrounds, including Yu Kai of Chinese Department of Peking University, You Liang Tian of Chinese Opera, and entrepreneur Zhang Chen. At first, they tried to adapt the novel into a TV series, but it failed because of the influence of SARS. Subsequently, You Liang Tian turned to the field of drama, and released his first work, I’ll give you a twist if you want to eat it. Although it was initially challenged by the box office, it finally found its own audience in Haidian Theater with its unique style and word-of-mouth fermentation, and Mahua FunAge became famous.

The addition of actors such as Shen Teng, Allen, Wei Xiang, Song Yang and Du Xiaoyu further enriched the cast of Mahua FunAge, and many of them joined through internal recommendation, forming a stable team foundation. Mary, in particular, attracted the attention of Peng Damo for her outstanding performance in the small theater, and eventually became an indispensable member of Mahua FunAge.

The turning point of Mahua FunAge appeared on the stage of the Spring Festival Evening. The skits written and directed by Yan Fei and Peng Damo, especially the role of "Hao Jian" played by Shen Teng, gradually made the team members familiar to the national audience. Despite the enormous pressure of the Spring Festival Gala, the Mahua FunAge team boarded the Spring Festival Gala for many years with unremitting efforts and unique creativity, which not only enhanced its popularity, but also promoted the development of its members’ personal careers, and Shen Teng became an important figure in China comedy movies.

In 2015, goodbye mr. loser, the first work of Mahua FunAge’s transitional film industry, was a great success, which not only verified the feasibility of adapting drama into film, but also opened a new chapter in Mahua FunAge’s film. Subsequent works, such as The Richest Man in Xihong City, faced with speculation about the change of creative team, but Yan Fei and Peng Damo still insisted on their own creative rhythm and style and continued to introduce popular works.

Looking at the development of Mahua FunAge, from the initial exploration to becoming the backbone of comedy, it is inseparable from the tacit cooperation of the core team and the continuous exploration of comedy art. Whether it’s a stage play or a movie, Mahua FunAge always maintains the pursuit of quality and respect for the audience, and continues to bring laughter to the audience.

Welcome to the Autohome Qingdao preferential promotion channel, revealing an exciting car buying opportunity for you! At present, high-profile models are giving back to consumers with great price discounts. In the bustling city of Qingdao, Blue Electric E5 is conducting an unprecedented promotion, with the highest discount reaching an astonishing 40,100 yuan. Surprisingly, the minimum starting price has been reduced to 99,800 yuan, providing car buyers with a very attractive car purchase option. If you are interested in this model, be sure to click the quotation form below to learn more about the preferential policies, and strive to lock in this rare preferential opportunity as soon as possible to realize your car purchase dream.

The exterior design of the blue electric car series E5 shows a simple and technological style. On the front face, it adopts a unique grille design with smooth lines, which not only highlights the sense of power but also the sense of refinement. The overall shape is stable, fusing futuristic and practical, making people recognize its unique identity at a glance.

The Blue Electric E5 shows its side-facing charm with elegant body proportions. The body size is 4760mm x 1865mm x 1710mm, and the wheelbase reaches 2785mm, ensuring the comfort of the interior space. The front and rear wheelbases are 1585mm and 1580mm respectively, providing a stable driving foundation. The tire specifications are quite balanced. The 225/55 R18 tires are selected, and the delicate wheel design is matched, which not only enhances the driving performance, but also adds to the visual movement of the vehicle.

The interior design of the Blue Electric E5 shows a simple yet luxurious style. The 12.3-inch central control screen stands in front of the driver, which is clear and easy to operate. It integrates multimedia, navigation, telephone, air conditioning and sunroof control to provide convenience for the driver. The steering wheel is made of exquisite leather material, which brings a comfortable grip and supports manual up and down adjustment to adapt to the needs of different drivers. The USB/Type-C interface in the car is reasonably distributed, and there is 1 in the front and rear rows, which is convenient for passengers to connect electronic devices. In terms of seats, imitation leather material is used to provide front and rear adjustment, backrest adjustment and high and low adjustment functions. The main and passenger seats are equipped with this comfortable configuration to ensure the comfort of long-distance driving. The second row of seats also supports backrest adjustment to increase the flexibility of the ride space, while the proportional reclining rear seats provide more practical space. Overall, the interior design of the Blue Electric E5 fully considers practicality and passenger experience.

The Blue Electric E5 is equipped with a 1.5L 110 horsepower L4 engine, which can reach a maximum power of 81 kilowatts, which can meet the daily driving needs. The matching E-CVT continuously variable transmission provides a smooth shifting experience and makes the driving process smoother. The combination of this engine and transmission provides the vehicle with enough power and good fuel economy.

Summarizing the views of Autohome owners, the exterior design of the Blue Electric E5 seems to have won its approval. It is described as atmospheric and smooth, and although it is not particularly stunning, it does not fall into the cliché. This modest SUV seems to be suitable for owners who seek practical and understated beauty. Such evaluations have allowed the Blue Electric E5 to find its place in the market and provide a reliable choice for wold-be users.

1905 movie network news On the evening of July 6, the film premiered in Beijing. The director, director, and other creators interacted with the audience through an online meeting. The heroine, Ah Sa, also appeared in the previous live broadcast.

The story of "Detective Wars" revolves around Liu Qingyun’s role as "Detective Crazy". In serial murders, preview murders and other incidents, he and the "Detective Couple" composed of Ah Sa and Lin Wei engage in fierce confrontations.

The plot of the film is ups and downs and confusing, and Liu Qingyun also exchanged notes of "I am a madman" and "I am a detective" to "confuse" the audience at the scene. When it comes to the shooting of "Detective War", he bluntly said that many scenes were very impressive, but the most memorable is the war at the end. He has been tearing this important scene before shooting, and it is very difficult to complete how to control the emotions and how to bring them in. It seems that the acting skills of "Crazy Guy" are also a great test for Liu Qingyun.

Ah Sa, who is on vacation, also helped out for the new film "Detective War" through live broadcast. Gillian, who is on vacation together, also appeared in surprise to play Call for the film. Joey Yung also actively confessed to her idol Liu Qingyun, revealing that she has been a fan of Wei Jiahui and Liu Qingyun since "The Big Times". "When I debuted, I also wrote that Liu Qingyun was my idol, Prince Charming."

On July 8, "Detective War" will be officially released. As a crime suspense film, director Wei Jiahui also hopes that everyone will not spoiler and walk into the theater to experience this exciting story together.