1.Complaints about contract and service disputes and consulting services with market operators can be made by calling the service hotline of China Securities Regulatory Commission.12386Guangdong CSI Investor Service and Dispute Mediation Center020-37853815, or to reflect the customer service channels of market operators.

2.Report the illegal acts of securities and futures in the jurisdiction, telephone number:020-37853900(Answer time:eight：30-11：thirty、13：30-17:00Except holidays and public holidays).

3.Online report: neris.csrc.gov.cn/jubaozhongxin/ (China securities regulatory commission securities futures illegal behavior report center).

4.Site Reception Location: Linjiang Avenue, Tianhe District, GuangzhouthreeNo.1 Development Center Guangdong Securities Regulatory Bureau Letters and Calls Reception Room (Visiting time: morningeight：30-11：thirtyIn the afternoonone：30-4:30, except holidays and public holidays); Mailing address: Linjiang Avenue, Tianhe District, GuangzhouthreeNo.1 development center15Building, postal code:510623.

　

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 (The above information was updated on August 25th, 2021)

　　BEIJING, Beijing, July 28 (Xinhua) Today, the 31st Summer Universiade in Chengdu will officially kick off. This is the third Universiade in Chinese mainland after 2001 and 2011, and the first comprehensive international sports event in western China.

　　As one of the largest and most prestigious sports feasts in the world, every Universiade will attract thousands of student athletes to participate in the competition. "Chengdu achieves dreams" is a sincere invitation from Chengdu to the world. From July 28th to August 8th, the Chengdu Universiade was full of wonderful performances.

　　The main stadium of Chengdu Universiade under the sunshine. Photo courtesy of Zhongjian Oriental Decoration 　

　　Aspect 1: The opening ceremony is simple and wonderful.

　　On the evening of 28th, the opening ceremony of Chengdu Universiade will be held in the main stadium of Donganhu Sports Park. It is reported that the opening ceremony follows the principle of "simplicity, safety and excitement". The scale of actors and volunteers is nearly 2,000, and the overall duration is less than 100 minutes, while the cultural performances are compressed to 15 minutes.

　　The theme of the opening ceremony also echoes the slogan of Chengdu Universiade, "Chengdu makes dreams come true". The 15-minute literary performance "Pursuing Dreams in Youth" consists of three paragraphs: Light of Youth, Vitality of Youth and Friendship of Youth, focusing on showing the good features of young people from the emotional and spiritual levels.

　　According to Chen Weiya, the general director, in order to present more wonderful things in a limited time, many creative ideas were also incorporated into the opening ceremony, making the necessary ceremony more memorable and artistic. The full use of high technology also enables more creativity to be realized in limited time and space, making the field full of artistic imagination and sense of space.

　　Aspect 2: Archery water polo takes the lead in starting the game.

　　On the day before the opening ceremony, archery and water polo took the lead. The China college archery team played in the recurve bow competition, which was the first appearance of the China delegation at the Chengdu Universiade.

　　Image source: official website, Chengdu Universiade

　　After a day of competition, in the men’s recurve bow team competition, China stopped in the quarter-elimination. The women’s team defeated Poland and India successively, and advanced to the women’s recurve bow team final.

　　The water polo competition is the first water event to start this Universiade. On the afternoon of 27th, the China men’s team played its first opponent, the Georgian team, in the water polo group match, and finally lost to the opponent at 7:13, which missed a good start.

　　Aspect 3: China athletes hit the first gold medal of the Universiade

　　The first gold medal of this Universiade will be produced in the martial arts event on the 29th. On the morning of 29th, the men’s Nanquan competition started first, and Sichuan athlete Cao Maoyuan played on behalf of the China team.

　　It is reported that Cao Maoyuan began to learn martial arts at the age of 5 and has been insisting on it for more than 20 years. Currently studying in Chengdu Institute of Physical Education, he has participated in many competitions and won national, provincial and municipal championships.

　　In order to prepare for the Universiade, Cao Maoyuan and his teammates conducted 28 days of closed training before the game. In an interview with the media before, he said that he hoped to get the gold medal at home.

　　The mascot of the Universiade "Rongbao" is hand-made. China News Service reporter Yang Kejia photo

　　Aspect 4: Rookie veterans gather in Chengdu

　　The Universiade has always been known as the "Little Olympics", and countless sports stars have started their legendary careers from here.

　　The China delegation of the Universiade consists of more than 700 people, among whom 411 athletes from more than 100 universities in 25 provinces (autonomous regions and municipalities) will compete in all 18 major events of the Universiade.

　　The average age of athletes is 22.9 years old. Among the 411 athletes, 387 participated in the Summer Universiade for the first time, 344 participated in the World Comprehensive Games for the first time on behalf of the country, and only 24 participated in the previous Universiade.

　　In other words, this Universiade, the China delegation will be led by newcomers. However, among the teenagers, there are also many familiar faces. For example, divers Zhang Jiaqi, swimmers Zhang Yufei and Qin Haiyang, and gymnasts Zou Jingyuan and Zhang Boheng will all appear on the stage of Chengdu Universiade.

　　Data Map: Zhang Yufei celebrated her victory after winning the World Championships. China News Service reporter Tang Yanjun photo

　　Tonight, the Chengdu Universiade will officially open, and the dreams of young athletes from all over the world will gather here. This summer, Chengdu achieved its dream.

On March 18th, the Information Office of the Autonomous Region Government held the forty-fourth press conference of COVID-19 Epidemic Prevention and Control Headquarters. Li Bingsheng, deputy director of the Public Security Department of the Autonomous Region, and Jiang Xiaofeng, deputy director of the Center for Comprehensive Disease Control and Prevention of the Autonomous Region, answered questions from reporters about the prevention and control of epidemic situation of overseas returnees.

Reporter: Please tell us what measures the autonomous region has taken to deal with the risk of overseas import. How many overseas personnel, Chinese overseas Chinese and international students have returned to Inner Mongolia? What is the daily traffic?

Li Bingsheng:At present, the situation of epidemic prevention and control in China continues to improve. There have been no new cases in our region and many provinces in China for several days, but the spread of overseas epidemic has accelerated. Recently, Chinese overseas students and migrant workers have a strong desire to return to China, and the risk of importing overseas epidemic has become the biggest risk at present. The situation is complex, the task is arduous and the pressure has suddenly increased.

I have a set of data here: according to the data of immigrants pushed by the National Immigration Bureau and the comparative analysis of civil aviation, airports, railways and other information, from 0: 00 on March 1 to 24: 00 on March 16, the data of people entering our region was 2,420, and from March 1 to 13, the average daily flow was about 110. From March 14th to 17th, the average flow was about 200 people. Through the action of "attacking and clearing No.4", the public security organs in the whole region have implemented verification and control measures for all the immigrants entering our region through big data+community arrangement and tracking one by one, and conducted centralized isolation medical observation and home isolation medical observation.

Judging from the above data, the risk of importing overseas epidemic is still very high. Therefore, in order to effectively prevent the spread of COVID-19 epidemic and effectively protect people’s health and life safety, according to the Law of People’s Republic of China (PRC) on the Prevention and Control of Infectious Diseases and the relevant requirements of the State Council’s joint prevention and control mechanism for COVID-19 epidemic, on March 15, the COVID-19 Epidemic Prevention and Control Command of Inner Mongolia issued the Announcement on Preventing the Import of Overseas Epidemic, which put forward requirements for the implementation of information declaration, centralized isolation and enhanced security for overseas personnel from Inner Mongolia, and strengthened the prevention of overseas epidemic.

In terms of specific social control, we will focus on the following aspects:

First, further strengthen the early warning of big data judgment and earnestly implement various closed-loop prevention and control measures for inbound transshipment.

First, we must predict the early warning in advance. The social control group has set up a special big data class to integrate and share the data information of border inspection, airports, railways, foreign affairs and other departments, and strive to predict every person who enters our region in advance and push it to Union City and Qixian County in time. All Union cities should also set up a special big data class to monitor daily, make further judgment and analysis, make the situation of every person who enters Mongolia more accurate, move forward to the prevention and control gate, report upwards, push in parallel and deploy downwards in a three-pronged manner. Make sure that there is no leakage and no dead angle.

The second is to carry out a major investigation of immigrants. In accordance with the requirements of the prevention and control headquarters of COVID-19, Inner Mongolia Autonomous Region, the object of centralized isolation shall cover all overseas returnees. At present, the big data special class is sorting out all the people who have entered Mongolia since March 1, and all the allied cities should immediately organize a comprehensive investigation of the returned overseas people within their jurisdiction, and all the returned overseas people within 14 days since March 1 should implement centralized isolation or home isolation measures as required. Public security organs at all levels should investigate and deal with those who deliberately conceal the history of living abroad and fail to report to the local authorities as required.

The third is to coordinate linkage and closed-loop prevention and control. The Public Security Department and the Health and Health Commission have sent competent leaders and special personnel to co-ordinate the transshipment and safety protection of airports in Beijing and the autonomous region. All localities and departments should strengthen coordination and linkage, keep a close eye on entry, transshipment, entry into the zone and other links, adhere to the integration of online and offline, integration within and outside the zone, secure the customs at all levels, hand-to-hand handover step by step, and ensure that the whole process is known and controllable.

Two, strictly implement the centralized isolation, home isolation prevention and control measures.

According to the requirements of the autonomous region, people who come to our region from countries with serious epidemics such as Japan, South Korea, Italy and Iran are all concentrated in medical observation; People from other countries, except those who have the conditions of single-person home isolation, will be centralized and isolated for medical observation. All persons entering Mongolia must truthfully declare and register their identity information, local address, contact telephone number, itinerary within 14 days, health status, entry purpose and other information. Among them, the most worrying thing is the link of home isolation and community prevention and control. We should vigorously promote the "big data+grid" community policing work, speed up the construction of community full-time and part-time grid workers and other group defense forces, deepen the construction of smart security communities and safe communities, firmly hold the forefront of community prevention and control, and all localities should maximize their strength into communities, compact their responsibilities and strictly implement relevant requirements.

For those who really need to be isolated at home, they must apply to the community and conduct on-the-spot verification procedures at the county headquarters to ensure that they have fixed housing, can meet the conditions of living alone, and meet the standards of medical isolation, before they can take 14-day medical observation measures of single-person home isolation. The territory should implement the one-to-one management and service guarantee measures of one person, one special class and one person, one program.

The social prevention and control group should grasp all the measures in all aspects in a down-to-earth manner, tightly and tightly, carefully and carefully, resolutely ensure that no one is allowed to enter Mongolia without being discovered before, and that no one is allowed to enter Mongolia without being isolated, and no case of imported cases from abroad will form an epidemic spread incident, resolutely build an overseas epidemic import defense line, and win the epidemic prevention and control people’s war, general war and blocking war in an all-round way.

Here, we hope that those who arrive in Inner Mongolia from abroad will strictly abide by the above regulations and actively cooperate with relevant departments to prevent and control the epidemic. At the same time, we also hope that the broad masses of the people will widely publicize and implement our social prevention and control measures.　

　　　　　　 Reporter: At present, there is a lot of information on the Internet about overseas returnees hiding their illness, disobeying quarantine management and affecting epidemic prevention and control. Has this happened in our region? What measures will the relevant departments take in response to such behavior? What shall we do if it is a foreign nationality?

Li Bingsheng:As this reporter said, in recent days, overseas returnees did conceal their illness, disobey isolation management, and affect epidemic prevention and control. On March 12th, Genghis Khan police station in Xincheng District of Hohhot found that Zhao and Shamou (sisters), residents of a residential area in Xincheng District of Hohhot, had close contact with Guo Moupeng, a confirmed patient of Zhengzhou’s new type of coronary pneumonia, during their flight entry from Turkey via Abu Dhabi on March 7th. Zhao and Shamou deliberately concealed their exit history after returning, and did not strictly implement the measures of "isolated observation" and "truthful declaration". During this period, they were free to move around the community for many times and went out to eat in restaurants, which caused the spread of COVID-19 epidemic. At present, the Public Security Bureau of Xincheng District of Hohhot has filed a case investigation against Zhao and Shamou on suspicion of obstructing the prevention and treatment of infectious diseases, and the disease control department has taken compulsory isolation observation measures against them.

In response to this kind of behavior, on March 16th, the Supreme Law, the Supreme People’s Procuratorate, the Ministry of Public Security, the Ministry of Justice and the General Administration of Customs jointly issued the Opinions on Further Strengthening Frontier Health and Quarantine Work and Punishing Illegal Crimes that Impede Frontier Health and Quarantine according to Law, sorting out six kinds of behaviors that may be convicted and imprisoned, including refusing to implement health and quarantine measures such as health declaration, body temperature monitoring, medical inspection and epidemiological investigation, concealing the epidemic situation by not filling in health declaration cards truthfully, and means of entry and exit transportation.

Some immigrants are lucky enough to take various measures to refuse to declare, or fail to truthfully declare their health status and cooperate with body temperature monitoring; There are also some immigrants who know that they have developed symptoms such as fever and dry cough, or have been to areas with serious epidemics, deliberately concealing the incidence and overseas travel history. Some people even took antipyretic drugs to lower their body temperature and cover up their fever symptoms, and got away with it in the customs health and quarantine. After entering the country, they were diagnosed as COVID-19, which led to people who were in close contact with them being infected or observed in isolation, posing great risks to public health and safety. According to the provisions of the Criminal Law and the newly issued Opinions, the above acts can be convicted and punished for "the crime of obstructing frontier health and quarantine" in accordance with the provisions of Article 332 of the Criminal Law.

At the same time, on March 15th, the COVID-19 Epidemic Prevention and Control Command of Inner Mongolia Autonomous Region issued the Announcement on Preventing the Import of Outbreaks from Abroad, which also made it clear that public security organs at all levels should investigate and deal with those who deliberately conceal the history of living abroad and fail to report to the local authorities as required. The circular also stressed that all immigrants should abide by the relevant regulations on the prevention and control of local epidemic situation during their stay in Inner Mongolia Autonomous Region, and those who refuse to cooperate with the prevention and control measures of epidemic situation will be investigated for legal responsibility according to law. All the immigrants mentioned here, including foreign nationals.

Reporter: Please tell us how to isolate and resettle overseas returnees.

Jiang Xiaofeng:In order to control the source of infection to the maximum extent, cut off the route of transmission, and effectively prevent the risk of imported COVID-19 epidemic from abroad, Inner Mongolia strictly implemented the relevant measures and regulations for epidemic prevention and control of overseas returnees during the epidemic period, comprehensively and meticulously grasped the basic information, entry time, passing ports, vehicles and physical health status of the inbound personnel, and implemented remote monitoring, entry screening, classified management, problem finding, timely disposal and scientific prevention and control.

　　　　　　　With regard to entry screening, people with fever and other symptoms and their close contacts found in entry wear disposable medical protective masks, conduct epidemiological investigation independently and collect samples for testing. After completing the entry frontier inspection procedures, the entry frontier inspection station will dock with the local epidemic prevention and control headquarters, and conduct investigation, diagnosis and treatment and close contact management as required. The rest of the staff carried out epidemiological investigation, sample collection, testing and entry-related procedures as required. All entry personnel should consciously abide by the relevant provisions of the state, autonomous regions and territories on epidemic prevention and control, and consciously accept inspection and quarantine, isolated observation and other prevention and control measures.

　

1905 movie network news The latest director’s work "Rowing Boy" continues to expand the cast. A few days ago, some media reported that they would join the film and play the role of Bowles, the coach of the rowing team. Although james wolk debuted for many years, it was the first time that he played the leading role in an important film.

　

The film is based on a true story. The central character of the story is Joel. During the Great Depression, he was attracted by the rowing coach of the University of Washington because of his excellent physical fitness, so he was able to study at the University of Washington. Joel and other players have been tortured by the coach for three years. In the end, they defeated the mighty German team on behalf of the United States and raised the Olympic champion trophy in front of Hitler. After the game, Joel and his teammates didn’t get rich just because they won the Olympic champion. The team members later became lawyers, doctors, engineers, etc., and were able to be independent by their own hands. They also get together every year and feel like brothers.

　

As for the actors, Callum Turner, Sam Strike and Luke Slatri will join the cast. At present, the film has no specific release information.

　　CCTV News:The Central Meteorological Observatory continued to issue a yellow rainstorm warning at 06: 00 on September 12. It is estimated that there will be heavy rainstorms in central and eastern Chongqing, northeastern Guizhou, southeastern Henan, southwestern and eastern Hubei, western Hunan, central Anhui, central Jiangsu, northwestern Jiangxi, northwestern and southern Yunnan, southwestern Guangxi, southwestern coast of Guangdong, and northern Hainan Island from 08: 00 on September 12 to 08: 00 on September 13. Among them, southeastern Chongqing, central Anhui, and northern Hainan Island. The maximum hourly rainfall in the above areas is 30 ~ 50 mm, and the local area can exceed 70 mm. There are also strong convective weather such as thunderstorms and strong winds.

　　Defense guide:

　　1, the government and relevant departments in accordance with their duties to do a good job of rainstorm prevention;

　　2. The traffic management department shall take traffic control measures in heavy rainfall sections according to the road conditions, and implement traffic guidance in waterlogged sections;

　　3, cut off the dangerous outdoor power supply in low-lying areas, suspend outdoor work in open places, and transfer people in dangerous areas and residents of dangerous houses to safe places to shelter from the rain;

　　4, check the city, farmland, fish pond drainage system, take the necessary drainage measures.

Original Cell Press CellPress cell science

life sciences

Life science

Fibroblasts are diverse interstitial cells, which create signal niches by producing complex extracellular matrix and biophysical and biochemical clues, and participate in tissue balance and diseases. Fibroblasts have diverse lineages and a wide range of uses, but our understanding of these cells, which fill a considerable part of the human body, is still not comprehensive. Next, let’s understand the mysterious and fascinating fibroblasts from four aspects and embark on a human journey across time and space.

Definition of fibroblast

The term "fibroblast" refers to the following kinds of cells: (1) cells that secrete many macromolecules with the same structure and signal as the extracellular space of tissues; (2) Adopting the phenotype of myofibroblasts that contract instantaneously when dealing with tissue injury; (3) signal niche cells as resident stem cells; (4) As the progenitor cells of specialized differentiated interstitial cells, they are sometimes called mesenchymal stem cells (Lemos and Duffield, 2018; Pittenger et al. , 1999, 2019）。

Fibroblasts create and maintain anatomically diverse connective tissue rich in extracellular matrix (ECM) to support a wide range of basic organ functions, such as resisting blunt and sharp skin injuries, stretching and elastic retraction in the organ range of lung, etc. In addition to producing connective tissue, fibroblasts serve as the progenitor cells of specialized interstitial cell types during embryonic development, adult homeostasis, injury, repair and remodeling, such as osteoblasts forming bones or fat cells filled with lipids.

The origin and development of fibroblasts

In 1858, German pathologist Rudolf Virchow first described fibroblasts as a unique cell type, which he called "Spindelzellen des Bindegewebes"-"Spindle cells of connective tissue" (Virchow, 1858；; Fig. 2A). Ernst Ziegler first put forward the term "fibroblast" to describe cells that produce new connective tissue after healing (Ziegler, 1895；; Fig. 2B), this observation was replicated by Santiago Ramón y Cajal, who observed that "célula fusiforme" or "fibro-células" are important producers of granulation tissue in skin wound healing and scar (Cajal, 1986；; Fig. 2C). The appearance of in vitro technology developed in the 1900 s promoted the research of fibroblasts. These methods allow primary fibroblasts from embryonic chicken heart explants to be cultured, and these cells can easily propagate before other cell types after passage (Burrows and Neymann, 1917; Carrel, 1912; Ebeling, 1913; Hogue, 1919； Fig. 2D). More than 50 years later, 3T3 fibroblast cell line from mouse embryo was established (Todaro and Green, 1963; Todaro and others,1964) further promoted our understanding of the biological and genealogical potential of fibroblasts. These findings include the identification of fibroblast growth factor (FGFS) (Gospodarovicz, 1974); Multi-line differentiation of cultured fibroblasts into bone, cartilage and fat cells (Junker et al., 2010); And the key role of fibroblasts in the production, remodeling and contraction of ECM.

Although there are a lot of studies on fibroblasts in vitro, the in vivo correlation of these cells is still unclear, and the real characteristics of fibroblasts and their pedigree potential in the in vivo primary environment have only recently been deeply explored. New evidence shows that fibroblasts have promoted major changes in the tumor-related environment, which has been widely reviewed elsewhere (Sahai et al., 2020).

Organ specificity of fibroblasts

The existence of tissue-specific fibroblast function and lineage can support the development, homeostasis and repair needs of specific organs. During embryonic development, multiple cell lines coalesce to form fibroblasts, which are filled with organs from all three somatic germ layers, such as skin and breast derived from ectoderm, skeletal muscle or myocardium derived from mesoderm, and lungs derived from endoderm. When fibroblasts proliferate in specific organs, they will produce unique microstructure, biophysical and biochemical components of connective tissue.

In organs rich in epithelial cells (for example, skin and lungs), fibroblasts in the skin produce a mechanically elastic, viscous and elastic structural foundation, which supports the epithelial cells of the outward layered epidermis and its many appendages, mainly hair follicles and sweat glands. Fibroblasts and other mesenchymal cell lines in the skin have established three anatomically different layers: papillary dermis, reticular dermis and dermal white adipose tissue (dWAT) (Figure 5A). Skin epithelial cells are derived from ectoderm, which has a unique level of connectivetissue. In contrast, lung epithelium originated from endoderm, forming a highly branched tree and eventually forming an inflatable sac called alveoli. The gas exchange function of lung depends on the close physical connection between alveolar epithelium and extensive capillary network, and on the repeated and rapid expansion and contraction ability of lung. These functions require the reticular ECM of the lung, which has the best viscoelasticity, but is strong enough to withstand the change of air pressure and prevent alveolar rupture and potentially fatal air pressure trauma. With the maturity of the lung, the lung mesenchymal progenitor cells assume different spatial positions and functions, including smooth muscle cells around bronchi and blood vessels, pericytes, numerous interstitial fibroblasts, adipocytes supporting lung cells and mesothelial cells of visceral pleura (Peng et al., 2013; Fig. 5B).

In interstitial organs (such as skeletal muscle and heart), unlike skin and lung, skeletal muscle has no epithelial structure, but is composed of large, highly differentiated and multinucleated muscle fibers arranged in parallel, and its main function is to generate strength through contraction. The connective tissue in muscle has a complex layered tissue. Its innermost layer is called endocardium, which surrounds a single muscle fiber and contains a special basement membrane rich in laminin and collagen IV. Laminin acts through its transmembrane receptor, helping the mechanical force to be transmitted from the intracellular contraction device to the inner muscle layer rich in collagen I and III (Chapman et al., 2016). Muscle fiber group is called bundle, surrounded by perimuscular layer, which forms a continuum with tendon, and is rich in so-called perimuscular layer "cable", that is, thick connective tissue bundle mainly composed of closely arranged type I and type III collagen III fibers. Finally, the whole muscle is wrapped by the connective tissue layer of the adventitia (Chapman et al., 2016). Myocardium is an anatomically and physiologically complex contractile organ. Its main cell group, cardiomyocytes, are connected with each other, and an electrically coupled tissue is formed through the sandwich disc that constitutes its middle layer, which is called myocardium. The heart is also rich in fibroblasts, which produce and reshape a powerful ECM network, which is very important for conductivity and heartbeat rhythm. In addition to myocardium, fibroblasts also exist in the outermost epicardium, which contains specialized adipose tissue, and the innermost endocardium, with a layer of endothelial cells at its edge.Unlike most other organs’ fibroblasts, which originated from mesenchymal progenitor cells through gradual standardization, most cardiac fibroblasts are formed through EMT, and fibroblasts located in interventricular septum and right ventricle are products of EndMT (Gittenberger-de Groot et al., 1998; Fig. 5D).

Application of fibroblasts in diseases

At present, the approved anti-fibrosis therapy is aimed at the activation of fibroblasts in established diseases and cannot restore the structure and function of diseased tissues. Therefore, developing strategies to promote the repair of damaged tissues will greatly promote the development of this field.

Although the plasticity of fibroblasts may be problematic in the context of fibrotic diseases, it also provides opportunities for regenerative intervention. Recently, this understanding has promoted the development of in-situ reprogramming into fibroblasts by molecular strategy to restore tissue anatomy and function (including direct reprogramming). In skin wounds, the innate ability of fibroblasts to support hair follicle regeneration can be induced by transcription reprogramming.

Examples have proved that the principle of therapeutic reprogramming of fibroblasts in vivo can be realized in liver and heart, such as transferring transcription factors such as Foxa3, Gata4, Hnf1a and Hnf4a to myofibroblasts in liver through viruses, reprogramming them into hepatocyte-like cells, and reducing the signs of liver fibrosis in mouse models (Rezvani et al., 2016; Song et al., 2016). The above examples clearly emphasize the therapeutic potential of reprogramming tissue-resident fibroblasts directly into "working" cells, and suggest it as a new scar replacement strategy. However, there are still several important problems to be solved, including the efficiency of reprogramming factor delivery using non-integrated vectors and high fibroblast specificity (if not exclusiveness), in order to transform this attractive method into safe clinical application.

Conclusion and prospect

In the past decades, our understanding of fibroblast biology under different organs and conditions has made remarkable progress. New methods and techniques have made this field develop from phenotypic study of cultured cells more than a century ago to complex genetic and functional observation in vivo. These advances reveal that fibroblasts from different organs (such as skin, lung, heart and skeletal muscle) have unexpected similarities and unique characteristics, so they are currently used to treat human diseases.

While great progress has been made, many problems and opportunities still exist. For example, the ongoing efforts to adopt single-cell omics and space genomics technologies will provide key insights into the heterogeneity of fibroblasts within and between tissues, and their ability to assume multiple functional States for physiological or disease triggers. With our understanding of the basic function of fibroblasts far beyond the scope of ECM synthesis, in-situ regulation of fibroblasts can bring new therapeutic possibilities for a wide range of diseases characterized by aging, pathological remodeling and tissue fibrosis. New research fields, including cross-regulation between wound fibroblasts, immune cells and peripheral nervous system, are very important for understanding how to restore tissues to their pre-injury state. Finally, effective clinical transformation will require rigorous verification in local human tissues and human-like models, such as organotypic cultures, xenotransplantation and organs derived from pluripotent cells. These advances will make it possible to prevent, treat and even reverse fibrosis through proper and controlled repair.

Related paper information

The original paper was published in Cell, a periodical of CellPress Cell Press. Click "Read the original" to view the paper.

▌ Paper title:

Fibroblasts: Origins, definitions, and functions in health and disease

▌ Website of the paper:

https://www.cell.com/cell/fulltext/S0092-8674(21)00792-3

▌DOI：

https://doi.org/10.1016/j.cell.2021.06.024

Read the original text

　　Beijing Education Examinations Institute issued the Notice of Beijing Municipality on Further Strengthening and Improving the Enrollment of Art Majors in Colleges and Universities yesterday. In 2024, Beijing will fully implement the unified professional examinations for six art majors, including music, dance, performance, broadcasting and hosting, art and design, and calligraphy.

　　According to Beijing Education Examinations Institute, the city adheres to education-oriented, classified guidance, fairness and justice, further promotes classified examinations for different majors, and improves the quality of talent selection. By 2024, it will establish an enrollment system for college art majors based on the unified college entrance examination, with the unified professional examinations in the city as the main body, based on the cultural achievements of the college entrance examination, professional examination results, with reference to students’ comprehensive quality evaluation, classified examinations, comprehensive evaluation and multiple admissions, which will basically form a fair, scientific talent selection and strong supervision.

　　Art majors in colleges and universities implement the evaluation method of "cultural quality+professional ability"

　　In terms of improving the professional examination methods, the city has vigorously promoted the classified examination of art majors. The enrollment of art majors in colleges and universities adopts the examination evaluation method of "cultural quality+professional ability". The cultural quality uses the examination results of the college entrance examination and the professional ability uses the examination results of the artistic professional ability. The art professional ability examination includes the city-wide unified examination and the college examination, and the classified examination is implemented according to the requirements of selecting and cultivating different art professionals. The city’s unified examination is organized by Beijing Education Examinations Institute, and the college examinations are organized by relevant universities.

　　At the same time, the city will improve the city-wide unified examination system for art majors. According to the requirements of the relevant documents of the Ministry of Education, we will study and formulate the unified examination methods for art majors in the city, and by 2024, we will fully implement the unified professional examinations for six art majors, including music, dance, performance, broadcasting and hosting, art and design, and calligraphy. Improve grading methods, strengthen grading management, and enhance the discrimination of examinations to meet the needs of talent selection in colleges and universities of different levels and types.

　　The number of on-site school exams does not exceed 6-mdash of the enrollment plan of related majors; 8 times

　　In addition, the "Notice" also clearly stipulates that the scope and scale of school examinations should be strictly controlled. For the art enrollment majors that have been covered by the unified examination in this city, in principle, colleges and universities enrolling students in Beijing should directly adopt the results of the unified examination. For a few art colleges with distinctive professional characteristics and high quality of personnel training, and high-level art majors with high requirements for candidates’ artistic talent, professional skills or basic skills, they can apply for organizing school examinations on the basis of the city’s unified examinations according to procedures. Colleges and universities in Beijing that organize school examinations should actively take online examinations or use the results of provincial unified examinations for primary elections, and strictly control the number of on-site school examinations. In principle, it should not exceed 6-mdash of the enrollment plan of relevant majors; Eight times.

　　The "Notice" also mentioned that it is necessary to improve and perfect the selection mechanism for appraisers. Expand the selection scope of appraisers, establish and improve the information database of appraisers in art majors, and promote the co-construction and sharing inside and outside Beijing. Optimize the composition of examiners, gradually increase the number of examiners, and expand the proportion of off-campus personnel outside Beijing to more than half. Explore the gradual establishment of a declaration system for the special relationship between examiners and candidates in art professional examinations. All examiners and candidates who are guided, guided or have relatives and other interests within the specified time shall declare as required, and strictly implement the avoidance system.

　　From 2024, high-level art troupes in colleges and universities will no longer be selected from the enrollment process of colleges and universities.

　　In improving the enrollment mechanism, it is clear that we should improve the enrollment methods. Art majors that use the results of the city’s unified examination as their professional examination results should be admitted to parallel volunteer on the basis that both the scores of the college entrance examination and the unified examination have reached the minimum control score line for the admission of art majors in this city, and the proportion of the scores of the college entrance examination and the city’s unified examination is not less than 50% in principle. The art majors that organize the school examination will be selected according to the candidates’ school examination results on the basis that the candidates’ scores in the college entrance examination and cultural courses reach the minimum control scores for the batch admission of ordinary majors in this city, the results of the city’s unified examination are qualified and meet the minimum performance requirements set by the school.

　　Since 2024, art majors such as art history, drama, film and television literature in colleges and universities have been selected according to the results of the cultural courses in the college entrance examination and the comprehensive quality evaluation of candidates. Except for the art majors that organize school examinations, all art majors should arrange provincial enrollment plans. Since 2024, high-level art troupes in colleges and universities will no longer be selected from the enrollment process of colleges and universities, but will be selected and trained by relevant colleges and universities from the students.

　　Gradually improve the admission scores of cultural courses in college entrance examination for art majors.

　　It is also clear in the Notice that the requirements for cultural achievements should be gradually raised. According to the requirements for the selection and training of talents of different art majors, the minimum control scores for the admission of cultural courses in the college entrance examination of art majors should be classified and gradually improved (the requirements for dance majors and performance majors can be appropriately lowered), and the tendency of "emphasizing majors over culture" in the selection of talents of art majors in some colleges and universities should be gradually reversed. Colleges and universities that organize school examinations can formulate exceptional admission methods for the scores of cultural courses in the college entrance examination in accordance with relevant regulations for a very small number of candidates who have excellent professional examination results or outstanding talents and performances in related professional fields.

　　The "Notice" emphasizes strengthening the standardized governance of art education and training institutions, and severely cracking down on illegal activities such as training institutions organizing or participating in cheating in exams and interfering with the enrollment order of exams.

　　Text/reporter Wu Wenjuan

　　SAIC’s brand-new entry-level model 350 will be officially rolled off the assembly line at Nanjing Pukou Factory on March 17th, and its price will be officially announced at the auto show that opened on April 23rd this year. After our repeated exposure, this model has gradually appeared clearly in front of us. Previously, two models with high and low configurations, 350D and 350C, have been exposed. Today, we are exposing a 350S model.

　　The appearance and interior of the S model are fully exposed. It can be seen from its streamlined configuration that this entry-level model will put more emphasis on practicality to ensure cost performance. From the configuration point of view, this is a low-profile model that has been exposed so far.

　　For example, the wheel hub is made of steel with plastic decorative cover, but the front bumper fog lamp as a safety configuration is not as stingy as some joint venture models. Of course, the comfortable configuration such as sunroof will not appear. In terms of interior, compared with the sporty black interior design of the 350D, the 350S adopts a two-color interior design with black upper part and beige lower part, separated by silver decorative strips.

　　Of course, comfort configurations such as DVD LCD screen, navigation, automatic constant temperature air conditioning and multi-function steering wheel on the 350D model have been replaced by lower configurations. The 350S model adopts CD audio to support MP3 and WMA formats, and can also synchronize the Aux-in external audio interface hidden under the storage compartment cover in front of the shift lever to connect to the portable player. The air conditioning control system is controlled by three manual knobs. Although the steering wheel lacks multi-function buttons, it also adopts three sports style designs with silver and black colors.

　　According to the previous official data, Roewe 350 will continue to build the concept of connected life, and apply the development achievements of 3G network and mobile communication technology to realize the network informatization of automobiles. From the dashboard of Roewe 350, we can see some clues. Although it is not as fancy as the 550 model, it only keeps the pointer-type engine tachometer, and other information is displayed digitally through a large-size driving computer screen. The console panel is also designed in silver, with a cigarette lighter and two exposed water cup holders on the back, but without the folding cover on the 350D model.

　　The circular air-conditioning outlets on both sides reflect the young and fashionable side of the 350 model, and the front door panel is also designed with a water cup holder to enhance its practicality. Compared with the leather seat of the previously exposed low-profile model 350C, the 350S adopts a light-colored fabric seat cover, and a storage grid is also designed on the inner side of the passenger seat backrest, which can be used to place practical driving items such as maps.

　　SAIC Roewe 350 includes two models, CSA7150MC and CSA7150AC, which represent a brand-new 15S4U four-cylinder naturally aspirated 1.5L VTi engine with a peak value of 78kW (106HP). It is equipped with a five-speed manual transmission and a four-speed automatic manual transmission.

　　From the current exposure of vehicle configurations, including 350S, 350C and 350D, it is expected that there will be 5-6 models depending on the shape of the gearbox configuration, and there may be quite attractive starting prices. Let’s continue to pay attention to more news. (Text/thousands of miles)

　　 related articles：

　　The Roewe 350 high and low models will be exposed at the same time.
　　http://www.autohome.com.cn/news/201002/95933.html

For the early adopters with a young mentality, what is the greatest experience that a car can bring? It is not the smart configuration full of gimmicks, or the colorful and fashionable appearance, but the ability to really control it and let it go off-road. ICAR 03, with its original super-strong chassis, is like a "small steel gun on the road", which brings outstanding road handling performance, fast straights and sharp corners, and outdoor off-road can also provide an extraordinary electric four-wheel drive refreshing experience. It can be said that it is full of surprises and full of players in all road conditions.

The chassis is more stable, detours do not float, and mountain roads do not sway.

A car is not for looking at. Only when you drive it can you really feel its texture. The stability of the chassis depends on the performance of the suspension. iCAR 03 adopts the only original super-strong chassis of the same class, adopts a 3,500-ton integrated die-casting tower top structure, and has an all-aluminum honeycomb structure girder, which has higher cavity strength than ordinary steel plates, and can effectively resist side impact, with both structural strength of non-loaded body and comfort of loaded body, giving consideration to light weight and energy consumption performance.

More accurate control, perfect combination of performance and comfort.

When it comes to control, many people think that this is the world of fuel vehicles. With the participation of Prodif’s Asia-Pacific top team, which has been focusing on vehicle power system development and vehicle handling performance development for more than 30 years, the track chassis adjustment experience in F1, WRC, Le Mans and Dakar Rally was applied to iCAR 03, giving iCAR 03 excellent track genes, achieving better handling performance and bringing a real track-level driving experience. In addition, the number of turns on the steering wheel is reduced from 3 to 2.6, which also creates a sharp sense of direction when iCAR 03 turns.

While improving the handling performance, iCAR 03 has also been optimized in terms of comfort. The chassis structure of H-arm multi-link and hydraulic bushing is adopted, and the H-arm is made of hollow cast aluminum, which reduces the weight by 30%, reduces the unsprung impact, is light and high-strength, and greatly improves the comfort of bumpy road sections. In addition, the control arm bushing adopts hydraulic bushing technology, which can reduce the road vibration by more than 30% under bumpy road conditions, and adopts oversized suspension cushion to isolate the vibration of the motor more efficiently.

Lightweight, bringing firm and sensitive driving pleasure.

For a pure electric SUV, the length of the same cruising range is directly related to the weight of the whole vehicle, while the lightweight technology of iCAR 03 achieves the perfect balance between cruising range and vehicle weight, and at the same time, it also brings more sensitive and lighter handling. It adopts an original all-aluminum multi-cavity cage body, a luxury car-class all-aluminum body, and naturally comes with a regenerative anti-corrosion layer, which will never rust during its life cycle, reducing the weight by more than 30% compared with the traditional steel body, but improving the stiffness by 30%; While achieving the perfect unity of firmness and lightness, it also brings a large thrust-to-weight ratio, a lighter start, a more direct dynamic response and a more handy control, which has become the ultimate pursuit of off-road control.

Excellent chassis support makes iCAR 03 have a solid sense of road, clear response and strong passability, while professional and super-strong chassis technology can make you easily deal with all kinds of complex roads, bring you full control confidence and security, and satisfy your all-weather passion. Since the pre-sale, it has been popular among early adopters with young mentality. If you also want to be a galloper, then the "bottom" iCAR 03 must be your best choice.

Recently, JK Auto officially released the new model JK 009 seven-seat aisle version, priced from 439,000 yuan to 469,000 yuan. This new luxury MPV retains its unique personality while further enhancing the practicality of home and business use, and bringing a new round of competitive pressure to the electric vehicle market.

The perfect combination of home and business

Extreme Krypton 009 has always been known for its luxury configuration and large space. The seven-seat aisle version launched this time further enhances its household attributes and becomes the representative of "super dad car". The new version adds an aisle design in the car to facilitate passengers to travel freely, especially for family travel. This design takes into account commercial needs and does not lose face in business receptions. At the same time, Extreme Krypton 009 has an ultra-long battery life of 800 kilometers, which is enough to handle long-distance business travel.

Externally, the changes in the new 009 are obvious. A new lidar has been added to the front of the car, marking the step towards a higher level of intelligent driving. To highlight the luxury positioning of this model, the chrome area of the front lip and side skirts has also been increased, making the overall visual effect more grand. With a delicate chrome grille and breathing lights lit when parking, this car can attract attention in any situation.

The interior is luxuriously upgraded with unique details

The 009 not only highlights luxury in appearance, but also its interior design continues the high standards of extreme krypton. The whole car uses a lot of Nappa leather and flip fur materials to create a sense of luxury. Especially the design of the ambient lights, the delicate light and shadow effects are perfectly integrated with the interior decoration, bringing a unique visual enjoyment to the driver and passengers.

However, some users have reported that the piano paint panel of the center console is prone to fingerprints, which may affect the convenience of daily use. However, overall, these small problems do not affect the overall performance of the 009 on the interior.

Driving texture and technological innovation

The driving quality of the Extreme Krypton 009 has been significantly improved. Its chassis is equipped with a dual-cavity air suspension system, which greatly enhances the smoothness and comfort of the ride. Whether it is a long-distance drive or a city road, the 009 can perform well, providing both a soft ride experience and strong road feel and handling performance in Sport mode.

As a pure electric vehicle, the 009 also upgraded the battery system and adopted the 800V platform, achieving an amazing charging speed from 10% to 80% in 11 minutes. For users who travel frequently for long distances, this is undoubtedly a breakthrough.

High-end configuration and intelligent experience

The 009’s car system has also been upgraded, equipped with dual 8295 chips to ensure the smooth operation of the large screens in the car. The central control screen adopts a narrow-frame OLED screen, and the image quality is clear and delicate, which further enhances the sense of technology in the car. The rear ceiling TV has also been upgraded to a 17-inch OLED screen, allowing passengers to enjoy a better entertainment experience during long-distance journeys.

It is worth mentioning that the seat design of the 009 is also impressive. The whole car is equipped with the Extreme Krypton Eames recliner, which not only provides zero-gravity comfort, but also fully supports the passengers’ legs and ankles. Whether it is a long drive or a short break, the thoughtful design of the seat can bring the ultimate comfort experience.

The release of Krypton 009 has once again refreshed the market standard of luxury MPVs. Whether it is the appearance, interior, or performance and technology, it shows the brand concept of Krypton pursuing the ultimate. This car not only performs well in domestic and commercial scenarios, but also achieves breakthroughs in charging efficiency and driving texture. As Krypton continues to expand the market, its global layout has also made 009 a new choice for users in various countries. In the luxury electric vehicle market, Krypton 009 is undoubtedly a force that cannot be ignored.